Gene description for MNDA
Gene name myeloid cell nuclear differentiation antigen
Gene symbol MNDA
Other names/aliases PYHIN3
Species Homo sapiens
 Database cross references - MNDA
ExoCarta ExoCarta_4332
Vesiclepedia VP_4332
Entrez Gene 4332
HGNC 7183
MIM 159553
UniProt P41218  
 MNDA identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Thymus 23844026    
Urine 19056867    
 Gene ontology annotations for MNDA
Molecular Function
    double-stranded DNA binding GO:0003690 IBA
    protein binding GO:0005515 IPI
Biological Process
    activation of innate immune response GO:0002218 IBA
    cellular defense response GO:0006968 TAS
    DNA damage response GO:0006974 IMP
    negative regulation of B cell proliferation GO:0030889 IMP
    cellular response to interferon-beta GO:0035458 IBA
    positive regulation of apoptotic process GO:0043065 IMP
    B cell receptor signaling pathway GO:0050853 IMP
Subcellular Localization
    extracellular region GO:0005576 TAS
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IBA
    nucleolus GO:0005730 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    azurophil granule lumen GO:0035578 TAS
    intracellular membrane-bounded organelle GO:0043231 IDA
    extracellular exosome GO:0070062 HDA
    ficolin-1-rich granule lumen GO:1904813 TAS
 Experiment description of studies that identified MNDA in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for MNDA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNL2 29889
Affinity Capture-MS Homo sapiens
2 EIF3A 8661
Affinity Capture-MS Homo sapiens
3 ACTR2 10097
Affinity Capture-MS Homo sapiens
4 UTP18  
Affinity Capture-MS Homo sapiens
5 IGF2BP1 10642
Affinity Capture-MS Homo sapiens
6 EXOSC7 23016
Affinity Capture-MS Homo sapiens
7 TRMT1L 81627
Affinity Capture-MS Homo sapiens
8 PPP1CB 5500
Affinity Capture-MS Homo sapiens
9 KNOP1 400506
Affinity Capture-MS Homo sapiens
10 NOP58 51602
Affinity Capture-MS Homo sapiens
11 AATF  
Affinity Capture-MS Homo sapiens
12 KIAA0020 9933
Affinity Capture-MS Homo sapiens
13 ATXN2L 11273
Affinity Capture-MS Homo sapiens
14 MRTO4 51154
Affinity Capture-MS Homo sapiens
15 HIST1H1D 3007
Cross-Linking-MS (XL-MS) Homo sapiens
16 NOP56 10528
Affinity Capture-MS Homo sapiens
17 PRMT6  
Two-hybrid Homo sapiens
18 BYSL 705
Affinity Capture-MS Homo sapiens
19 URB2  
Affinity Capture-MS Homo sapiens
20 DHX57 90957
Affinity Capture-MS Homo sapiens
21 COPA 1314
Affinity Capture-MS Homo sapiens
22 WDR36 134430
Affinity Capture-MS Homo sapiens
23 PPP1CC 5501
Affinity Capture-MS Homo sapiens
24 NOL8  
Affinity Capture-MS Homo sapiens
25 LARP4B 23185
Affinity Capture-MS Homo sapiens
26 GPATCH4 54865
Affinity Capture-MS Homo sapiens
27 IGF2BP3 10643
Affinity Capture-MS Homo sapiens
28 NKRF 55922
Affinity Capture-MS Homo sapiens
29 DHX33  
Affinity Capture-MS Homo sapiens
30 TBL3 10607
Affinity Capture-MS Homo sapiens
31 EXOSC2 23404
Affinity Capture-MS Homo sapiens
32 LLPH  
Affinity Capture-MS Homo sapiens
33 DDX24 57062
Affinity Capture-MS Homo sapiens
34 H1FX 8971
Affinity Capture-MS Homo sapiens
35 CCDC137  
Affinity Capture-MS Homo sapiens
36 RRP12 23223
Affinity Capture-MS Homo sapiens
37 EGFL8  
Affinity Capture-MS Homo sapiens
38 FBL 2091
Affinity Capture-MS Homo sapiens
39 KRI1  
Affinity Capture-MS Homo sapiens
40 RPF2 84154
Affinity Capture-MS Homo sapiens
41 ZCCHC3  
Affinity Capture-MS Homo sapiens
42 PAK1IP1  
Affinity Capture-MS Homo sapiens
43 DDX51  
Affinity Capture-MS Homo sapiens
44 GRWD1 83743
Affinity Capture-MS Homo sapiens
45 TCEB3B  
Affinity Capture-MS Homo sapiens
46 DDX18 8886
Affinity Capture-MS Homo sapiens
47 RRP8  
Affinity Capture-MS Homo sapiens
48 DDX6 1656
Affinity Capture-MS Homo sapiens
49 WDR12 55759
Affinity Capture-MS Homo sapiens
50 EXOSC6 118460
Affinity Capture-MS Homo sapiens
51 NHP2 55651
Affinity Capture-MS Homo sapiens
52 MAK16  
Affinity Capture-MS Homo sapiens
53 PABPC4 8761
Affinity Capture-MS Homo sapiens
54 FAM120A 23196
Affinity Capture-MS Homo sapiens
55 CTCF  
Affinity Capture-MS Homo sapiens
56 RBM19 9904
Affinity Capture-MS Homo sapiens
57 GAR1 54433
Affinity Capture-MS Homo sapiens
58 PES1 23481
Affinity Capture-MS Homo sapiens
59 ATXN2 6311
Affinity Capture-MS Homo sapiens
60 BRIX1 55299
Affinity Capture-MS Homo sapiens
61 DDX31  
Affinity Capture-MS Homo sapiens
62 GNG8  
Affinity Capture-MS Homo sapiens
63 UTP14A 10813
Affinity Capture-MS Homo sapiens
64 DDX21 9188
Affinity Capture-MS Homo sapiens
65 RBM28 55131
Affinity Capture-MS Homo sapiens
66 CENPV 201161
Affinity Capture-MS Homo sapiens
67 STAU1 6780
Affinity Capture-MS Homo sapiens
68 NOL11  
Affinity Capture-MS Homo sapiens
69 NOP2 4839
Affinity Capture-MS Homo sapiens
70 STAU2 27067
Affinity Capture-MS Homo sapiens
71 PABPC1 26986
Affinity Capture-MS Homo sapiens
72 DDX10  
Affinity Capture-MS Homo sapiens
73 SARAF  
Affinity Capture-MS Homo sapiens
74 LAS1L 81887
Affinity Capture-MS Homo sapiens
75 HIST1H1E 3008
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
76 REXO4  
Affinity Capture-MS Homo sapiens
77 WDR75  
Affinity Capture-MS Homo sapiens
78 HIST1H1C 3006
Cross-Linking-MS (XL-MS) Homo sapiens
79 DDX54 79039
Affinity Capture-MS Homo sapiens
80 LYAR 55646
Affinity Capture-MS Homo sapiens
81 WHSC1L1  
Two-hybrid Homo sapiens
82 RRP1B 23076
Affinity Capture-MS Homo sapiens
83 PELP1 27043
Affinity Capture-MS Homo sapiens
84 MYBBP1A 10514
Affinity Capture-MS Homo sapiens
85 DDX27 55661
Affinity Capture-MS Homo sapiens
86 CEBPA  
Protein-peptide Homo sapiens
87 GTPBP4 23560
Affinity Capture-MS Homo sapiens
88 GLTSCR2  
Affinity Capture-MS Homo sapiens
89 C7orf50 84310
Affinity Capture-MS Homo sapiens
90 RPF1  
Affinity Capture-MS Homo sapiens
91 LARP1 23367
Affinity Capture-MS Homo sapiens
92 RSL1D1 26156
Affinity Capture-MS Homo sapiens
93 UTP20 27340
Affinity Capture-MS Homo sapiens
94 RHBDD1 84236
Affinity Capture-MS Homo sapiens
95 BMS1  
Affinity Capture-MS Homo sapiens
96 SPATS2L 26010
Affinity Capture-MS Homo sapiens
97 NOC3L 64318
Affinity Capture-MS Homo sapiens
98 AGPAT1 10554
Affinity Capture-MS Homo sapiens
99 SDC1 6382
Affinity Capture-MS Homo sapiens
100 POP1 10940
Affinity Capture-MS Homo sapiens
101 EXOSC10 5394
Affinity Capture-MS Homo sapiens
102 NAT10 55226
Affinity Capture-MS Homo sapiens
103 PNP 4860
Affinity Capture-MS Homo sapiens
104 WHSC1 7468
Affinity Capture-MS Homo sapiens
105 WDR3  
Affinity Capture-MS Homo sapiens
106 ISG20L2 81875
Affinity Capture-MS Homo sapiens
107 EBNA1BP2 10969
Affinity Capture-MS Homo sapiens
108 PAPD5 64282
Affinity Capture-MS Homo sapiens
109 DHX30 22907
