Gene description for TRAF3IP1
Gene name TNF receptor-associated factor 3 interacting protein 1
Gene symbol TRAF3IP1
Other names/aliases IFT54
MIP-T3
MIPT3
Species Homo sapiens
 Database cross references - TRAF3IP1
ExoCarta ExoCarta_26146
Vesiclepedia VP_26146
Entrez Gene 26146
HGNC 17861
MIM 607380
UniProt Q8TDR0  
 TRAF3IP1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TRAF3IP1
Molecular Function
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IEA
Biological Process
    morphogenesis of a polarized epithelium GO:0001738 IDA
    kidney development GO:0001822 IMP
    negative regulation of protein phosphorylation GO:0001933 IMP
    negative regulation of protein-containing complex assembly GO:0031333 IMP
    negative regulation of type I interferon production GO:0032480 IMP
    intraciliary anterograde transport GO:0035720 NAS
    intraciliary transport GO:0042073 IBA
    negative regulation of defense response to virus GO:0050687 IMP
    cilium assembly GO:0060271 IBA
    cilium assembly GO:0060271 NAS
    regulation of microtubule cytoskeleton organization GO:0070507 IBA
    regulation of microtubule cytoskeleton organization GO:0070507 IMP
Subcellular Localization
    cilium GO:0005929 NAS
    cilium GO:0005929 TAS
    axoneme GO:0005930 IBA
    intraciliary transport particle B GO:0030992 IBA
    intraciliary transport particle B GO:0030992 IPI
    intraciliary transport particle B GO:0030992 ISS
    ciliary transition zone GO:0035869 IDA
    ciliary basal body GO:0036064 IBA
    ciliary tip GO:0097542 IDA
    ciliary tip GO:0097542 TAS
    ciliary base GO:0097546 IDA
 Experiment description of studies that identified TRAF3IP1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TRAF3IP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SMC3 9126
Two-hybrid Homo sapiens
2 HSPA6 3310
Affinity Capture-MS Homo sapiens
3 PKM 5315
Affinity Capture-MS Homo sapiens
4 UBXN10  
Reconstituted Complex Homo sapiens
5 ACTC1 70
Affinity Capture-MS Homo sapiens
6 HSPA1L 3305
Affinity Capture-MS Homo sapiens
7 MAP4 4134
Affinity Capture-MS Homo sapiens
8 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
9 TTC30B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 CKB 1152
Affinity Capture-MS Homo sapiens
11 PGK1 5230
Affinity Capture-MS Homo sapiens
12 IFT74 80173
Affinity Capture-MS Homo sapiens
13 EXOC1 55763
Two-hybrid Homo sapiens
14 IFT88 8100
Affinity Capture-MS Homo sapiens
15 RPL24 6152
Affinity Capture-MS Homo sapiens
16 SMC2 10592
Two-hybrid Homo sapiens
17 Kif23 71819
Affinity Capture-MS Mus musculus
18 PHB 5245
Affinity Capture-MS Homo sapiens
19 GOLGA4  
Two-hybrid Homo sapiens
20 EEF1A1 1915
Affinity Capture-MS Homo sapiens
21 IFT20 90410
Affinity Capture-MS Homo sapiens
22 HSPA8 3312
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
23 SMC4 10051
Two-hybrid Homo sapiens
24 IFT27 11020
Affinity Capture-MS Homo sapiens
25 TAF10 6881
Affinity Capture-MS Homo sapiens
26 SFR1 119392
Two-hybrid Homo sapiens
27 SNAP91 9892
Two-hybrid Homo sapiens
28 ACTA1 58
Affinity Capture-MS Homo sapiens
29 DTNBP1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
30 TUBB2B 347733
Affinity Capture-MS Homo sapiens
31 MYH9 4627
Affinity Capture-MS Homo sapiens
32 ACTN4 81
Affinity Capture-MS Homo sapiens
33 KRT9 3857
Affinity Capture-MS Homo sapiens
34 TAB2  
Two-hybrid Homo sapiens
35 S100A8 6279
Affinity Capture-MS Homo sapiens
36 ZSCAN26  
Affinity Capture-MS Homo sapiens
37 IFT172 26160
Affinity Capture-MS Homo sapiens
38 CCDC101  
Two-hybrid Homo sapiens
39 NME8  
Affinity Capture-MS Homo sapiens
40 ACTG1 71
Affinity Capture-MS Homo sapiens
41 FRMD4A  
Two-hybrid Homo sapiens
42 DST 667
Two-hybrid Homo sapiens
43 DISC1 27185
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
44 ACTN1 87
Affinity Capture-MS Homo sapiens
45 TTC30A 92104
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 TUBB 203068
Affinity Capture-MS Homo sapiens
47 CCNA2 890
Two-hybrid Homo sapiens
48 AHCY 191
Affinity Capture-MS Homo sapiens
49 IFT57 55081
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 TRAF6 7189
Reconstituted Complex Homo sapiens
51 EGFR 1956
Affinity Capture-MS Homo sapiens
52 GTF3C2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 RPL7 6129
Affinity Capture-MS Homo sapiens
54 TRAF3 7187
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
55 SPTBN1 6711
Two-hybrid Homo sapiens
56 DMAP1 55929
Affinity Capture-MS Homo sapiens
57 ABTB2 25841
Affinity Capture-MS Homo sapiens
58 IFT46 56912
Affinity Capture-MS Homo sapiens
59 Uso1 56041
Affinity Capture-MS Mus musculus
60 SSNA1 8636
Affinity Capture-MS Homo sapiens
61 HSPA1A 3303
Affinity Capture-MS Homo sapiens
62 ACTB 60
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
63 PCM1 5108
Proximity Label-MS Homo sapiens
64 HSPA9 3313
Affinity Capture-MS Homo sapiens
65 WAC  
Two-hybrid Homo sapiens
66 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
67 PHGDH 26227
Affinity Capture-MS Homo sapiens
68 IFT22 64792
Affinity Capture-MS Homo sapiens
69 IMMT 10989
Two-hybrid Homo sapiens
70 TUBB2A 7280
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
71 TRAK1 22906
Two-hybrid Homo sapiens
72 BLOC1S2 282991
Affinity Capture-MS Homo sapiens
73 OLFM1  
Two-hybrid Homo sapiens
74 MACF1 23499
Two-hybrid Homo sapiens
75 CLUAP1 23059
Affinity Capture-MS Homo sapiens
76 KRT10 3858
Affinity Capture-MS Homo sapiens
77 HSPB11 51668
Affinity Capture-MS Homo sapiens
78 MAPRE2 10982
Affinity Capture-MS Homo sapiens
79 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
80 IFT80 57560
Affinity Capture-MS Homo sapiens
81 TRAP1 10131
Affinity Capture-MS Homo sapiens
82 ABI2 10152
Two-hybrid Homo sapiens
83 KXD1 79036
Affinity Capture-MS Homo sapiens
84 MAP1A 4130
Affinity Capture-MS Homo sapiens
85 DMD 1756
Two-hybrid Homo sapiens
86 CCDC93 54520
Two-hybrid Homo sapiens
87 C17orf59 54785
Proximity Label-MS Homo sapiens
88 CDC5L 988
Two-hybrid Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here