Gene description for LARP4B
Gene name La ribonucleoprotein domain family, member 4B
Gene symbol LARP4B
Other names/aliases KIAA0217
LARP5
Species Homo sapiens
 Database cross references - LARP4B
ExoCarta ExoCarta_23185
Vesiclepedia VP_23185
Entrez Gene 23185
HGNC 28987
UniProt Q92615  
 LARP4B identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LARP4B
Molecular Function
    RNA binding GO:0003723 HDA
    mRNA 3'-UTR binding GO:0003730 IBA
    mRNA 3'-UTR binding GO:0003730 IDA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of translation GO:0045727 IBA
    positive regulation of translation GO:0045727 IMP
    positive regulation of 3'-UTR-mediated mRNA stabilization GO:1905870 IMP
Subcellular Localization
    nucleolus GO:0005730 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytoplasmic stress granule GO:0010494 IBA
    cytoplasmic stress granule GO:0010494 IDA
    membrane GO:0016020 HDA
 Experiment description of studies that identified LARP4B in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
6
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
7
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LARP4B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 RALY 22913
Affinity Capture-MS Homo sapiens
3 CCL3  
Affinity Capture-MS Homo sapiens
4 RBMXL1  
Affinity Capture-MS Homo sapiens
5 HNRNPC 3183
Affinity Capture-MS Homo sapiens
6 RBPMS 11030
Two-hybrid Homo sapiens
7 ELAVL2 1993
Affinity Capture-MS Homo sapiens
8 Bbs5  
Two-hybrid Mus musculus
9 FASTK  
Affinity Capture-MS Homo sapiens
10 LARP1B 55132
Affinity Capture-MS Homo sapiens
11 RPL10 6134
Affinity Capture-MS Homo sapiens
12 KIF20A 10112
Affinity Capture-MS Homo sapiens
13 ZFR 51663
Affinity Capture-MS Homo sapiens
14 PUM2 23369
Affinity Capture-MS Homo sapiens
15 HNRNPCL1 343069
Affinity Capture-MS Homo sapiens
16 SRSF8 10929
Affinity Capture-MS Homo sapiens
17 CAPZB 832
Affinity Capture-MS Homo sapiens
18 RPS20 6224
Proximity Label-MS Homo sapiens
19 IGF2BP3 10643
Affinity Capture-MS Homo sapiens
20 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
21 PABPC4L 132430
Affinity Capture-MS Homo sapiens
22 COPS5 10987
Affinity Capture-MS Homo sapiens
23 NCOA5  
Affinity Capture-MS Homo sapiens
24 NPM1 4869
Affinity Capture-MS Homo sapiens
25 SRRM2 23524
Affinity Capture-MS Homo sapiens
26 FBL 2091
Proximity Label-MS Homo sapiens
27 GUSBP5  
Affinity Capture-MS Homo sapiens
28 TRO  
Affinity Capture-MS Homo sapiens
29 Cenpe  
Affinity Capture-MS Mus musculus
30 TRA2A 29896
Affinity Capture-MS Homo sapiens
31 ZCCHC3  
Affinity Capture-MS Homo sapiens
32 STAU2 27067
Affinity Capture-MS Homo sapiens
33 FAM136A 84908
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 UBE2Q1 55585
Affinity Capture-MS Homo sapiens
35 Nono 53610
Two-hybrid Mus musculus
36 Gspt1 14852
Affinity Capture-MS Mus musculus
37 SUGP2  
Affinity Capture-MS Homo sapiens
38 Eif3a 13669
Affinity Capture-MS Mus musculus
39 IL13RA2 3598
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 RBM42  
Affinity Capture-MS Homo sapiens
41 NPAS1  
Affinity Capture-MS Homo sapiens
42 RPS11 6205
Affinity Capture-MS Homo sapiens
43 PABPC4 8761
Affinity Capture-MS Homo sapiens
44 FAM120A 23196
Affinity Capture-MS Homo sapiens
45 RBM8A 9939
Affinity Capture-MS Homo sapiens
46 KIF14 9928
Affinity Capture-MS Homo sapiens
47 LIN28A  
Affinity Capture-MS Homo sapiens
48 ATXN2 6311
Affinity Capture-MS Homo sapiens
49 CPEB1  
Proximity Label-MS Homo sapiens
50 AURKA 6790
Affinity Capture-MS Homo sapiens
51 CLK2 1196
Affinity Capture-MS Homo sapiens
52 SRP9 6726
Affinity Capture-MS Homo sapiens
53 SCAF1  
Affinity Capture-MS Homo sapiens
54 FHL3 2275
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 DMRTB1  
Two-hybrid Homo sapiens
56 RB1CC1 9821
Affinity Capture-MS Homo sapiens
57 WHSC1 7468
Affinity Capture-MS Homo sapiens
58 C17orf85  
Affinity Capture-MS Homo sapiens
59 PNN 5411
Affinity Capture-MS Homo sapiens
60 Pabpc1 18458
Affinity Capture-MS Mus musculus
61 RPL5 6125
Affinity Capture-MS Homo sapiens
62 PABPC1 26986