Affinity Capture-MS Homo sapiens
110 PDCD11 22984
Affinity Capture-MS Homo sapiens
111 RRP15  
Affinity Capture-MS Homo sapiens
112 RPP30 10556
Affinity Capture-MS Homo sapiens
113 UTP15 84135
Affinity Capture-MS Homo sapiens
114 DKC1 1736
Affinity Capture-MS Homo sapiens
115 DDX47 51202
Affinity Capture-MS Homo sapiens
116 CEBPZ  
Affinity Capture-MS Homo sapiens
117 EXOSC3 51010
Affinity Capture-MS Homo sapiens
118 HP1BP3 50809
Affinity Capture-MS Homo sapiens
119 SKIV2L2 23517
Affinity Capture-MS Homo sapiens
120 RCN2 5955
Affinity Capture-MS Homo sapiens
121 PLS3 5358
Affinity Capture-MS Homo sapiens
122 ZC3HAV1 56829
Affinity Capture-MS Homo sapiens
123 NOP16 51491
Affinity Capture-MS Homo sapiens
124 NOL6 65083
Affinity Capture-MS Homo sapiens
125 DDX52  
Affinity Capture-MS Homo sapiens
126 FTSJ3 117246
Affinity Capture-MS Homo sapiens
127 LARP4 113251
Affinity Capture-MS Homo sapiens
128 GNL3 26354
Affinity Capture-MS Homo sapiens
129 NGDN  
Affinity Capture-MS Homo sapiens
130 H2AFX 3014
Affinity Capture-MS Homo sapiens
131 RRP7A 27341
Affinity Capture-MS Homo sapiens
132 ARPC3 10094
Affinity Capture-MS Homo sapiens
133 DDX50 79009
Affinity Capture-MS Homo sapiens
134 SURF6  
Affinity Capture-MS Homo sapiens
135 NVL  
Affinity Capture-MS Homo sapiens
136 CCDC86  
Affinity Capture-MS Homo sapiens
137 RRS1 23212
Affinity Capture-MS Homo sapiens
138 C9orf114  
Affinity Capture-MS Homo sapiens
139 NOL10  
Affinity Capture-MS Homo sapiens
140 MNDA 4332
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 USP36  
Affinity Capture-MS Homo sapiens
142 BOP1 23246
Affinity Capture-MS Homo sapiens
143 PRMT7  
Two-hybrid Homo sapiens
144 LENG8  
Affinity Capture-MS Homo sapiens
145 URB1 9875
Affinity Capture-MS Homo sapiens
146 SMIM8  
Affinity Capture-MS Homo sapiens
147 SSBP2  
Affinity Capture-MS Homo sapiens
148 CAPRIN1 4076
Affinity Capture-MS Homo sapiens
149 NSA2  
Affinity Capture-MS Homo sapiens
150 STRBP 55342
Affinity Capture-MS Homo sapiens
151 MKI67  
Affinity Capture-MS Homo sapiens
152 NIFK 84365
Affinity Capture-MS Homo sapiens
153 PWP1 11137
Affinity Capture-MS Homo sapiens
154 KRR1 11103
Affinity Capture-MS Homo sapiens
155 LARP7 51574
Affinity Capture-MS Homo sapiens
156 NOC2L 26155
Affinity Capture-MS Homo sapiens
157 ZNF711  
Affinity Capture-MS Homo sapiens
158 MOV10 4343
Affinity Capture-MS Homo sapiens
159 KLK10 5655
Affinity Capture-MS Homo sapiens
160 YTHDC2 64848
Affinity Capture-MS Homo sapiens
161 UPF1 5976
Affinity Capture-MS Homo sapiens
162 C14orf169  
Affinity Capture-MS Homo sapiens
163 GLYR1 84656
Affinity Capture-MS Homo sapiens
164 PPAN 56342
Affinity Capture-MS Homo sapiens
165 GNB2L1 10399
Affinity Capture-MS Homo sapiens
166 NOL9 79707
Affinity Capture-MS Homo sapiens
167 RBM34  
Affinity Capture-MS Homo sapiens
168 TEX10 54881
Affinity Capture-MS Homo sapiens
169 NOP10 55505
Affinity Capture-MS Homo sapiens
170 CYP3A43  
Affinity Capture-MS Homo sapiens
171 CASC3  
Affinity Capture-MS Homo sapiens
172 RRP1 8568
Affinity Capture-MS Homo sapiens
173 XRN2 22803
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MNDA is involved
PathwayEvidenceSource
Immune System TAS Reactome
Innate Immune System TAS Reactome
Neutrophil degranulation TAS Reactome





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