Gene description for POLR1C
Gene name polymerase (RNA) I polypeptide C, 30kDa
Gene symbol POLR1C
Other names/aliases RPA39
RPA40
RPA5
RPAC1
TCS3
Species Homo sapiens
 Database cross references - POLR1C
ExoCarta ExoCarta_9533
Vesiclepedia VP_9533
Entrez Gene 9533
HGNC 20194
MIM 610060
UniProt O15160  
 POLR1C identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Thymus 23844026    
 Gene ontology annotations for POLR1C
Molecular Function
    RNA polymerase I activity GO:0001054 IBA
    RNA polymerase III activity GO:0001056 IBA
    DNA binding GO:0003677 IEA
    DNA-directed 5'-3' RNA polymerase activity GO:0003899 TAS
    protein binding GO:0005515 IPI
    protein dimerization activity GO:0046983 IEA
Biological Process
    transcription by RNA polymerase I GO:0006360 TAS
    transcription by RNA polymerase III GO:0006383 IEA
Subcellular Localization
    fibrillar center GO:0001650 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    RNA polymerase III complex GO:0005666 IBA
    RNA polymerase III complex GO:0005666 IDA
    RNA polymerase I complex GO:0005736 IBA
    RNA polymerase I complex GO:0005736 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified POLR1C in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
10
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
15
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
19
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for POLR1C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAIP  
Two-hybrid Homo sapiens
2 HNRNPH1 3187
Two-hybrid Homo sapiens
3 MORN3  
Two-hybrid Homo sapiens
4 RIT1 6016
Negative Genetic Homo sapiens
5 POLR2G 5436
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
6 DDX24 57062
Co-fractionation Homo sapiens
7 RRN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 PMS1  
Affinity Capture-Western Homo sapiens
9 CCDC36  
Two-hybrid Homo sapiens
10 KIAA0020 9933
Co-fractionation Homo sapiens
11 FAM208B 54906
Two-hybrid Homo sapiens
12 NOP9 161424
Co-fractionation Homo sapiens
13 AES 166
Two-hybrid Homo sapiens
14 RPAP2  
Affinity Capture-MS Homo sapiens
15 FMR1 2332
Two-hybrid Homo sapiens
16 SPERT  
Two-hybrid Homo sapiens
17 RPL13A 23521
Co-fractionation Homo sapiens
18 KPNB1 3837
Affinity Capture-MS Homo sapiens
19 UXT 8409
Affinity Capture-MS Homo sapiens
20 NDUFB10 4716
Two-hybrid Homo sapiens
21 XPA  
Two-hybrid Homo sapiens
22 BYSL 705
Co-fractionation Homo sapiens
23 UBC 7316
Affinity Capture-MS Homo sapiens
24 SSB 6741
Co-fractionation Homo sapiens
25 KPNA2 3838
Affinity Capture-MS Homo sapiens
26 CFL1 1072
Co-fractionation Homo sapiens
27 WDR36 134430
Co-fractionation Homo sapiens
28 URI1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 USP36  
Affinity Capture-MS Homo sapiens
30 PFDN2 5202
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 HOXB9  
Two-hybrid Homo sapiens
32 RBM48  
Two-hybrid Homo sapiens
33 POLR3G  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
34 WDR76  
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
35 TSC22D4 81628
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
36 CORO1B 57175
Two-hybrid Homo sapiens
37 ROCK2 9475
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 CRACR2A  
Two-hybrid Homo sapiens
39 DYNC1LI2 1783
Proximity Label-MS Homo sapiens
40 KIF23 9493
Affinity Capture-MS Homo sapiens
41 MYO5B 4645
Two-hybrid Homo sapiens
42 WDR20 91833
Affinity Capture-MS Homo sapiens
43 CPSF4  
Affinity Capture-MS Homo sapiens
44 POLR2I 5438
Affinity Capture-MS Homo sapiens
45 NMD3 51068
Co-fractionation Homo sapiens
46 TRIOBP 11078
Two-hybrid Homo sapiens
47 FBXW7  
Affinity Capture-MS Homo sapiens
48 PRC1 9055
Affinity Capture-MS Homo sapiens
49 MRPS23 51649
Two-hybrid Homo sapiens
50 TWISTNB  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 FOXR2  
