Gene description for RHOT2
Gene name ras homolog family member T2
Gene symbol RHOT2
Other names/aliases ARHT2
C16orf39
MIRO-2
MIRO2
RASL
Species Homo sapiens
 Database cross references - RHOT2
ExoCarta ExoCarta_89941
Vesiclepedia VP_89941
Entrez Gene 89941
HGNC 21169
MIM 613889
UniProt Q8IXI1  
 RHOT2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for RHOT2
Molecular Function
    GTPase activity GO:0003924 IBA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IBA
Biological Process
    mitochondrion organization GO:0007005 IBA
    cellular homeostasis GO:0019725 IMP
    mitochondrion transport along microtubule GO:0047497 IBA
    mitochondrion transport along microtubule GO:0047497 IMP
    mitochondrial outer membrane permeabilization GO:0097345 IMP
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial outer membrane GO:0005741 IBA
    mitochondrial outer membrane GO:0005741 IDA
    mitochondrial outer membrane GO:0005741 TAS
    membrane GO:0016020 HDA
 Experiment description of studies that identified RHOT2 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for RHOT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Proximity Label-MS Homo sapiens
2 KIF16B 55614
Proximity Label-MS Homo sapiens
3 AFG3L2 10939
Proximity Label-MS Homo sapiens
4 RANBP6 26953
Proximity Label-MS Homo sapiens
5 C1orf198 84886
Proximity Label-MS Homo sapiens
6 SECISBP2  
Proximity Label-MS Homo sapiens
7 ANKLE2 23141
Proximity Label-MS Homo sapiens
8 SPRTN  
Affinity Capture-MS Homo sapiens
9 MTCH1 23787
Proximity Label-MS Homo sapiens
10 PROSER1  
Proximity Label-MS Homo sapiens
11 CENPE 1062
Proximity Label-MS Homo sapiens
12 NDUFS1 4719
Co-fractionation Homo sapiens
13 FBXL4 26235
Proximity Label-MS Homo sapiens
14 KLK5 25818
Affinity Capture-MS Homo sapiens
15 ALMS1  
Proximity Label-MS Homo sapiens
16 JPH1 56704
Proximity Label-MS Homo sapiens
17 MARCH2  
Proximity Label-MS Homo sapiens
18 ARFGAP3 26286
Proximity Label-MS Homo sapiens
19 CISD1 55847
Proximity Label-MS Homo sapiens
20 KIF20A 10112
Affinity Capture-MS Homo sapiens
21 UBC 7316
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 BNIP3L  
Proximity Label-MS Homo sapiens
23 VPS13C 54832
Proximity Label-MS Homo sapiens
24 GRAMD1A  
Proximity Label-MS Homo sapiens
25 HNRNPR 10236
Co-fractionation Homo sapiens
26 PTPN1 5770
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
27 APBB1  
Proximity Label-MS Homo sapiens
28 TAF1  
Affinity Capture-MS Homo sapiens
29 FFAR1  
Affinity Capture-MS Homo sapiens
30 TACC2 10579
Proximity Label-MS Homo sapiens
31 KIAA1671  
Proximity Label-MS Homo sapiens
32 SMIM12  
Proximity Label-MS Homo sapiens
33 APEX1 328
Affinity Capture-RNA Homo sapiens
34 KIAA1429 25962
Affinity Capture-MS Homo sapiens
35 TIMMDC1  
Proximity Label-MS Homo sapiens
36 PPTC7 160760
Affinity Capture-MS Homo sapiens
37 VTA1 51534
Proximity Label-MS Homo sapiens
38 FIS1 51024
Proximity Label-MS Homo sapiens
39 MRPL20 55052
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 NDUFS3 4722
Proximity Label-MS Homo sapiens
41 B3GNT2 10678
Affinity Capture-MS Homo sapiens
42 STBD1 8987
Proximity Label-MS Homo sapiens
43 SMCR8 140775
