ExoCarta: Gene summary

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Gene description for RHOT2
Gene name	ras homolog family member T2
Gene symbol	RHOT2
Other names/aliases	ARHT2 C16orf39 MIRO-2 MIRO2 RASL
Species	Homo sapiens
Database cross references - RHOT2
ExoCarta	ExoCarta_89941
Vesiclepedia	VP_89941
Entrez Gene	89941
HGNC	21169
MIM	613889
UniProt	Q8IXI1
RHOT2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for RHOT2

Molecular Function
	GTPase activity	GO:0003924	IBA
	calcium ion binding	GO:0005509	IEA
	protein binding	GO:0005515	IPI
	GTP binding	GO:0005525	IBA
Biological Process
	mitochondrion organization	GO:0007005	IBA
	cellular homeostasis	GO:0019725	IMP
	mitochondrion transport along microtubule	GO:0047497	IBA
	mitochondrion transport along microtubule	GO:0047497	IMP
	mitochondrial outer membrane permeabilization	GO:0097345	IMP
Subcellular Localization
	mitochondrion	GO:0005739	HTP
	mitochondrion	GO:0005739	IDA
	mitochondrial outer membrane	GO:0005741	IBA
	mitochondrial outer membrane	GO:0005741	IDA
	mitochondrial outer membrane	GO:0005741	TAS
	membrane	GO:0016020	HDA

Experiment description of studies that identified RHOT2 in sEVs

Experiment ID

489

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 6

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

490

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 7

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

491

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

492

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 9

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

235

MISEV standards
✔ EM	Biophysical techniques
✔ TSG101\|Alix\|HSC70\|GAPDH	Enriched markers
✔ HSP90B1	Negative markers
✔ qNano	Particle analysis

Identified molecule

mRNA

Identification method

RNA Sequencing

PubMed ID

26054723

Organism

Homo sapiens

Experiment description

Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs

Authors

"He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"

