Gene description for TAP1
Gene name transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Gene symbol TAP1
Other names/aliases ABC17
ABCB2
APT1
D6S114E
PSF-1
PSF1
RING4
TAP1*0102N
TAP1N
Species Homo sapiens
 Database cross references - TAP1
ExoCarta ExoCarta_6890
Entrez Gene 6890
HGNC 43
MIM 170260
UniProt Q03518  
 TAP1 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Thymus 23844026    
 Gene ontology annotations for TAP1
Molecular Function
    peptide transporter activity GO:0015197 IMP
    protein binding GO:0005515 IPI
    MHC class I protein binding GO:0042288 IEA
    TAP2 binding GO:0046979 IPI
    ADP binding GO:0043531 IDA
    protein homodimerization activity GO:0042803 ISS
    MHC class Ib protein binding GO:0023029 IPI
    peptide-transporting ATPase activity GO:0015440 IEA
    ATP binding GO:0005524 IDA
    peptide antigen binding GO:0042605 NAS
    TAP1 binding GO:0046978 ISS
    ATPase activity, coupled to transmembrane movement of substances GO:0042626 IBA
Biological Process
    antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590 TAS
    defense response GO:0006952 IEA
    metabolic process GO:0008152 IEA
    intracellular transport of viral protein in host cell GO:0019060 IMP
    antigen processing and presentation of peptide antigen via MHC class I GO:0002474 TAS
    transmembrane transport GO:0055085 IBA
    cytosol to ER transport GO:0046967 IMP
    antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 IMP
    antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 TAS
    peptide transport GO:0015833 IMP
Subcellular Localization
    mitochondrion GO:0005739 IEA
    membrane GO:0016020 IDA
    TAP complex GO:0042825 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    integral component of endoplasmic reticulum membrane GO:0030176 IDA
    host cell GO:0043657 IMP
    integral component of membrane GO:0016021 IDA
 Experiment description of studies that identified TAP1 in exosomes
1
Experiment ID 231
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TAP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HLA-F  
Affinity Capture-MS Homo sapiens
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