Gene description for MC1R
Gene name	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Gene symbol	MC1R
Other names/aliases	CMM5 MSH-R SHEP2
Species	Homo sapiens
Database cross references - MC1R
ExoCarta	ExoCarta_4157
Vesiclepedia	VP_4157
Entrez Gene	4157
HGNC	6929
MIM	155555
UniProt	Q01726
MC1R identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for MC1R

Molecular Function     melanocortin receptor activity GO:0004977 TAS     melanocyte-stimulating hormone receptor activity GO:0004980 IBA     melanocyte-stimulating hormone receptor activity GO:0004980 IPI     protein binding GO:0005515 IPI     G protein-coupled peptide receptor activity GO:0008528 TAS     ubiquitin protein ligase binding GO:0031625 IPI     hormone binding GO:0042562 IEA Biological Process     G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 TAS     adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IBA     adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IDA     phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 ISS     UV protection GO:0009650 TAS     regulation of metabolic process GO:0019222 IBA     sensory perception of pain GO:0019233 IEA     negative regulation of tumor necrosis factor production GO:0032720 IMP     intracellular signal transduction GO:0035556 ISS     melanin biosynthetic process GO:0042438 IEA     pigmentation GO:0043473 TAS     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     UV-damage excision repair GO:0070914 IDA     positive regulation of cAMP/PKA signal transduction GO:0141163 ISS     positive regulation of feeding behavior GO:2000253 IEA Subcellular Localization     cytoplasm GO:0005737 IBA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS