Gene description for TAP1
Gene name transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Gene symbol TAP1
Other names/aliases ABC17
ABCB2
APT1
D6S114E
PSF-1
PSF1
RING4
TAP1*0102N
TAP1N
Species Homo sapiens
 Database cross references - TAP1
ExoCarta ExoCarta_6890
Vesiclepedia VP_6890
Entrez Gene 6890
HGNC 43
MIM 170260
UniProt Q03518  
 TAP1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Thymus 23844026    
 Gene ontology annotations for TAP1
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
    ATP binding GO:0005524 IMP
    ABC-type peptide antigen transporter activity GO:0015433 IBA
    ABC-type peptide antigen transporter activity GO:0015433 IDA
    ABC-type peptide antigen transporter activity GO:0015433 IGI
    ABC-type peptide antigen transporter activity GO:0015433 IMP
    ATP hydrolysis activity GO:0016887 IEA
    MHC class Ib protein binding GO:0023029 IPI
    MHC class I protein binding GO:0042288 IEA
    peptide antigen binding GO:0042605 IDA
    peptide antigen binding GO:0042605 NAS
    protein homodimerization activity GO:0042803 ISS
    ADP binding GO:0043531 IDA
    metal ion binding GO:0046872 IEA
    TAP1 binding GO:0046978 IBA
    TAP1 binding GO:0046978 ISS
    TAP2 binding GO:0046979 IPI
    peptide transmembrane transporter activity GO:1904680 IMP
Biological Process
    adaptive immune response GO:0002250 IEA
    defense response GO:0006952 IEA
    protein transport GO:0015031 IEA
    peptide transport GO:0015833 IMP
    antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 IBA
    antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 IDA
    antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 IMP
    cytosol to endoplasmic reticulum transport GO:0046967 IMP
    transmembrane transport GO:0055085 IBA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    membrane GO:0016020 HDA
    membrane GO:0016020 IBA
    membrane GO:0016020 IDA
    phagocytic vesicle membrane GO:0030670 TAS
    endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 TAS
    centriolar satellite GO:0034451 IDA
    MHC class I peptide loading complex GO:0042824 IBA
    MHC class I peptide loading complex GO:0042824 IDA
    TAP complex GO:0042825 IDA
 Experiment description of studies that identified TAP1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TAP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 OR2M7  
Affinity Capture-MS Homo sapiens
2 HMOX1 3162
Affinity Capture-MS Homo sapiens
3 Tmed2 56334
Affinity Capture-MS Mus musculus
4 ISG15 9636
Affinity Capture-MS Homo sapiens
5 SLC10A6  
Two-hybrid Homo sapiens
6 VAPA 9218
Affinity Capture-MS Homo sapiens
7 ATG5 9474
Proximity Label-MS Homo sapiens
8 LCE2C  
Two-hybrid Homo sapiens
9 TMEM184A  
Affinity Capture-MS Homo sapiens
10 IGHM 3507
Affinity Capture-MS Homo sapiens
11 BSCL2  
Affinity Capture-MS Homo sapiens
12 MDFI  
Two-hybrid Homo sapiens
13 TMEM9B 56674
Affinity Capture-MS Homo sapiens
14 LTN1 26046
Affinity Capture-MS Homo sapiens
15 FFAR1  
Affinity Capture-MS Homo sapiens
16 PSMB8 5696
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
17 KIAA1429 25962
Affinity Capture-MS Homo sapiens
18 KRTAP4-12  
Two-hybrid Homo sapiens
19 INSRR 3645
Affinity Capture-MS Homo sapiens
20 FAM57A  
Affinity Capture-MS Homo sapiens
21 CCDC8  
Affinity Capture-MS Homo sapiens
22 GDI1 2664
Affinity Capture-MS Homo sapiens
23 TDP2 51567
Two-hybrid Homo sapiens
24 ABCD3 5825
Co-fractionation Homo sapiens
25 PIGH  
Affinity Capture-MS Homo sapiens
26 COPG1 22820
Affinity Capture-Western Homo sapiens
27 PDIA2 64714
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
28 CCDC47 57003
Affinity Capture-MS Homo sapiens
29 GRPR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 F2RL1  
Affinity Capture-MS Homo sapiens
31 CALR 811
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
32 SSMEM1  
Two-hybrid Homo sapiens
33 HLA-G 3135
Affinity Capture-Western Homo sapiens
34 TMEM63B 55362
Affinity Capture-MS Homo sapiens
35 Ar  
Affinity Capture-MS Mus musculus
36 TMEM25  
Affinity Capture-MS Homo sapiens
37 CHRM3 1131
Two-hybrid Homo sapiens
38 EFNA5  
Affinity Capture-MS Homo sapiens
39 TMEM14B  
Two-hybrid Homo sapiens
40 P2RY8  
Affinity Capture-MS Homo sapiens
41 SRSF3 6428
Co-fractionation Homo sapiens
42 GPR35  
Affinity Capture-MS Homo sapiens
43 COPB1 1315
Affinity Capture-Western Homo sapiens
44 Sidt2  
Affinity Capture-MS Mus musculus
45 ERVFRD-1  
Two-hybrid Homo sapiens
46 GPR182  
Affinity Capture-MS Homo sapiens
47 SSUH2  
Affinity Capture-MS Homo sapiens
48 CREB3  
Two-hybrid Homo sapiens
49 CYC1 1537
Co-fractionation Homo sapiens
50 PML 5371
Affinity Capture-MS Homo sapiens
51 SLC33A1 9197
Affinity Capture-MS Homo sapiens
52 TAP2 6891
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
53 GAPDHS 26330
Affinity Capture-MS Homo sapiens
54 Rab5c 19345
Affinity Capture-MS Mus musculus
55 MRPL40 64976
Co-fractionation Homo sapiens
56 APLNR  
Affinity Capture-MS Homo sapiens
57 VAPB 9217
Affinity Capture-MS Homo sapiens
58 CANX 821
Affinity Capture-MS Homo sapiens
59 ATL3 25923
Affinity Capture-MS Homo sapiens
60 SDHA 6389
Co-fractionation Homo sapiens
61 HMOX2 3163
Affinity Capture-MS Homo sapiens
62 Bmpr1a  
Affinity Capture-MS Mus musculus
63 B3GNT3 10331
Affinity Capture-MS Homo sapiens
64 CHRNA1  
Affinity Capture-MS Homo sapiens
65 ERGIC3 51614
Two-hybrid Homo sapiens
66 MGARP  
Affinity Capture-MS Homo sapiens
67 HSD3B7 80270
Proximity Label-MS Homo sapiens
68 GPR12  
Affinity Capture-MS Homo sapiens
69 MBOAT1  
Affinity Capture-MS Homo sapiens
70 PDIA3 2923
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
71 KLRD1  
Affinity Capture-MS Homo sapiens
72 GADD45GIP1  
Co-fractionation Homo sapiens
73 AQP3  
Affinity Capture-MS Homo sapiens
74 GPR152  
Two-hybrid Homo sapiens
75 GEMIN4 50628
Two-hybrid Homo sapiens
76 TSPAN8 7103
Affinity Capture-MS Homo sapiens
77 Tubgcp5  
Affinity Capture-MS Mus musculus
78 GPR45  
Affinity Capture-MS Homo sapiens
79 CMTM5  
Affinity Capture-MS Homo sapiens
80 DLST 1743
Affinity Capture-MS Homo sapiens
81 SLC10A1  
Two-hybrid Homo sapiens
82 XRCC3  
Affinity Capture-MS Homo sapiens
83 ISLR 3671
Affinity Capture-MS Homo sapiens
84 SLC22A4 6583
Affinity Capture-MS Homo sapiens
85 HLA-A 3105
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
86 SLC22A9  
Affinity Capture-MS Homo sapiens
87 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
88 MUL1  
Two-hybrid Homo sapiens
89 TMEM9 252839
Affinity Capture-MS Homo sapiens
90 KCNA2  
Affinity Capture-MS Homo sapiens
91 MCAT 27349
Co-fractionation Homo sapiens
92 RNF19B  
Two-hybrid Homo sapiens
93 LDLRAD1  
Affinity Capture-MS Homo sapiens
94 MFSD4  
Affinity Capture-MS Homo sapiens
95 OPALIN  
Affinity Capture-MS Homo sapiens
96 SFXN1 94081
Co-fractionation Homo sapiens
97 AUP1 550
Affinity Capture-MS Homo sapiens
98 TAPBP 6892
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
99 BRICD5  
Affinity Capture-MS Homo sapiens
100 BCL2  
Affinity Capture-MS Homo sapiens
101 B2M 567
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
102 GOT1 2805
Affinity Capture-MS Homo sapiens
103 LPAR2 9170
Affinity Capture-MS Homo sapiens
104 VIPR1  
Affinity Capture-MS Homo sapiens
105 CLEC4E  
Affinity Capture-MS Homo sapiens
106 KIAA1644  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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