Proximity Label-MS Homo sapiens
44 COQ9  
Affinity Capture-MS Homo sapiens
45 EIF4ENIF1 56478
Proximity Label-MS Homo sapiens
46 DNAJC11 55735
Proximity Label-MS Homo sapiens
47 NAV1 89796
Proximity Label-MS Homo sapiens
48 CHMP5 51510
Proximity Label-MS Homo sapiens
49 SPAG9 9043
Proximity Label-MS Homo sapiens
50 ARMCX4  
Proximity Label-MS Homo sapiens
51 RAB3B 5865
Proximity Label-MS Homo sapiens
52 CENPF 1063
Proximity Label-MS Homo sapiens
53 TRABD 80305
Proximity Label-MS Homo sapiens
54 MARCH1  
Proximity Label-MS Homo sapiens
55 ABCD3 5825
Proximity Label-MS Homo sapiens
56 DDRGK1 65992
Proximity Label-MS Homo sapiens
57 MARCH5  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 CHCHD3 54927
Proximity Label-MS Homo sapiens
59 VPS13D 55187
Proximity Label-MS Homo sapiens
60 NXPH1  
Affinity Capture-MS Homo sapiens
61 LSG1  
Proximity Label-MS Homo sapiens
62 PGRMC2 10424
Proximity Label-MS Homo sapiens
63 EXD2  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
64 FIGNL1 63979
Proximity Label-MS Homo sapiens
65 SUN1 23353
Proximity Label-MS Homo sapiens
66 SLC25A46 91137
Proximity Label-MS Homo sapiens
67 WDFY3 23001
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 RHOT1 55288
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 F2RL1  
Affinity Capture-MS Homo sapiens
70 BTAF1 9044
Affinity Capture-MS Homo sapiens
71 ZC3HAV1 56829
Proximity Label-MS Homo sapiens
72 MAVS 57506
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
73 HSD17B4 3295
Proximity Label-MS Homo sapiens
74 FAM73A  
Proximity Label-MS Homo sapiens
75 ESYT2 57488
Proximity Label-MS Homo sapiens
76 FAF2 23197
Proximity Label-MS Homo sapiens
77 ZFYVE9  
Two-hybrid Homo sapiens
78 RAVER1 125950
Proximity Label-MS Homo sapiens
79 ATP6AP1 537
Proximity Label-MS Homo sapiens
80 ARMCX3 51566
Proximity Label-MS Homo sapiens
81 VIPAS39 63894
Proximity Label-MS Homo sapiens
82 KIF14 9928
Affinity Capture-MS Homo sapiens
83 EXOC4 60412
Proximity Label-MS Homo sapiens
84 EMC1 23065
Proximity Label-MS Homo sapiens
85 CAMLG 819
Proximity Label-MS Homo sapiens
86 BUB1  
Proximity Label-MS Homo sapiens
87 PALD1 27143
Proximity Label-MS Homo sapiens
88 DDX19B 11269
Affinity Capture-MS Homo sapiens
89 PXMP2  
Proximity Label-MS Homo sapiens
90 CHMP4C 92421
Affinity Capture-MS Homo sapiens
91 EFNA2  
Affinity Capture-MS Homo sapiens
92 KIAA1217 56243
Proximity Label-MS Homo sapiens
93 TNRC6C  
Proximity Label-MS Homo sapiens
94 PUS1 80324
Proximity Label-MS Homo sapiens
95 VEZT 55591
Proximity Label-MS Homo sapiens
96 MTCH2 23788
Proximity Label-MS Homo sapiens
97 SCFD1 23256
Proximity Label-MS Homo sapiens
98 TMEM14B  
Two-hybrid Homo sapiens
99 SMPD4 55627
Proximity Label-MS Homo sapiens
100 SAMM50 25813
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
101 RABL3 285282
Proximity Label-MS Homo sapiens
102 RPL9 6133
Co-fractionation Homo sapiens
103 PARK2  
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
104 FUNDC2 65991
Proximity Label-MS Homo sapiens
105 MTFR1L 56181
Proximity Label-MS Homo sapiens
106 C2CD4C  
Proximity Label-MS Homo sapiens
107 ATPAF1  
Proximity Label-MS Homo sapiens
108 ACIN1 22985
