Gene description for ADARB1
Gene name adenosine deaminase, RNA-specific, B1
Gene symbol ADARB1
Other names/aliases ADAR2
DRABA2
DRADA2
RED1
Species Homo sapiens
 Database cross references - ADARB1
ExoCarta ExoCarta_104
Vesiclepedia VP_104
Entrez Gene 104
HGNC 226
MIM 601218
UniProt P78563  
 ADARB1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ADARB1
Molecular Function
    RNA binding GO:0003723 EXP
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IDA
    double-stranded RNA binding GO:0003725 IBA
    double-stranded RNA binding GO:0003725 IDA
    double-stranded RNA adenosine deaminase activity GO:0003726 IBA
    double-stranded RNA adenosine deaminase activity GO:0003726 IDA
    mRNA binding GO:0003729 TAS
    adenosine deaminase activity GO:0004000 IEA
    protein binding GO:0005515 IPI
    tRNA-specific adenosine deaminase activity GO:0008251 IBA
    identical protein binding GO:0042802 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    adenosine to inosine editing GO:0006382 IBA
    adenosine to inosine editing GO:0006382 IDA
    RNA processing GO:0006396 IBA
    RNA processing GO:0006396 IDA
    mRNA processing GO:0006397 IEA
    neuromuscular synaptic transmission GO:0007274 IEA
    negative regulation of cell population proliferation GO:0008285 IDA
    base conversion or substitution editing GO:0016553 IC
    base conversion or substitution editing GO:0016553 IDA
    facial nerve morphogenesis GO:0021610 IEA
    hypoglossal nerve morphogenesis GO:0021618 IEA
    spinal cord ventral commissure morphogenesis GO:0021965 IEA
    negative regulation of cell migration GO:0030336 IDA
    multicellular organism growth GO:0035264 IEA
    negative regulation of protein kinase activity by regulation of protein phosphorylation GO:0044387 IDA
    positive regulation of viral genome replication GO:0045070 IMP
    innate immune response GO:0045087 IEA
    neuromuscular process controlling posture GO:0050884 IEA
    defense response to virus GO:0051607 IEA
    regulation of cell cycle GO:0051726 IDA
    innervation GO:0060384 IEA
    muscle tissue morphogenesis GO:0060415 IEA
    motor behavior GO:0061744 IEA
    motor neuron apoptotic process GO:0097049 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IBA
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    synapse GO:0045202 IEA
 Experiment description of studies that identified ADARB1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ADARB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNL2 29889
Affinity Capture-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 RALY 22913
Affinity Capture-MS Homo sapiens
4 HNRNPC 3183
Affinity Capture-MS Homo sapiens
5 RPL26L1 51121
Affinity Capture-MS Homo sapiens
6 RSBN1L  
Affinity Capture-MS Homo sapiens
7 ZNF771  
Affinity Capture-MS Homo sapiens
8 ZBTB11  
Affinity Capture-MS Homo sapiens
9 AATF  
Affinity Capture-MS Homo sapiens
10 ZNF346  
Two-hybrid Homo sapiens
11 KIAA0020 9933
Affinity Capture-MS Homo sapiens
12 SRPK2 6733
Affinity Capture-MS Homo sapiens
13 RSL24D1  
Affinity Capture-MS Homo sapiens
14 GTPBP10  
Affinity Capture-MS Homo sapiens
15 RPL13A 23521
Affinity Capture-MS Homo sapiens
16 RPL37A 6168
Affinity Capture-MS Homo sapiens
17 SDAD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 ZBTB41  
