Gene description for MPP2
Gene name membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
Gene symbol MPP2
Other names/aliases DLG2
Species Homo sapiens
 Database cross references - MPP2
ExoCarta ExoCarta_4355
Vesiclepedia VP_4355
Entrez Gene 4355
HGNC 7220
MIM 600723
UniProt Q14168  
 MPP2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MPP2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    protein homooligomerization GO:0051260 ISS
    excitatory postsynaptic potential GO:0060079 ISS
    long-term synaptic potentiation GO:0060291 ISS
Subcellular Localization
    cytoplasm GO:0005737 IEA
    cytoskeleton GO:0005856 IDA
    plasma membrane GO:0005886 IBA
    cell-cell junction GO:0005911 IBA
    postsynaptic density GO:0014069 ISS
    dendrite membrane GO:0032590 ISS
    dendritic spine GO:0043197 ISS
    dendritic shaft GO:0043198 ISS
 Experiment description of studies that identified MPP2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MPP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MPP6 51678
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 Mbp 17196
Protein-peptide Mus musculus
3 CUL1 8454
Affinity Capture-MS Homo sapiens
4 CSNK2B 1460
Two-hybrid Homo sapiens
5 PRKY  
Affinity Capture-MS Homo sapiens
6 LIN7C 55327
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
7 MTPN 136319
Affinity Capture-MS Homo sapiens
8 CDA 978
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 MAPK1 5594
Affinity Capture-MS Homo sapiens
10 ISOC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 NF2 4771
Affinity Capture-MS Homo sapiens
12 DLG1 1739
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 TUBB8 347688
Affinity Capture-MS Homo sapiens
14 CYP2S1  
Affinity Capture-MS Homo sapiens
15 NGB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 GID4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 ARMC12  
Affinity Capture-MS Homo sapiens
18 MAGEA9  
Affinity Capture-MS Homo sapiens
19 ARMC8 25852
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 LIN7A 8825
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
21 MMAB 326625
Affinity Capture-MS Homo sapiens
22 ABLIM1 3983
Affinity Capture-MS Homo sapiens
23 LIN7B  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 PLK1 5347
Two-hybrid Homo sapiens
25 ZER1 10444
Affinity Capture-MS Homo sapiens
26 PTGES3 10728
Affinity Capture-MS Homo sapiens
27 SLC20A1 6574
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 CCT8L2  
Affinity Capture-MS Homo sapiens
29 THRSP  
Affinity Capture-MS Homo sapiens
30 CEBPA  
Affinity Capture-MS Homo sapiens
31 CDC5L 988
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MPP2 is involved
No pathways found





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