Gene description for PRKCA
Gene name	protein kinase C, alpha
Gene symbol	PRKCA
Other names/aliases	AAG6 PKC-alpha PKCA PRKACA
Species	Homo sapiens
Database cross references - PRKCA
ExoCarta	ExoCarta_5578
Entrez Gene	5578
HGNC	9393
MIM	176960
UniProt	P17252
PRKCA identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723
Neuroblastoma cells	25944692
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Platelets	25332113
Platelets	25332113
Platelets	25332113
Urine	19056867

Gene ontology annotations for PRKCA

Molecular Function     protein binding GO:0005515 IPI     protein kinase activity GO:0004672 IDA     ATP binding GO:0005524 IEA     protein kinase C activity GO:0004697 ISS     protein serine/threonine kinase activity GO:0004674 TAS     calcium-dependent protein kinase C activity GO:0004698 IEA     histone kinase activity (H3-T6 specific) GO:0035403 IDA     zinc ion binding GO:0008270 IEA     enzyme binding GO:0019899 IDA Biological Process     chondrocyte differentiation GO:0002062 IEA     cellular calcium ion homeostasis GO:0006874 IEA     activation of phospholipase C activity GO:0007202 TAS     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS     negative regulation of glial cell apoptotic process GO:0034351 IMP     positive regulation of inflammatory response GO:0050729 IEA     protein phosphorylation GO:0006468 IDA     induction of positive chemotaxis GO:0050930 IEA     platelet activation GO:0030168 TAS     positive regulation of mitotic cell cycle GO:0045931 IMP     negative regulation of adenylate cyclase activity GO:0007194 ISS     positive regulation of cell adhesion GO:0045785 IMP     regulation of rhodopsin mediated signaling pathway GO:0022400 TAS     inactivation of MAPK activity GO:0000188 IEA     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     angiogenesis GO:0001525 IEA     positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666 IMP     extracellular matrix organization GO:0030198 TAS     mitotic cell cycle GO:0000278 TAS     innate immune response GO:0045087 TAS     negative regulation of insulin receptor signaling pathway GO:0046627 IEA     positive regulation of dense core granule biogenesis GO:2000707 ISS     blood coagulation GO:0007596 TAS     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     phototransduction, visible light GO:0007603 TAS     positive regulation of macrophage differentiation GO:0045651 ISS     peptidyl-serine autophosphorylation GO:0036289 IEA     signal transduction GO:0007165 TAS     cell adhesion GO:0007155 IEA     regulation of peptidyl-tyrosine phosphorylation GO:0050730 IEA     positive regulation of cardiac muscle hypertrophy GO:0010613 ISS     response to interleukin-1 GO:0070555 IMP     energy reserve metabolic process GO:0006112 TAS     positive regulation of endothelial cell migration GO:0010595 IMP     negative regulation of glucose import GO:0046325 IEA     positive regulation of angiogenesis GO:0045766 IMP     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     intrinsic apoptotic signaling pathway GO:0097193 IEA     negative regulation of cell proliferation GO:0008285 IEA     neutrophil chemotaxis GO:0030593 IEA     desmosome assembly GO:0002159 IMP     positive regulation of blood vessel endothelial cell migration GO:0043536 IDA     regulation of platelet aggregation GO:0090330 IDA     positive regulation of endothelial cell proliferation GO:0001938 IMP     histone H3-T6 phosphorylation GO:0035408 IDA     activation of adenylate cyclase activity GO:0007190 ISS     regulation of the force of heart contraction GO:0002026 IEA     positive regulation of cell migration GO:0030335 IMP     apoptotic signaling pathway GO:0097190 TAS     mitotic nuclear envelope disassembly GO:0007077 TAS     rhodopsin mediated signaling pathway GO:0016056 TAS     small molecule metabolic process GO:0044281 TAS     gene expression GO:0010467 TAS     regulation of insulin secretion GO:0050796 TAS     epidermal growth factor receptor signaling pathway GO:0007173 TAS     synaptic transmission GO:0007268 TAS     cellular response to carbohydrate stimulus GO:0071322 IEA     regulation of muscle contraction GO:0006937 IEA Subcellular Localization     perinuclear region of cytoplasm GO:0048471 ISS     mitochondrial membrane GO:0031966 IEA     extracellular exosome GO:0070062 IDA     cytosol GO:0005829 TAS     nucleoplasm GO:0005654 TAS     photoreceptor outer segment GO:0001750 IEA     apical part of cell GO:0045177 IEA     mitochondrion GO:0005739 IDA     cytoplasm GO:0005737 IDA     neuronal cell body GO:0043025 IEA     dendrite GO:0030425 IEA     plasma membrane GO:0005886 TAS     endoplasmic reticulum GO:0005783 IDA