Gene description for NUMBL
Gene name numb homolog (Drosophila)-like
Gene symbol NUMBL
Other names/aliases CAG3A
CTG3a
NBL
NUMB-R
NUMBLIKE
NUMBR
TNRC23
Species Homo sapiens
 Database cross references - NUMBL
ExoCarta ExoCarta_9253
Entrez Gene 9253
HGNC 8061
MIM 604018
UniProt Q9Y6R0  
 NUMBL identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for NUMBL
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    nervous system development GO:0007399 TAS
    protein metabolic process GO:0019538 IDA
    positive regulation of dendrite morphogenesis GO:0050775 IEA
    neuroblast division in subventricular zone GO:0021849 ISS
    cytokine-mediated signaling pathway GO:0019221 IDA
    lateral ventricle development GO:0021670 ISS
    adherens junction organization GO:0034332 IEA
    positive regulation of neurogenesis GO:0050769 ISS
    axonogenesis GO:0007409 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified NUMBL in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NUMBL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EPS15 2060
Invitro Homo sapiens
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which NUMBL is involved
No pathways found





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