Two-hybrid Homo sapiens
52 E2F4  
Affinity Capture-MS Homo sapiens
53 POLR1E  
Affinity Capture-MS Homo sapiens
Far Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 KLF15  
Two-hybrid Homo sapiens
55 RUVBL1 8607
Co-fractionation Homo sapiens
56 WASH1 100287171
Two-hybrid Homo sapiens
57 POLR3B 55703
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
58 CRCP  
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 DDX18 8886
Co-fractionation Homo sapiens
60 POLR2C 5432
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
61 GPN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 CTPS1 1503
Co-fractionation Homo sapiens
63 POLR2M  
Affinity Capture-MS Homo sapiens
64 NMT1 4836
Co-fractionation Homo sapiens
65 ZNF554  
Two-hybrid Homo sapiens
66 PFDN6 10471
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 SMARCA2 6595
Co-fractionation Homo sapiens
68 NIF3L1 60491
Two-hybrid Homo sapiens
69 KCTD13 253980
Two-hybrid Homo sapiens
70 TAX1BP1 8887
Two-hybrid Homo sapiens
71 KIF14 9928
Affinity Capture-MS Homo sapiens
72 GAR1 54433
Co-fractionation Homo sapiens
73 GPN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 WRN 7486
Affinity Capture-Western Homo sapiens
75 POLR2K  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 GOLGA6L9  
Two-hybrid Homo sapiens
77 ADAMTSL4  
Two-hybrid Homo sapiens
78 CHMP4C 92421
Affinity Capture-MS Homo sapiens
79 MEI4  
Two-hybrid Homo sapiens
80 C4orf45  
Two-hybrid Homo sapiens
81 FUCA2 2519
Affinity Capture-MS Homo sapiens
82 DLD 1738
Affinity Capture-MS Homo sapiens
83 HERPUD2  
Affinity Capture-MS Homo sapiens
84 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
85 POLR3F  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
86 USP11 8237
Affinity Capture-MS Homo sapiens
87 KIF20A 10112
Affinity Capture-MS Homo sapiens
88 POLR3K  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 PARK2  
Affinity Capture-MS Homo sapiens
90 CLU 1191
Two-hybrid Homo sapiens
91 CCDC33 80125
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
92 LRIF1  
Two-hybrid Homo sapiens
93 SPSB3  
Affinity Capture-MS Homo sapiens
94 CCT3 7203
Two-hybrid Homo sapiens
95 BDP1  
Affinity Capture-MS Homo sapiens
96 TRIM14 9830
Two-hybrid Homo sapiens
97 ABCF2 10061
Co-fractionation Homo sapiens
98 PTPN21 11099
Affinity Capture-MS Homo sapiens
99 EP300 2033
Affinity Capture-MS Homo sapiens
100 CNOT1 23019
Co-fractionation Homo sapiens
101 YAP1 10413
Affinity Capture-MS Homo sapiens
102 SRBD1  
Affinity Capture-MS Homo sapiens
103 HDX  
Two-hybrid Homo sapiens
104 NTRK1 4914
Affinity Capture-MS Homo sapiens
105 IFI16 3428
Affinity Capture-MS Homo sapiens
106 ZNF547  
Two-hybrid Homo sapiens
107 NRBF2  
Affinity Capture-MS Homo sapiens
108 PPP2R3C  
Two-hybrid Homo sapiens
109 MEOX2  
Two-hybrid Homo sapiens
110 FBXL6  
Affinity Capture-MS Homo sapiens
111 DDX1 1653
Co-fractionation Homo sapiens
112 RIMBP3C  
Two-hybrid Homo sapiens
113 HECTD1 25831
Affinity Capture-MS Homo sapiens
114 POLR2B 5431
Affinity Capture-MS Homo sapiens
115 POLR3GL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 GTPBP4 23560
Co-fractionation Homo sapiens
117 ZNF688  
Two-hybrid Homo sapiens
118 ZBED1  
Two-hybrid Homo sapiens
119 TEX43  
Two-hybrid Homo sapiens
120 CD3EAP  
Co-fractionation Homo sapiens
Far Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 DNAJC7 7266
Proximity Label-MS Homo sapiens
122 ARRB1 408
Affinity Capture-MS Homo sapiens
123 CGGBP1 8545
Two-hybrid Homo sapiens
124 CIRBP 1153
Co-fractionation Homo sapiens
125 BRF1  
Affinity Capture-MS Homo sapiens
126 GMPPB 29925
Two-hybrid Homo sapiens
127 C1orf105  
Two-hybrid Homo sapiens
128 FANCD2  
Affinity Capture-MS Homo sapiens
129 POLR3A 11128
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 POLR2H 5437
