Gene description for COL4A3BP
Gene name collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
Gene symbol COL4A3BP
Other names/aliases CERT
CERTL
GPBP
MRD34
STARD11
Species Homo sapiens
 Database cross references - COL4A3BP
ExoCarta ExoCarta_10087
Vesiclepedia VP_10087
Entrez Gene 10087
HGNC 2205
MIM 604677
UniProt Q9Y5P4  
 COL4A3BP identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for COL4A3BP
Molecular Function
    protein binding GO:0005515 IPI
    kinase activity GO:0016301 IEA
    identical protein binding GO:0042802 IPI
    phosphatidylinositol-4-phosphate binding GO:0070273 IDA
    ceramide binding GO:0097001 IDA
    ceramide transfer activity GO:0120017 IDA
    ceramide 1-phosphate binding GO:1902387 IBA
    ceramide 1-phosphate transfer activity GO:1902388 IBA
Biological Process
    cell morphogenesis GO:0000902 IEA
    in utero embryonic development GO:0001701 IEA
    heart morphogenesis GO:0003007 IEA
    ceramide metabolic process GO:0006672 IEA
    muscle contraction GO:0006936 IEA
    immune response GO:0006955 NAS
    mitochondrion organization GO:0007005 IEA
    endoplasmic reticulum organization GO:0007029 IEA
    signal transduction GO:0007165 IEA
    cell population proliferation GO:0008283 IEA
    response to endoplasmic reticulum stress GO:0034976 IEA
    ER to Golgi ceramide transport GO:0035621 IGI
    ER to Golgi ceramide transport GO:0035621 IMP
    ceramide transport GO:0035627 IBA
    lipid homeostasis GO:0055088 IEA
    intermembrane lipid transfer GO:0120009 IBA
    intermembrane lipid transfer GO:0120009 IEA
    intermembrane sphingolipid transfer GO:0120012 IDA
    ceramide 1-phosphate transport GO:1902389 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 IEA
    endoplasmic reticulum membrane GO:0005789 TAS
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 TAS
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified COL4A3BP in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for COL4A3BP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CBS 875
Two-hybrid Homo sapiens
2 FTL 2512
Co-fractionation Homo sapiens
3 MARK3 4140
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 MARK1 4139
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CALR 811
Co-fractionation Homo sapiens
6 AQP2 359
Two-hybrid Homo sapiens
7 EBAG9 9166
Proximity Label-MS Homo sapiens
8 SFN 2810
Affinity Capture-MS Homo sapiens
9 IFT20 90410
Affinity Capture-MS Homo sapiens
10 KIAA0226L  
Affinity Capture-MS Homo sapiens
11 RTN3 10313
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
12 PPP2R5C 5527
Co-fractionation Homo sapiens
13 TRAF7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 CSNK1G2 1455
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
15 PACSIN2 11252
Co-fractionation Homo sapiens
16 PTPN9 5780
Affinity Capture-MS Homo sapiens
17 RPL14 9045
Affinity Capture-MS Homo sapiens
18 POM121  
Two-hybrid Homo sapiens
19 RUFY1 80230
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 ARL6IP1 23204
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
21 TAF15 8148
Affinity Capture-MS Homo sapiens
22 ENTPD7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 RTN4 57142
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
24 SMU1 55234
Two-hybrid Homo sapiens
25 PM20D2 135293
Two-hybrid Homo sapiens
26 TGM2 7052
Two-hybrid Homo sapiens
27 ITGB3BP  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
28 MARK2 2011
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 BSND  
Two-hybrid Homo sapiens
30 RPL38 6169
Affinity Capture-MS Homo sapiens
31 ACTL8  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
32 KIAA1024  
Two-hybrid Homo sapiens
33 EXOSC3 51010
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 SLC13A2 9058
Affinity Capture-MS Homo sapiens
35 SF3B1 23451
Co-fractionation Homo sapiens
36 REEP6  
Two-hybrid Homo sapiens
37 PNMA2  
Co-fractionation Homo sapiens
38 COL4A3BP 10087
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
39 PARP1 142
Proximity Label-MS Homo sapiens
40 PTAR1 375743
Synthetic Lethality Homo sapiens
41 RANGAP1 5905
Co-fractionation Homo sapiens
42 EYA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 RANBP2 5903
Co-fractionation Homo sapiens
44 NAP1L5  
Co-fractionation Homo sapiens
45 STX2 2054
Two-hybrid Homo sapiens
46 STXBP3 6814
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which COL4A3BP is involved
PathwayEvidenceSource
Metabolism TAS Reactome
Metabolism of lipids TAS Reactome
Sphingolipid de novo biosynthesis TAS Reactome
Sphingolipid metabolism TAS Reactome





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