Gene description for Bag6
Gene name BCL2-associated athanogene 6
Gene symbol Bag6
Other names/aliases Bat3
Species Rattus norvegicus
 Database cross references - Bag6
ExoCarta ExoCarta_94342
Vesiclepedia VP_94342
Entrez Gene 94342
UniProt Q6MG49  
 Bag6 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Bag6
Molecular Function
    signaling receptor binding GO:0005102 ISO
    protein binding GO:0005515 IPI
    Hsp70 protein binding GO:0030544 IEA
    Hsp70 protein binding GO:0030544 ISO
    polyubiquitin modification-dependent protein binding GO:0031593 IBA
    polyubiquitin modification-dependent protein binding GO:0031593 IEA
    polyubiquitin modification-dependent protein binding GO:0031593 ISO
    polyubiquitin modification-dependent protein binding GO:0031593 ISS
    ubiquitin protein ligase binding GO:0031625 IEA
    ubiquitin protein ligase binding GO:0031625 ISO
    identical protein binding GO:0042802 ISO
    ribosome binding GO:0043022 IEA
    ribosome binding GO:0043022 ISO
    ribosome binding GO:0043022 ISS
    receptor ligand activity GO:0048018 IEA
    receptor ligand activity GO:0048018 ISO
    misfolded protein binding GO:0051787 IBA
    misfolded protein binding GO:0051787 IEA
    misfolded protein binding GO:0051787 ISO
    molecular adaptor activity GO:0060090 ISO
    proteasome binding GO:0070628 IEA
    proteasome binding GO:0070628 ISO
    proteasome binding GO:0070628 ISS
    molecular function activator activity GO:0140677 ISO
    ubiquitin-specific protease binding GO:1990381 IEA
    ubiquitin-specific protease binding GO:1990381 ISO
Biological Process
    kidney development GO:0001822 IEA
    kidney development GO:0001822 ISO
    kidney development GO:0001822 ISS
    immune system process GO:0002376 IEA
    immune response-activating cell surface receptor signaling pathway GO:0002429 IEA
    immune response-activating cell surface receptor signaling pathway GO:0002429 ISO
    chromatin organization GO:0006325 IEA
    ubiquitin-dependent protein catabolic process GO:0006511 ISO
    ubiquitin-dependent protein catabolic process GO:0006511 ISS
    post-translational protein targeting to endoplasmic reticulum membrane GO:0006620 IEA
    post-translational protein targeting to endoplasmic reticulum membrane GO:0006620 ISO
    apoptotic process GO:0006915 IEA
    apoptotic process GO:0006915 ISO
    apoptotic process GO:0006915 ISS
    synaptonemal complex assembly GO:0007130 IEA
    synaptonemal complex assembly GO:0007130 ISO
    synaptonemal complex assembly GO:0007130 ISS
    spermatogenesis GO:0007283 IEA
    spermatogenesis GO:0007283 ISO
    spermatogenesis GO:0007283 ISS
    brain development GO:0007420 IEA
    brain development GO:0007420 ISO
    brain development GO:0007420 ISS
    proteasomal protein catabolic process GO:0010498 ISO
    proteasomal protein catabolic process GO:0010498 ISS
    internal peptidyl-lysine acetylation GO:0018393 ISO
    internal peptidyl-lysine acetylation GO:0018393 ISS
    natural killer cell activation GO:0030101 IEA
    natural killer cell activation GO:0030101 ISO
    cell differentiation GO:0030154 IEA
    lung development GO:0030324 IEA
    lung development GO:0030324 ISO
    lung development GO:0030324 ISS
    regulation of protein stability GO:0031647 ISO
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 IEA
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 ISO
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 ISS
    ERAD pathway GO:0036503 IBA
    ERAD pathway GO:0036503 IEA
    ERAD pathway GO:0036503 ISO
    ERAD pathway GO:0036503 ISS
    maintenance of unfolded protein GO:0036506 IEA
    maintenance of unfolded protein GO:0036506 ISO
    regulation of cell population proliferation GO:0042127 IEP
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 IEA
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 ISO
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 ISS
    regulation of apoptotic process GO:0042981 ISO
    negative regulation of apoptotic process GO:0043066 IEA
    negative regulation of apoptotic process GO:0043066 ISO
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IEA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO
    negative regulation of proteolysis GO:0045861 ISO
    negative regulation of proteolysis GO:0045861 ISS
    regulation of embryonic development GO:0045995 IEA
    regulation of embryonic development GO:0045995 ISO
    regulation of embryonic development GO:0045995 ISS
    protein stabilization GO:0050821 IEA
    protein stabilization GO:0050821 ISO
    protein stabilization GO:0050821 ISS
    NK T cell activation GO:0051132 IEA
    NK T cell activation GO:0051132 ISO
    endoplasmic reticulum stress-induced pre-emptive quality control GO:0061857 IEA
    endoplasmic reticulum stress-induced pre-emptive quality control GO:0061857 ISO
    endoplasmic reticulum stress-induced pre-emptive quality control GO:0061857 ISS
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 IEA
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 ISO
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 ISS
    tail-anchored membrane protein insertion into ER membrane GO:0071816 IEA
    tail-anchored membrane protein insertion into ER membrane GO:0071816 ISO
    tail-anchored membrane protein insertion into ER membrane GO:0071816 ISS
    positive regulation of ERAD pathway GO:1904294 IEA
    positive regulation of ERAD pathway GO:1904294 ISO
Subcellular Localization
    extracellular region GO:0005576 IEA
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    membrane GO:0016020 IEA
    membrane GO:0016020 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    extracellular exosome GO:0070062 IEA
    extracellular exosome GO:0070062 ISO
    BAT3 complex GO:0071818 IBA
    BAT3 complex GO:0071818 IEA
    BAT3 complex GO:0071818 ISO
    BAT3 complex GO:0071818 ISS
 Experiment description of studies that identified Bag6 in sEVs
1
Experiment ID 95
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 98
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Bag6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAF6 7189
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which Bag6 is involved
No pathways found





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