Journal name

Carcinogenesis

Publication year

2015

Sample

Hepatocellular carcinoma cells

Sample name

HKCI-8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient

Flotation density

1.13-1.19 g/mL

Molecules identified in the study

Protein
RNA

Methods used in the study

Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing

Protein-protein interactions for RHOT2

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

SEC22B

9554

Proximity Label-MS

Homo sapiens

KIF16B

55614

Proximity Label-MS

Homo sapiens

AFG3L2

10939

Proximity Label-MS

Homo sapiens

RANBP6

26953

Proximity Label-MS

Homo sapiens

C1orf198

84886

Proximity Label-MS

Homo sapiens

SECISBP2

Proximity Label-MS

Homo sapiens

ANKLE2

23141

Proximity Label-MS

Homo sapiens

SPRTN

Affinity Capture-MS

Homo sapiens

MTCH1

23787

Proximity Label-MS

Homo sapiens

PROSER1

Proximity Label-MS

Homo sapiens

CENPE

1062

Proximity Label-MS

Homo sapiens

NDUFS1

4719

Co-fractionation

Homo sapiens

FBXL4

26235

Proximity Label-MS

Homo sapiens

KLK5

25818

Affinity Capture-MS

Homo sapiens

ALMS1

Proximity Label-MS

Homo sapiens

JPH1

56704

Proximity Label-MS

Homo sapiens

MARCH2

Proximity Label-MS

Homo sapiens

ARFGAP3

26286

Proximity Label-MS

Homo sapiens

CISD1

55847

Proximity Label-MS

Homo sapiens

KIF20A

10112

Affinity Capture-MS

Homo sapiens

UBC

7316

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

BNIP3L

Proximity Label-MS

Homo sapiens

VPS13C

54832

Proximity Label-MS

Homo sapiens

GRAMD1A

Proximity Label-MS

Homo sapiens

HNRNPR

10236

Co-fractionation

Homo sapiens

PTPN1

5770

Proximity Label-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

APBB1

Proximity Label-MS

Homo sapiens

TAF1

Affinity Capture-MS

Homo sapiens

FFAR1

Affinity Capture-MS

Homo sapiens

TACC2

10579

Proximity Label-MS

Homo sapiens

KIAA1671

Proximity Label-MS

Homo sapiens

SMIM12

Proximity Label-MS

Homo sapiens

APEX1

328

Affinity Capture-RNA

Homo sapiens

KIAA1429

25962

Affinity Capture-MS

Homo sapiens

TIMMDC1

Proximity Label-MS

Homo sapiens

PPTC7

160760

Affinity Capture-MS

Homo sapiens

VTA1

51534

Proximity Label-MS

Homo sapiens

FIS1

51024

Proximity Label-MS

Homo sapiens

MRPL20

55052

Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

NDUFS3

4722

Proximity Label-MS

Homo sapiens

B3GNT2

10678

Affinity Capture-MS

Homo sapiens

STBD1

8987

Proximity Label-MS

Homo sapiens

SMCR8

140775

Proximity Label-MS

Homo sapiens

COQ9

Affinity Capture-MS

Homo sapiens

EIF4ENIF1

56478

Proximity Label-MS

Homo sapiens

DNAJC11

55735

Proximity Label-MS

Homo sapiens

NAV1

89796

Proximity Label-MS

Homo sapiens

CHMP5

51510

Proximity Label-MS

Homo sapiens

SPAG9

9043

Proximity Label-MS

Homo sapiens

ARMCX4

Proximity Label-MS

Homo sapiens

RAB3B

5865

Proximity Label-MS

Homo sapiens

CENPF

1063

Proximity Label-MS

Homo sapiens

TRABD

80305

Proximity Label-MS

Homo sapiens

MARCH1

Proximity Label-MS

Homo sapiens

ABCD3

5825

Proximity Label-MS

Homo sapiens

DDRGK1

65992

Proximity Label-MS

Homo sapiens

MARCH5

Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CHCHD3

54927

Proximity Label-MS

Homo sapiens

VPS13D

55187

Proximity Label-MS

Homo sapiens

NXPH1

Affinity Capture-MS

Homo sapiens

LSG1

Proximity Label-MS

Homo sapiens

PGRMC2

10424

Proximity Label-MS

Homo sapiens

EXD2

Proximity Label-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

FIGNL1

63979

Proximity Label-MS

Homo sapiens

SUN1

23353

Proximity Label-MS

Homo sapiens

SLC25A46

91137

Proximity Label-MS

Homo sapiens

WDFY3

23001

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RHOT1

55288

Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

F2RL1

Affinity Capture-MS

Homo sapiens

BTAF1

9044

Affinity Capture-MS

Homo sapiens

ZC3HAV1

56829

Proximity Label-MS

Homo sapiens

MAVS

57506

Proximity Label-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

HSD17B4

3295

Proximity Label-MS

Homo sapiens

FAM73A

Proximity Label-MS

Homo sapiens

ESYT2

57488

Proximity Label-MS

Homo sapiens

FAF2

23197

Proximity Label-MS

Homo sapiens

ZFYVE9

Two-hybrid

Homo sapiens

RAVER1

125950

Proximity Label-MS

Homo sapiens

ATP6AP1

537

Proximity Label-MS

Homo sapiens

ARMCX3

51566

Proximity Label-MS

Homo sapiens

VIPAS39

63894

Proximity Label-MS

Homo sapiens

KIF14

9928

Affinity Capture-MS

Homo sapiens

EXOC4

60412

Proximity Label-MS

Homo sapiens

EMC1

23065

Proximity Label-MS

Homo sapiens

CAMLG

819

Proximity Label-MS

Homo sapiens

BUB1

Proximity Label-MS

Homo sapiens

PALD1

27143

Proximity Label-MS

Homo sapiens

DDX19B

11269

Affinity Capture-MS

Homo sapiens

PXMP2

Proximity Label-MS

Homo sapiens

CHMP4C

92421

Affinity Capture-MS

Homo sapiens

EFNA2

Affinity Capture-MS

Homo sapiens

KIAA1217

56243

Proximity Label-MS

Homo sapiens

TNRC6C

Proximity Label-MS

Homo sapiens

PUS1

80324

Proximity Label-MS

Homo sapiens

VEZT

55591

Proximity Label-MS

Homo sapiens

MTCH2

23788

Proximity Label-MS

Homo sapiens

SCFD1

23256

Proximity Label-MS

Homo sapiens

TMEM14B

Two-hybrid

Homo sapiens

SMPD4

55627

Proximity Label-MS

Homo sapiens

100

SAMM50

25813

Co-fractionation		Homo sapiens
Proximity Label-MS		Homo sapiens

101

RABL3

285282

Proximity Label-MS

Homo sapiens

102

RPL9

6133

Co-fractionation

Homo sapiens

103

PARK2

Affinity Capture-MS		Homo sapiens
Biochemical Activity		Homo sapiens
Affinity Capture-MS		Homo sapiens

