Gene description for MAP2K6
Gene name	mitogen-activated protein kinase kinase 6
Gene symbol	MAP2K6
Other names/aliases	MAPKK6 MEK6 MKK6 PRKMK6 SAPKK-3 SAPKK3
Species	Homo sapiens
Database cross references - MAP2K6
ExoCarta	ExoCarta_5608
Entrez Gene	5608
HGNC	6846
MIM	601254
UniProt	P52564
MAP2K6 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Mesenchymal stem cells	Unpublished / Not applicable
Thymus	23844026

Gene ontology annotations for MAP2K6

Molecular Function     protein serine/threonine kinase activity GO:0004674 IBA     protein kinase binding GO:0019901 IPI     protein tyrosine kinase activity GO:0004713 IEA     ATP binding GO:0005524 IEA     MAP kinase kinase activity GO:0004708 IEA     protein binding GO:0005515 IPI Biological Process     cardiac muscle contraction GO:0060048 IEA     nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0035872 TAS     muscle cell differentiation GO:0042692 TAS     transcription, DNA-templated GO:0006351 IEA     apoptotic process GO:0006915 IEA     ovulation cycle process GO:0022602 IEA     signal transduction by protein phosphorylation GO:0023014 IBA     regulation of transcription, DNA-templated GO:0006355 IEA     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     innate immune response GO:0045087 TAS     regulation of mitotic cell cycle GO:0007346 IBA     toll-like receptor 2 signaling pathway GO:0034134 TAS     regulation of apoptotic process GO:0042981 IBA     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     toll-like receptor 9 signaling pathway GO:0034162 TAS     positive regulation of muscle cell differentiation GO:0051149 TAS     positive regulation of prostaglandin secretion GO:0032308 IEA     response to ischemia GO:0002931 IEA     cell cycle arrest GO:0007050 TAS     response to drug GO:0042493 IEA     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     signal transduction GO:0007165 TAS     nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 TAS     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     activation of MAPK activity GO:0000187 TAS     positive regulation of apoptotic process GO:0043065 IEA     stress-activated MAPK cascade GO:0051403 TAS     DNA damage induced protein phosphorylation GO:0006975 TAS     cellular response to sorbitol GO:0072709 IEA     toll-like receptor signaling pathway GO:0002224 TAS     toll-like receptor 3 signaling pathway GO:0034138 TAS     stress-activated protein kinase signaling cascade GO:0031098 IBA     toll-like receptor 4 signaling pathway GO:0034142 TAS     toll-like receptor 10 signaling pathway GO:0034166 TAS     peptidyl-tyrosine phosphorylation GO:0018108 IEA     positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 IEA     toll-like receptor 5 signaling pathway GO:0034146 TAS Subcellular Localization     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IBA     cytoskeleton GO:0005856 IEA     cytosol GO:0005829 TAS