Affinity Capture-MS Homo sapiens
19 NMNAT1  
Affinity Capture-MS Homo sapiens
20 GNL3 26354
Affinity Capture-MS Homo sapiens
21 RPL15 6138
Affinity Capture-MS Homo sapiens
22 ZFR 51663
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 RPL14 9045
Affinity Capture-MS Homo sapiens
24 BUD13  
Affinity Capture-MS Homo sapiens
25 RSBN1  
Affinity Capture-MS Homo sapiens
26 ZNF92  
Affinity Capture-MS Homo sapiens
27 CCDC124 115098
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
28 UTP3 57050
Affinity Capture-MS Homo sapiens
29 SRSF8 10929
Affinity Capture-MS Homo sapiens
30 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
31 WDR36 134430
Affinity Capture-MS Homo sapiens
32 LRPPRC 10128
Co-fractionation Homo sapiens
33 IMP3 55272
Affinity Capture-MS Homo sapiens
34 RPL10A 4736
Affinity Capture-MS Homo sapiens
35 RBM28 55131
Affinity Capture-MS Homo sapiens
36 LLPH  
Affinity Capture-MS Homo sapiens
37 DDX24 57062
Affinity Capture-MS Homo sapiens
38 STOX1  
Two-hybrid Homo sapiens
39 USP39 10713
Co-fractionation Homo sapiens
40 CENPV 201161
Affinity Capture-MS Homo sapiens
41 CCDC137  
Affinity Capture-MS Homo sapiens
42 RRP12 23223
Affinity Capture-MS Homo sapiens
43 MPHOSPH10 10199
Affinity Capture-MS Homo sapiens
44 MRPS5 64969
Affinity Capture-MS Homo sapiens
45 CDK12 51755
Affinity Capture-MS Homo sapiens
46 BBX 56987
Affinity Capture-MS Homo sapiens
47 SPATS2L 26010
Affinity Capture-MS Homo sapiens
48 SURF6  
Affinity Capture-MS Homo sapiens
49 ADARB1 104
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
50 TTF1  
Affinity Capture-MS Homo sapiens
51 STAU2 27067
Affinity Capture-MS Homo sapiens
52 PRKRA 8575
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
53 DDX51  
Affinity Capture-MS Homo sapiens
54 FYTTD1  
Affinity Capture-MS Homo sapiens
55 RPL29 6159
Affinity Capture-MS Homo sapiens
56 RRP8  
Affinity Capture-MS Homo sapiens
57 ZNF768 79724
Affinity Capture-MS Homo sapiens
58 NOC3L 64318
Affinity Capture-MS Homo sapiens
59 RPS3A 6189
Affinity Capture-MS Homo sapiens
60 GLTSCR2  
Affinity Capture-MS Homo sapiens
61 MYCN  
Affinity Capture-MS Homo sapiens
62 CHD3 1107
Affinity Capture-MS Homo sapiens
63 DAP3 7818
Affinity Capture-MS Homo sapiens
64 RBFOX2 23543
Two-hybrid Homo sapiens
65 RPL19 6143
Affinity Capture-MS Homo sapiens
66 CTCF  
Affinity Capture-MS Homo sapiens
67 RBM19 9904
Affinity Capture-MS Homo sapiens
68 CCDC86  
Affinity Capture-MS Homo sapiens
69 ZCRB1  
Affinity Capture-MS Homo sapiens
70 BRIX1 55299
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
71 RPL27 6155
Affinity Capture-MS Homo sapiens
72 DDX31  
Affinity Capture-MS Homo sapiens
73 RPL30 6156
Affinity Capture-MS Homo sapiens
74 SCAF1  
Affinity Capture-MS Homo sapiens
75 DDX21 9188
Affinity Capture-MS Homo sapiens
76 RPL4 6124
Affinity Capture-MS Homo sapiens
77 WHSC1 7468
Affinity Capture-MS Homo sapiens
78 TARBP2  
Two-hybrid Homo sapiens
79 RPS10 6204
Affinity Capture-MS Homo sapiens
80 HIST1H2AG 8969
Affinity Capture-MS Homo sapiens
81 RPF2 84154
Affinity Capture-MS Homo sapiens
82 STAU1 6780
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
83 RPL5 6125
Affinity Capture-MS Homo sapiens
84 NOP2 4839
Affinity Capture-MS Homo sapiens
85 ZNF22  
Affinity Capture-MS Homo sapiens
86 UBE2I 7329