104

FUNDC2

65991

Proximity Label-MS

Homo sapiens

105

MTFR1L

56181

Proximity Label-MS

Homo sapiens

106

C2CD4C

Proximity Label-MS

Homo sapiens

107

ATPAF1

Proximity Label-MS

Homo sapiens

108

ACIN1

22985

Co-fractionation

Homo sapiens

109

SNAP47

116841

Proximity Label-MS

Homo sapiens

110

DIABLO

56616

Proximity Label-MS

Homo sapiens

111

LARP4

113251

Proximity Label-MS

Homo sapiens

112

TBC1D32

221322

Proximity Label-MS

Homo sapiens

113

NDUFS8

4728

Co-fractionation

Homo sapiens

114

RAB13

5872

Proximity Label-MS

Homo sapiens

115

SLAIN1

122060

Proximity Label-MS

Homo sapiens

116

CLCC1

23155

Proximity Label-MS

Homo sapiens

117

MTX3

Proximity Label-MS

Homo sapiens

118

S1PR1

1901

Affinity Capture-MS

Homo sapiens

119

NXPH2

Affinity Capture-MS

Homo sapiens

120

BCL2L13

23786

Proximity Label-MS

Homo sapiens

121

MLX

Proximity Label-MS

Homo sapiens

122

MIA3

375056

Proximity Label-MS

Homo sapiens

123

Proximity Label-MS

Homo sapiens

124

MTDH

92140

Proximity Label-MS

Homo sapiens

125

TACC1

6867

Proximity Label-MS

Homo sapiens

126

PREB

10113

Proximity Label-MS

Homo sapiens

127

DHX9

1660

Co-fractionation

Homo sapiens

128

STX5

6811

Proximity Label-MS

Homo sapiens

129

TECR

9524

Co-fractionation

Homo sapiens

130

ATP6AP2

10159

Proximity Label-MS

Homo sapiens

131

ZCCHC11

23318

Proximity Label-MS

Homo sapiens

132

CCDC47

57003

Proximity Label-MS

Homo sapiens

133

MFF

56947

Proximity Label-MS

Homo sapiens

134

ARMCX2

9823

Proximity Label-MS

Homo sapiens

135

SLC33A1

9197

Proximity Label-MS

Homo sapiens

136

RMDN3

55177

Proximity Label-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

137

SP100

6672

Affinity Capture-MS

Homo sapiens

138

FAM188B

Proximity Label-MS

Homo sapiens

139

GOLGA3

2802

Proximity Label-MS

Homo sapiens

140

TEX2

55852

Proximity Label-MS

Homo sapiens

141

ANLN

54443

Affinity Capture-MS

Homo sapiens

142

OXA1L

Co-fractionation

Homo sapiens

143

DST

667

Proximity Label-MS

Homo sapiens

144

CCDC115

84317

Proximity Label-MS

Homo sapiens

145

NTRK1

4914

Affinity Capture-MS

Homo sapiens

146

CYB5B

80777

Proximity Label-MS

Homo sapiens

147

FAM83B

Proximity Label-MS

Homo sapiens

148

APLNR

Affinity Capture-MS

Homo sapiens

149

IPO5

3843

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

150

EMC3

55831

Proximity Label-MS

Homo sapiens

151

VAPB

9217

Proximity Label-MS

Homo sapiens

152

AIFM1

9131

Proximity Label-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

153

RPS2

6187

Co-fractionation

Homo sapiens

154

EMC8

10328

Proximity Label-MS

Homo sapiens

155

RAB5A

5868

Co-fractionation

Homo sapiens

156

CDCA3

83461

Proximity Label-MS

Homo sapiens

157

ATP2B2

491

Affinity Capture-MS

Homo sapiens

158

CDKAL1

Proximity Label-MS

Homo sapiens

159

MTX2

10651

Proximity Label-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

160

SARM1

23098

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

161

TRPM7

54822

Proximity Label-MS

Homo sapiens

162

EEF2

1938

Co-fractionation

Homo sapiens

163

PRKAR2A

5576

Proximity Label-MS