Affinity Capture-MS Homo sapiens
63 MKRN2 23609
Affinity Capture-MS Homo sapiens
64 NTRK1 4914
Affinity Capture-MS Homo sapiens
65 RPS24 6229
Proximity Label-MS Homo sapiens
66 CHERP 10523
Affinity Capture-MS Homo sapiens
67 MOV10 4343
Affinity Capture-MS Homo sapiens
68 PLXDC2 84898
Affinity Capture-MS Homo sapiens
69 Hnrnpf 98758
Affinity Capture-MS Mus musculus
70 HECTD1 25831
Affinity Capture-MS Homo sapiens
71 U2SURP 23350
Affinity Capture-MS Homo sapiens
72 LARP1 23367
Affinity Capture-MS Homo sapiens
73 ZNF326 284695
Affinity Capture-MS Homo sapiens
74 BCLAF1 9774
Affinity Capture-MS Homo sapiens
75 PAIP2B  
Affinity Capture-MS Homo sapiens
76 RBBP6 5930
Affinity Capture-MS Homo sapiens
77 OGT 8473
Reconstituted Complex Homo sapiens
78 LARP4 113251
Affinity Capture-MS Homo sapiens
79 Gnb2l1 14694
Two-hybrid Mus musculus
80 CLK3  
Affinity Capture-MS Homo sapiens
81 XPO1 7514
Affinity Capture-MS Homo sapiens
82 RC3H2  
Affinity Capture-MS Homo sapiens
83 ECT2 1894
Affinity Capture-MS Homo sapiens
84 SIRT7  
Affinity Capture-MS Homo sapiens
85 IFI16 3428
Affinity Capture-MS Homo sapiens
86 SRSF1 6426
Affinity Capture-MS Homo sapiens
87 PHIP 55023
Affinity Capture-MS Homo sapiens
88 CUL3 8452
Affinity Capture-MS Homo sapiens
89 PUM1 9698
Affinity Capture-MS Homo sapiens
90 METTL21B  
Affinity Capture-MS Homo sapiens
91 ZC3H11A  
Affinity Capture-MS Homo sapiens
92 APOBEC3B 9582
Affinity Capture-MS Homo sapiens
93 STRAP 11171
Affinity Capture-MS Homo sapiens
94 YTHDC1  
Affinity Capture-MS Homo sapiens
95 ZNF777  
Affinity Capture-MS Homo sapiens
96 MAPRE3  
Proximity Label-MS Homo sapiens
97 RPA3 6119
Proximity Label-MS Homo sapiens
98 GLYR1 84656
Affinity Capture-MS Homo sapiens
99 C12orf74  
Affinity Capture-MS Homo sapiens
100 DKC1 1736
Affinity Capture-MS Homo sapiens
101 APOBEC3F 200316
Affinity Capture-MS Homo sapiens
102 MYC  
Affinity Capture-MS Homo sapiens
103 HECW2  
Affinity Capture-MS Homo sapiens
104 PABPC5 140886
Affinity Capture-MS Homo sapiens
105 C14orf80  
Affinity Capture-MS Homo sapiens
106 SRSF10 10772
Affinity Capture-MS Homo sapiens
107 ICE2  
Affinity Capture-MS Homo sapiens
108 Dynll1 56455
Two-hybrid Mus musculus
109 Rpl35 66489
Affinity Capture-MS Mus musculus
110 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
111 FHL2 2274
Affinity Capture-MS Homo sapiens
112 AKAP1 8165
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
113 RBMS2 5939
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 RPS16 6217
Affinity Capture-MS Homo sapiens
115 PAIP1 10605
Affinity Capture-MS Homo sapiens
116 YBX1 4904
Affinity Capture-MS Homo sapiens
117 ASB3 51130
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
119 DHX36 170506
Affinity Capture-MS Homo sapiens
120 RC3H1 149041
Affinity Capture-MS Homo sapiens
121 SIRT6  
Affinity Capture-MS Homo sapiens
122 PARP1 142
Proximity Label-MS Homo sapiens
123 MNDA 4332
Affinity Capture-MS Homo sapiens
124 ATXN1L  
Two-hybrid Homo sapiens
125 PPIG 9360
Affinity Capture-MS Homo sapiens
126 SRSF12  
Affinity Capture-MS Homo sapiens
127 CDK18 5129
Affinity Capture-MS Homo sapiens
128 MKRN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
130 G3BP2 9908
Affinity Capture-MS Homo sapiens
131 APOBEC3D  
Affinity Capture-MS Homo sapiens
132 RBFOX2 23543
Affinity Capture-MS Homo sapiens
133 LARP7 51574
Affinity Capture-MS Homo sapiens
134 MAGED1 9500
Two-hybrid Homo sapiens
135 CDV3 55573
Co-fractionation Homo sapiens
136 UPF1 5976
Affinity Capture-MS Homo sapiens
137 CIT 11113
Affinity Capture-MS Homo sapiens
138 SHARPIN  
Affinity Capture-MS Homo sapiens
139 SERBP1 26135
Proximity Label-MS Homo sapiens
140 GNB2L1 10399
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
141 PSPC1 55269
Affinity Capture-MS Homo sapiens
142 PRMT1 3276
Affinity Capture-MS Homo sapiens
143 STRBP 55342
Affinity Capture-MS Homo sapiens
144 IGF2BP2 10644
Affinity Capture-MS Homo sapiens
145 CASC3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LARP4B is involved
No pathways found





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