Two-hybrid Homo sapiens
87 RPL18A 6142
Affinity Capture-MS Homo sapiens
88 ZCCHC17  
Affinity Capture-MS Homo sapiens
89 DDX10  
Affinity Capture-MS Homo sapiens
90 NKRF 55922
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
91 RPL31 6160
Affinity Capture-MS Homo sapiens
92 RSL1D1 26156
Affinity Capture-MS Homo sapiens
93 NOC4L 79050
Affinity Capture-MS Homo sapiens
94 ZNF354A  
Affinity Capture-MS Homo sapiens
95 REXO4  
Affinity Capture-MS Homo sapiens
96 BEND7 222389
Affinity Capture-MS Homo sapiens
97 MOV10 4343
Affinity Capture-MS Homo sapiens
98 DDX54 79039
Affinity Capture-MS Homo sapiens
99 RPLP1 6176
Affinity Capture-MS Homo sapiens
100 LYAR 55646
Affinity Capture-MS Homo sapiens
101 RPS6 6194
Affinity Capture-MS Homo sapiens
102 ZNF483  
Affinity Capture-MS Homo sapiens
103 RPLP0 6175
Affinity Capture-MS Homo sapiens
104 RRP1B 23076
Affinity Capture-MS Homo sapiens
105 NKTR  
Affinity Capture-MS Homo sapiens
106 SPTY2D1  
Affinity Capture-MS Homo sapiens
107 DNTTIP2  
Affinity Capture-MS Homo sapiens
108 GTPBP4 23560
Affinity Capture-MS Homo sapiens
109 SRPK1 6732
Affinity Capture-MS Homo sapiens
110 C7orf50 84310
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 RPL11 6135
Affinity Capture-MS Homo sapiens
112 WDR46  
Affinity Capture-MS Homo sapiens
113 CENPN  
Affinity Capture-MS Homo sapiens
114 PPAN-P2RY11  
Affinity Capture-MS Homo sapiens
115 RPL32 6161
Affinity Capture-MS Homo sapiens
116 BMS1  
Affinity Capture-MS Homo sapiens
117 PRPF4B 8899
Affinity Capture-MS Homo sapiens
118 RPLP2 6181
Affinity Capture-MS Homo sapiens
119 C11orf57  
Affinity Capture-MS Homo sapiens
120 RPL7A 6130
Affinity Capture-MS Homo sapiens
121 MRTO4 51154
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 PNPT1 87178
Two-hybrid Homo sapiens
123 POP1 10940
Affinity Capture-MS Homo sapiens
124 ZBTB24  
Affinity Capture-MS Homo sapiens
125 GLE1 2733
Affinity Capture-MS Homo sapiens
126 SRSF1 6426
Affinity Capture-MS Homo sapiens
127 SRSF5 6430
Affinity Capture-MS Homo sapiens
128 TAF1B  
Affinity Capture-MS Homo sapiens
129 ZNF624 57547
Affinity Capture-MS Homo sapiens
130 RPS8 6202
Affinity Capture-MS Homo sapiens
131 RPL21 6144
Affinity Capture-MS Homo sapiens
132 RPL3 6122
Affinity Capture-MS Homo sapiens
133 EBNA1BP2 10969
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 PAPD5 64282
Affinity Capture-MS Homo sapiens
135 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
136 DHX30 22907
Affinity Capture-MS Homo sapiens
137 RPL7L1 285855
Affinity Capture-MS Homo sapiens
138 RPL7 6129
Affinity Capture-MS Homo sapiens
139 NIP7 51388
Affinity Capture-MS Homo sapiens
140 ZSCAN25  
Affinity Capture-MS Homo sapiens
141 ZNF512  
Affinity Capture-MS Homo sapiens
142 PRR3  
Affinity Capture-MS Homo sapiens
143 DKC1 1736
Affinity Capture-MS Homo sapiens
144 IFRD2 7866
Affinity Capture-MS Homo sapiens
145 CEBPZ  
Affinity Capture-MS Homo sapiens
146 ZCCHC6 79670
Affinity Capture-MS Homo sapiens
147 NOL12 79159
Affinity Capture-MS Homo sapiens
148 RPL35A 6165
Affinity Capture-MS Homo sapiens
149 RPL12 6136
Affinity Capture-MS Homo sapiens
150 GZF1  
Affinity Capture-MS Homo sapiens
151 HP1BP3 50809
Affinity Capture-MS Homo sapiens
152 HIST1H1A 3024
Affinity Capture-MS Homo sapiens
153 MYBBP1A 10514
Affinity Capture-MS Homo sapiens