Homo sapiens

164

BRD8

10902

Affinity Capture-MS

Homo sapiens

165

MGARP

Affinity Capture-MS

Homo sapiens

166

RAB29

8934

Proximity Label-MS

Homo sapiens

167

CUL3

8452

Affinity Capture-MS

Homo sapiens

168

NR3C1

2908

Proximity Label-MS

Homo sapiens

169

STIM1

6786

Proximity Label-MS

Homo sapiens

170

SRSF5

6430

Co-fractionation

Homo sapiens

171

SYNE1

23345

Proximity Label-MS

Homo sapiens

172

FKBP8

23770

Proximity Label-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

173

MYO19

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

174

FBXO6

26270

Affinity Capture-MS

Homo sapiens

175

MTFR1

Proximity Label-MS

Homo sapiens

176

MTFR2

Proximity Label-MS

Homo sapiens

177

RIPK4

Affinity Capture-MS

Homo sapiens

178

EHBP1

23301

Proximity Label-MS

Homo sapiens

179

SASS6

163786

Proximity Label-MS

Homo sapiens

180

SGPP1

81537

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

181

OCIAD1

54940

Proximity Label-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

182

C17orf80

55028

Proximity Label-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

183

SCYL2

55681

Proximity Label-MS

Homo sapiens

184

PEX14

5195

Proximity Label-MS

Homo sapiens

185

TMEM86B

Two-hybrid

Homo sapiens

186

PRKACA

5566

Proximity Label-MS

Homo sapiens

187

UBXN4

23190

Proximity Label-MS

Homo sapiens

188

SOAT1

6646

Proximity Label-MS

Homo sapiens

189

ACSL3

2181

Proximity Label-MS

Homo sapiens

190

AAAS

8086

Proximity Label-MS

Homo sapiens

191

CNR2

Affinity Capture-MS

Homo sapiens

192

RPA3

6119

Proximity Label-MS

Homo sapiens

193

PEX11B

8799

Proximity Label-MS

Homo sapiens

194

EMC2

9694

Proximity Label-MS

Homo sapiens

195

GPR45

Affinity Capture-MS

Homo sapiens

196

PEX1

5189

Proximity Label-MS

Homo sapiens

197

IMMT

10989

Proximity Label-MS

Homo sapiens

198

VRK2

7444

Proximity Label-MS

Homo sapiens

199

RPN1

6184

Proximity Label-MS

Homo sapiens

200

MFN2

9927

Proximity Label-MS

Homo sapiens

201

AHNAK2

113146

Proximity Label-MS

Homo sapiens

202

RNF2

Affinity Capture-MS

Homo sapiens

203

CRYBG3

Proximity Label-MS

Homo sapiens

204

ILK

3611

Affinity Capture-MS

Homo sapiens

205

HAX1

Proximity Label-MS

Homo sapiens

206

TMEM209

84928

Proximity Label-MS

Homo sapiens

207

LEMD3

Proximity Label-MS

Homo sapiens

208

AKAP1

8165

Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

209

NUP133

55746

Proximity Label-MS

Homo sapiens

210

ACBD5

91452

Proximity Label-MS

Homo sapiens

211

VMA21

Proximity Label-MS

Homo sapiens

212

HK2

3099

Proximity Label-MS

Homo sapiens

213

TTC17

55761

Proximity Label-MS

Homo sapiens

214

TRAK2

66008

Affinity Capture-MS

Homo sapiens

215

PLEKHA4

57664

Affinity Capture-MS

Homo sapiens

216

PHB2

11331

Proximity Label-MS

Homo sapiens

217

ALDH3A2

224

Proximity Label-MS

Homo sapiens

218

NUP107

57122

Proximity Label-MS

Homo sapiens

219

TRIM13

Proximity Label-MS

Homo sapiens

220

PARP1

142

Proximity Label-MS

Homo sapiens

221

WDR41

Proximity Label-MS

Homo sapiens

222

TMEM57

Proximity Label-MS

Homo sapiens

223

TRAK1

22906

Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

224

DOCK5

80005

Affinity Capture-MS

Homo sapiens

225

MTMR3

Proximity Label-MS

Homo sapiens

226

PEX19

5824

Proximity Label-MS

Homo sapiens

227

PDCL

5082

Proximity Label-MS

Homo sapiens

228

DNAJA2

10294

Proximity Label-MS

Homo sapiens

229

TPTE

Affinity Capture-MS

Homo sapiens

230

VPS33B

26276

Proximity Label-MS

Homo sapiens

231

VAPA

9218

Proximity Label-MS

Homo sapiens

232

RYK

6259

Affinity Capture-MS

Homo sapiens

233

FKRP

79147

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

234

LMAN1

3998

Proximity Label-MS

Homo sapiens

235

NDUFS7

374291

Co-fractionation

Homo sapiens

236

ITPR3

3710

Proximity Label-MS

Homo sapiens

237

CHCHD4

Co-fractionation

Homo sapiens

238

TTK

7272

Proximity Label-MS

Homo sapiens

239

EIF4A3

9775

Co-fractionation

Homo sapiens

240

TOR1AIP1

26092

Proximity Label-MS

Homo sapiens

241

PRKAR2B

5577

Proximity Label-MS

Homo sapiens

242

ATP6V1F

9296

Proximity Label-MS

Homo sapiens

243

RPS26

6231

Co-fractionation

Homo sapiens

244

PDZD8

118987

Proximity Label-MS

Homo sapiens

245

AUP1

550

Proximity Label-MS

Homo sapiens

246

RAB8A

4218

Proximity Label-MS

Homo sapiens

247

PTPN5

Affinity Capture-MS

Homo sapiens

248

USP30

Proximity Label-MS

Homo sapiens

249

DNM1L

10059

Proximity Label-MS

Homo sapiens

250

TSHR

7253

Affinity Capture-MS

Homo sapiens

251

C20orf195

Affinity Capture-MS

Homo sapiens

252

INF2

64423

Proximity Label-MS

Homo sapiens

253

NDC1

55706

Proximity Label-MS

Homo sapiens

254

TDRKH

Proximity Label-MS

Homo sapiens

255

SPCS3

60559

Proximity Label-MS

Homo sapiens

256

HK1

3098

Proximity Label-MS

Homo sapiens

257

C19orf52

Proximity Label-MS

Homo sapiens

258

PINK1

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

259

YKT6

10652

Proximity Label-MS

Homo sapiens

260

HNRNPF

3185

Co-fractionation

Homo sapiens

261

PRR11

Proximity Label-MS

Homo sapiens

262

XPR1

9213

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

263

PEX5

5830

Proximity Label-MS

Homo sapiens

264

C9orf72

Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

265

LRRC49

Proximity Label-MS

Homo sapiens

266

CKAP4

10970

Proximity Label-MS

Homo sapiens

267

SPTBN5

51332

Proximity Label-MS

Homo sapiens

268

PLD6

Proximity Label-MS

Homo sapiens

269

SP7

Affinity Capture-MS

Homo sapiens

270

ARMC10

83787

Proximity Label-MS

Homo sapiens

271

ESYT1

23344

Proximity Label-MS

Homo sapiens

272

ASB14

Affinity Capture-MS

Homo sapiens

273

SNAP29

9342

Proximity Label-MS

Homo sapiens

274

CHMP7

91782

Proximity Label-MS

Homo sapiens

275

DKKL1

Affinity Capture-MS

Homo sapiens

View the network

Pathways in which RHOT2 is involved

Pathway	Evidence	Source
Miro GTPase Cycle	IEA	Reactome
Miro GTPase Cycle	TAS	Reactome
RHOT2 GTPase cycle	IEA	Reactome
RHOT2 GTPase cycle	TAS	Reactome
Signal Transduction	IEA	Reactome
Signal Transduction	TAS	Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	IEA	Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	TAS	Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here