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 TP53BP1 7158
Co-fractionation Homo sapiens
132 GOLGA6A  
Two-hybrid Homo sapiens
133 MAF1  
Affinity Capture-MS Homo sapiens
134 SPATC1L  
Two-hybrid Homo sapiens
135 SMARCA5 8467
Co-fractionation Homo sapiens
136 IKZF3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
137 CTNNB1 1499
Affinity Capture-MS Homo sapiens
138 POLR2E 5434
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
139 KRT75 9119
Two-hybrid Homo sapiens
140 RPRD2  
Affinity Capture-MS Homo sapiens
141 GAS8  
Two-hybrid Homo sapiens
142 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 CIT 11113
Affinity Capture-MS Homo sapiens
144 DCAF13 25879
Co-fractionation Homo sapiens
145 USP54 159195
Two-hybrid Homo sapiens
146 EBNA1BP2 10969
Co-fractionation Homo sapiens
147 ZNF835  
Two-hybrid Homo sapiens
148 ATRIP  
Two-hybrid Homo sapiens
149 POLR2D  
Affinity Capture-MS Homo sapiens
150 EP400  
Two-hybrid Homo sapiens
151 KRTAP12-2  
Two-hybrid Homo sapiens
152 BCCIP 56647
Co-fractionation Homo sapiens
153 DHX37  
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
154 RIPK4  
Affinity Capture-MS Homo sapiens
155 POLR3E 55718
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
156 FN1 2335
Affinity Capture-MS Homo sapiens
157 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
158 TBP  
Affinity Capture-MS Homo sapiens
159 ZNF655  
Two-hybrid Homo sapiens
160 LZTS2 84445
Two-hybrid Homo sapiens
161 MAPK6  
Affinity Capture-MS Homo sapiens
162 TRMT1L 81627
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
163 DKC1 1736
Co-fractionation Homo sapiens
164 DDX47 51202
Co-fractionation Homo sapiens
165 NME1 4830
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
166 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
167 SPRY1 10252
Two-hybrid Homo sapiens
168 HOXD12  
Two-hybrid Homo sapiens
169 TRIM27  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
170 RPAP3 79657
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
171 POLR1A  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
172 SORBS3 10174
Two-hybrid Homo sapiens
173 CORO1A 11151
Two-hybrid Homo sapiens
174 HYOU1 10525
Co-fractionation Homo sapiens
175 SMN1 6606
Two-hybrid Homo sapiens
176 KRAS 3845
Negative Genetic Homo sapiens
177 ZC2HC1C  
Two-hybrid Homo sapiens
178 KRT19 3880
Two-hybrid Homo sapiens
179 TSR1 55720
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
180 NFATC2  
Affinity Capture-MS Homo sapiens
181 POLR2A 5430
Affinity Capture-MS Homo sapiens
182 C9orf72  
Affinity Capture-MS Homo sapiens
183 HUWE1 10075
Affinity Capture-MS Homo sapiens
184 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
185 KRTAP3-1  
Two-hybrid Homo sapiens
186 ARRB2 409
Affinity Capture-MS Homo sapiens
187 POLR2J3  
Two-hybrid Homo sapiens
188 STMN3  
Two-hybrid Homo sapiens
189 POLR2F  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
190 PARP1 142
Proximity Label-MS Homo sapiens
191 EFHC2  
Two-hybrid Homo sapiens
192 POLR2J  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
193 POLR1B 84172
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
194 C21orf58  
Two-hybrid Homo sapiens
195 BHLHB9 80823
Two-hybrid Homo sapiens
196 EIF3I 8668
Co-fractionation Homo sapiens
197 RUVBL2 10856
Affinity Capture-MS Homo sapiens
198 POLR2L 5441
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
199 TNFAIP1 7126
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
200 POLR3C 10623
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
201 FAM154A  
Two-hybrid Homo sapiens
202 WDR92 116143
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
203 POLR3H  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
204 BLZF1  
Two-hybrid Homo sapiens
205 RPAP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
