Gene description for ZFAND5
Gene name zinc finger, AN1-type domain 5
Gene symbol ZFAND5
Other names/aliases ZA20D2
Species Homo sapiens
 Database cross references - ZFAND5
ExoCarta ExoCarta_7763
Entrez Gene 7763
HGNC 13008
MIM 604761
UniProt O76080  
 ZFAND5 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Neuroblastoma cells 25944692    
 Gene ontology annotations for ZFAND5
Molecular Function
    zinc ion binding GO:0008270 IEA
    protein binding GO:0005515 IPI
    molecular_function GO:0003674 ND
    DNA binding GO:0003677 IEA
Biological Process
    face development GO:0060324 IEA
    fibroblast migration GO:0010761 IEA
    respiratory system process GO:0003016 IEA
    in utero embryonic development GO:0001701 IEA
    skeletal system morphogenesis GO:0048705 IEA
    smooth muscle tissue development GO:0048745 IEA
    biological_process GO:0008150 ND
    platelet-derived growth factor receptor signaling pathway GO:0048008 IEA
    vasculature development GO:0001944 IEA
Subcellular Localization
    cellular_component GO:0005575 ND
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified ZFAND5 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for ZFAND5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IKBKG 8517
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
2 TRAF6 7189
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which ZFAND5 is involved
No pathways found

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