154 RPL18 6141
Affinity Capture-MS Homo sapiens
155 BMI1  
Affinity Capture-MS Homo sapiens
156 ZC3HAV1 56829
Affinity Capture-MS Homo sapiens
157 Rpl35 66489
Affinity Capture-MS Mus musculus
158 NOP16 51491
Affinity Capture-MS Homo sapiens
159 TCEANC  
Two-hybrid Homo sapiens
160 ZFP62  
Affinity Capture-MS Homo sapiens
161 PDCD11 22984
Affinity Capture-MS Homo sapiens
162 RPL26 6154
Affinity Capture-MS Homo sapiens
163 FTSJ3 117246
Affinity Capture-MS Homo sapiens
164 PPP2CB 5516
Affinity Capture-MS Homo sapiens
165 TAF1A  
Affinity Capture-MS Homo sapiens
166 NGDN  
Affinity Capture-MS Homo sapiens
167 H2AFX 3014
Affinity Capture-MS Homo sapiens
168 RPL13 6137
Affinity Capture-MS Homo sapiens
169 YTHDC2 64848
Affinity Capture-MS Homo sapiens
170 DDX50 79009
Affinity Capture-MS Homo sapiens
171 ZNF354B  
Affinity Capture-MS Homo sapiens
172 C8orf33 65265
Affinity Capture-MS Homo sapiens
173 ZNF689  
Affinity Capture-MS Homo sapiens
174 ILF3 3609
Affinity Capture-MS Homo sapiens
175 RPL6 6128
Affinity Capture-MS Homo sapiens
176 RRS1 23212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
177 NLE1 54475
Affinity Capture-MS Homo sapiens
178 NOL10  
Affinity Capture-MS Homo sapiens
179 PIN1 5300
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
180 EHHADH 1962
Two-hybrid Homo sapiens
181 ZNF777  
Affinity Capture-MS Homo sapiens
182 ZNF48  
Affinity Capture-MS Homo sapiens
183 URB1 9875
Affinity Capture-MS Homo sapiens
184 C1orf35  
Affinity Capture-MS Homo sapiens
185 CCDC106  
Affinity Capture-MS Homo sapiens
186 NSA2  
Affinity Capture-MS Homo sapiens
187 TAF1D  
Affinity Capture-MS Homo sapiens
188 CENPU  
Affinity Capture-MS Homo sapiens
189 RPF1  
Affinity Capture-MS Homo sapiens
190 NIFK 84365
Affinity Capture-MS Homo sapiens
191 RPS26 6231
Affinity Capture-MS Homo sapiens
192 DDX27 55661
Affinity Capture-MS Homo sapiens
193 WWP2 11060
Affinity Capture-Western Homo sapiens
194 NOC2L 26155
Affinity Capture-MS Homo sapiens
195 NCL 4691
Affinity Capture-MS Homo sapiens
196 RPL27A 6157
Affinity Capture-MS Homo sapiens
197 YBX3 8531
Affinity Capture-MS Homo sapiens
198 UPF1 5976
Affinity Capture-MS Homo sapiens
199 TCF20  
Affinity Capture-MS Homo sapiens
200 ZNF770 54989
Affinity Capture-MS Homo sapiens
201 ZNF800  
Affinity Capture-MS Homo sapiens
202 TAF1C  
Affinity Capture-MS Homo sapiens
203 GRSF1 2926
Affinity Capture-MS Homo sapiens
204 GLYR1 84656
Affinity Capture-MS Homo sapiens
205 ZNF629 23361
Affinity Capture-MS Homo sapiens
206 Ilf3 16201
Two-hybrid Mus musculus
207 Ufl1  
Affinity Capture-MS Mus musculus
208 ADGRE5 976
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
209 ZNF845  
Affinity Capture-MS Homo sapiens
210 RPL36AL 6166
Affinity Capture-MS Homo sapiens
211 RBM34  
Affinity Capture-MS Homo sapiens
212 PURA 5813
Affinity Capture-MS Homo sapiens
213 ZMAT4  
Two-hybrid Homo sapiens
214 STRBP 55342
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
215 NVL  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
216 DDX56  
Affinity Capture-MS Homo sapiens
217 MRPS9 64965
Affinity Capture-MS Homo sapiens
218 RPL17 6139
Affinity Capture-MS Homo sapiens
219 IMP4  
Affinity Capture-MS Homo sapiens
220 RPS13 6207
Affinity Capture-MS Homo sapiens
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