206 PIH1D2  
Two-hybrid Homo sapiens
207 TRMT61B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
208 AVPI1  
Two-hybrid Homo sapiens
209 MKRN3  
Two-hybrid Homo sapiens
210 GRPEL1 80273
Two-hybrid Homo sapiens
211 SMN2 6607
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
212 TAF1D  
Affinity Capture-MS Homo sapiens
213 TMEM121  
Two-hybrid Homo sapiens
214 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
215 PSMA1 5682
Two-hybrid Homo sapiens
216 ZIM2  
Two-hybrid Homo sapiens
217 PDZD11 51248
Affinity Capture-MS Homo sapiens
218 NME4 4833
Two-hybrid Homo sapiens
219 TCF4  
Two-hybrid Homo sapiens
220 MBIP  
Two-hybrid Homo sapiens
221 NCL 4691
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
222 EIF4B 1975
Co-fractionation Homo sapiens
223 RTCB 51493
Co-fractionation Homo sapiens
224 RUSC1  
Two-hybrid Homo sapiens
225 POLR3D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
226 CBX8 57332
Two-hybrid Homo sapiens
227 MYD88 4615
Two-hybrid Homo sapiens
228 BIN3 55909
Two-hybrid Homo sapiens
229 PSMB7 5695
Co-fractionation Homo sapiens
230 RPRD1B 58490
Affinity Capture-MS Homo sapiens
231 RIMBP3 85376
Two-hybrid Homo sapiens
232 C1QBP 708
Co-fractionation Homo sapiens
233 PIH1D1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
234 ZNRD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
235 PTGES3 10728
Affinity Capture-MS Homo sapiens
236 KRT76 51350
Two-hybrid Homo sapiens
237 KCTD1 284252
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
238 POLR1D 51082
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
239 BIRC7  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
240 ZBTB42  
Two-hybrid Homo sapiens
241 VIM 7431
Two-hybrid Homo sapiens
242 INCA1  
Two-hybrid Homo sapiens
243 ZFP57  
Two-hybrid Homo sapiens
244 PDRG1  
Affinity Capture-MS Homo sapiens
245 RPRD1A  
Affinity Capture-MS Homo sapiens
246 NSUN5  
Co-fractionation Homo sapiens
247 TNNI1 7135
Two-hybrid Homo sapiens
248 SNX3 8724
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which POLR1C is involved
PathwayEvidenceSource
B-WICH complex positively regulates rRNA expression TAS Reactome
Cytosolic sensors of pathogen-associated DNA TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Immune System TAS Reactome
Innate Immune System TAS Reactome
Negative epigenetic regulation of rRNA expression IEA Reactome
NoRC negatively regulates rRNA expression IEA Reactome
Positive epigenetic regulation of rRNA expression TAS Reactome
RNA Polymerase I Promoter Clearance TAS Reactome
RNA Polymerase I Promoter Clearance IEA Reactome
RNA Polymerase I Promoter Escape TAS Reactome
RNA Polymerase I Transcription TAS Reactome
RNA Polymerase I Transcription IEA Reactome
RNA Polymerase I Transcription Initiation TAS Reactome
RNA Polymerase I Transcription Initiation IEA Reactome
RNA Polymerase I Transcription Termination TAS Reactome
RNA Polymerase III Abortive And Retractive Initiation IEA Reactome
RNA Polymerase III Chain Elongation IEA Reactome
RNA Polymerase III Transcription IEA Reactome
RNA Polymerase III Transcription TAS Reactome
RNA Polymerase III Transcription Initiation IEA Reactome
RNA Polymerase III Transcription Initiation TAS Reactome
RNA Polymerase III Transcription Initiation From Type 1 Promoter IEA Reactome
RNA Polymerase III Transcription Initiation From Type 1 Promoter TAS Reactome
RNA Polymerase III Transcription Initiation From Type 2 Promoter IEA Reactome
RNA Polymerase III Transcription Initiation From Type 2 Promoter TAS Reactome
RNA Polymerase III Transcription Initiation From Type 3 Promoter IEA Reactome
RNA Polymerase III Transcription Initiation From Type 3 Promoter TAS Reactome
RNA Polymerase III Transcription Termination IEA Reactome





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