Gene description for SH3GLB1
Gene name SH3-domain GRB2-like endophilin B1
Gene symbol SH3GLB1
Other names/aliases Bif-1
CGI-61
PPP1R70
dJ612B15.2
Species Homo sapiens
 Database cross references - SH3GLB1
ExoCarta ExoCarta_51100
Entrez Gene 51100
HGNC 10833
MIM 609287
UniProt Q9Y371  
 SH3GLB1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SH3GLB1
Molecular Function
    lipid binding GO:0008289 IEA
    protein homodimerization activity GO:0042803 IPI
    identical protein binding GO:0042802 IPI
    protein binding GO:0005515 IPI
Biological Process
    receptor catabolic process GO:0032801 IMP
    cellular response to amino acid starvation GO:0034198 IMP
    apoptotic process GO:0006915 IEA
    cellular response to glucose starvation GO:0042149 IMP
    protein localization to vacuolar membrane GO:1903778 IMP
    positive regulation of protein targeting to mitochondrion GO:1903955 IMP
    autophagic cell death GO:0048102 IMP
    positive regulation of autophagy GO:0010508 IMP
    positive regulation of membrane tubulation GO:1903527 IMP
    regulation of protein stability GO:0031647 IMP
    positive regulation of autophagosome assembly GO:2000786 IMP
    regulation of cytokinesis GO:0032465 IMP
    protein oligomerization GO:0051259 IDA
    membrane fission GO:0090148 IMP
    positive regulation of protein oligomerization GO:0032461 IDA
Subcellular Localization
    mitochondrial outer membrane GO:0005741 IEA
    Golgi membrane GO:0000139 IEA
    extracellular exosome GO:0070062 IDA
    midbody GO:0030496 IDA
    autophagosome membrane GO:0000421 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified SH3GLB1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SH3GLB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SH3GLB2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 ARHGAP17 55114
Reconstituted Complex Homo sapiens
3 HTT 3064
Reconstituted Complex Homo sapiens
4 Map4k3  
Reconstituted Complex Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
Reconstituted Complex Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
5 SH3KBP1 30011
Reconstituted Complex Homo sapiens
6 DNM1 1759
Reconstituted Complex Homo sapiens
7 BAX 581
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
8 AMPH  
Reconstituted Complex Homo sapiens
9 BIN1 274
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which SH3GLB1 is involved
No pathways found





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