Gene description for AAMP
Gene name angio-associated, migratory cell protein
Gene symbol AAMP
Other names/aliases -
Species Homo sapiens
 Database cross references - AAMP
ExoCarta ExoCarta_14
Vesiclepedia VP_14
Entrez Gene 14
HGNC 18
MIM 603488
UniProt Q13685  
 AAMP identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocytes 26054723    
 Gene ontology annotations for AAMP
Molecular Function
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IDA
Biological Process
    angiogenesis GO:0001525 NAS
    positive regulation of endothelial cell migration GO:0010595 ISS
    smooth muscle cell migration GO:0014909 IEP
    cell differentiation GO:0030154 IEA
Subcellular Localization
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IEA
    cell surface GO:0009986 IDA
    microtubule cytoskeleton GO:0015630 IDA
    intercellular bridge GO:0045171 IDA
 Experiment description of studies that identified AAMP in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for AAMP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TBXA2R 6915
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
2 WNK1 65125
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
4 ARGLU1  
Affinity Capture-MS Homo sapiens
5 C8orf33 65265
Two-hybrid Homo sapiens
6 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
7 UBE2H 7328
Affinity Capture-MS Homo sapiens
8 PAXIP1  
Affinity Capture-MS Homo sapiens
9 TP53BP1 7158
Affinity Capture-MS Homo sapiens
10 NR3C1 2908
Proximity Label-MS Homo sapiens
11 RIN3  
Affinity Capture-MS Homo sapiens
12 AEN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
13 RNF128  
Affinity Capture-MS Homo sapiens
14 SRP9 6726
Co-fractionation Homo sapiens
15 VPS52 6293
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
16 PDCD4 27250
Co-fractionation Homo sapiens
17 GABARAPL2 11345
Two-hybrid Homo sapiens
18 RPL10 6134
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 PTF1A  
Two-hybrid Homo sapiens
20 PRPF40A 55660
Affinity Capture-MS Homo sapiens
21 BHLHE40  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 EGFR 1956
Affinity Capture-MS Homo sapiens
23 CWF19L2  
Affinity Capture-MS Homo sapiens
24 PARK2  
Affinity Capture-MS Homo sapiens
25 ACE2 59272
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 RSRC1  
Affinity Capture-MS Homo sapiens
27 PSEN2 5664
Two-hybrid Homo sapiens
28 SRSF6 6431
Affinity Capture-MS Homo sapiens
29 MAP1LC3B 81631
Two-hybrid Homo sapiens
30 XPO1 7514
Affinity Capture-MS Homo sapiens
31 C9orf78 51759
Affinity Capture-MS Homo sapiens
32 INPP5K 51763
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 CCDC9  
Affinity Capture-MS Homo sapiens
34 DKC1 1736
Affinity Capture-MS Homo sapiens
35 SERBP1 26135
Affinity Capture-MS Homo sapiens
36 FXR2 9513
Affinity Capture-MS Homo sapiens
37 OGT 8473
Reconstituted Complex Homo sapiens
38 HSF1  
Co-fractionation Homo sapiens
39 DHPS 1725
Co-fractionation Homo sapiens
40 PLIN3 10226
Co-fractionation Homo sapiens
41 DICER1  
Affinity Capture-MS Homo sapiens
42 EP300 2033
Affinity Capture-MS Homo sapiens
43 KRAS 3845
Synthetic Lethality Homo sapiens
Negative Genetic Homo sapiens
44 C9orf72  
Affinity Capture-MS Homo sapiens
45 SUB1 10923
Affinity Capture-MS Homo sapiens
46 PTPRU  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 ATOH1  
Affinity Capture-MS Homo sapiens
48 SSRP1 6749
Affinity Capture-MS Homo sapiens
49 RHOA 387
Affinity Capture-Western Homo sapiens
50 MKLN1  
Affinity Capture-MS Homo sapiens
51 PMFBP1 83449
Affinity Capture-MS Homo sapiens
52 PPP2R2D 55844
Affinity Capture-MS Homo sapiens
53 C11orf57  
Two-hybrid Homo sapiens
54 SUPT16H 11198
Affinity Capture-MS Homo sapiens
55 ASAH1 427
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 TULP3 7289
Affinity Capture-MS Homo sapiens
57 MMADHC  
Affinity Capture-MS Homo sapiens
58 TCF25 22980
Affinity Capture-MS Homo sapiens
59 TK1 7083
Two-hybrid Homo sapiens
View the network image/svg+xml



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