Co-fractionation Homo sapiens
109 SNAP47 116841
Proximity Label-MS Homo sapiens
110 DIABLO 56616
Proximity Label-MS Homo sapiens
111 LARP4 113251
Proximity Label-MS Homo sapiens
112 TBC1D32 221322
Proximity Label-MS Homo sapiens
113 NDUFS8 4728
Co-fractionation Homo sapiens
114 RAB13 5872
Proximity Label-MS Homo sapiens
115 SLAIN1 122060
Proximity Label-MS Homo sapiens
116 CLCC1 23155
Proximity Label-MS Homo sapiens
117 MTX3  
Proximity Label-MS Homo sapiens
118 S1PR1 1901
Affinity Capture-MS Homo sapiens
119 NXPH2  
Affinity Capture-MS Homo sapiens
120 BCL2L13 23786
Proximity Label-MS Homo sapiens
121 MLX  
Proximity Label-MS Homo sapiens
122 MIA3 375056
Proximity Label-MS Homo sapiens
123 GK  
Proximity Label-MS Homo sapiens
124 MTDH 92140
Proximity Label-MS Homo sapiens
125 TACC1 6867
Proximity Label-MS Homo sapiens
126 PREB 10113
Proximity Label-MS Homo sapiens
127 DHX9 1660
Co-fractionation Homo sapiens
128 STX5 6811
Proximity Label-MS Homo sapiens
129 TECR 9524
Co-fractionation Homo sapiens
130 ATP6AP2 10159
Proximity Label-MS Homo sapiens
131 ZCCHC11 23318
Proximity Label-MS Homo sapiens
132 CCDC47 57003
Proximity Label-MS Homo sapiens
133 MFF 56947
Proximity Label-MS Homo sapiens
134 ARMCX2 9823
Proximity Label-MS Homo sapiens
135 SLC33A1 9197
Proximity Label-MS Homo sapiens
136 RMDN3 55177
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
137 SP100 6672
Affinity Capture-MS Homo sapiens
138 FAM188B  
Proximity Label-MS Homo sapiens
139 GOLGA3 2802
Proximity Label-MS Homo sapiens
140 TEX2 55852
Proximity Label-MS Homo sapiens
141 ANLN 54443
Affinity Capture-MS Homo sapiens
142 OXA1L  
Co-fractionation Homo sapiens
143 DST 667
Proximity Label-MS Homo sapiens
144 CCDC115 84317
Proximity Label-MS Homo sapiens
145 NTRK1 4914
Affinity Capture-MS Homo sapiens
146 CYB5B 80777
Proximity Label-MS Homo sapiens
147 FAM83B  
Proximity Label-MS Homo sapiens
148 APLNR  
Affinity Capture-MS Homo sapiens
149 IPO5 3843
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
150 EMC3 55831
Proximity Label-MS Homo sapiens
151 VAPB 9217
Proximity Label-MS Homo sapiens
152 AIFM1 9131
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
153 RPS2 6187
Co-fractionation Homo sapiens
154 EMC8 10328
Proximity Label-MS Homo sapiens
155 RAB5A 5868
Co-fractionation Homo sapiens
156 CDCA3 83461
Proximity Label-MS Homo sapiens
157 ATP2B2 491
Affinity Capture-MS Homo sapiens
158 CDKAL1  
Proximity Label-MS Homo sapiens
159 MTX2 10651
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
160 SARM1 23098
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 TRPM7 54822
Proximity Label-MS Homo sapiens
162 EEF2 1938
Co-fractionation Homo sapiens
163 PRKAR2A 5576
Proximity Label-MS Homo sapiens
164 BRD8 10902
Affinity Capture-MS Homo sapiens
165 MGARP  
Affinity Capture-MS Homo sapiens
166 RAB29 8934
Proximity Label-MS Homo sapiens
167 CUL3 8452
Affinity Capture-MS Homo sapiens
168 NR3C1 2908
Proximity Label-MS Homo sapiens
169 STIM1 6786
Proximity Label-MS Homo sapiens
170 SRSF5 6430
Co-fractionation Homo sapiens
171 SYNE1 23345
Proximity Label-MS Homo sapiens
172 FKBP8 23770
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
173 MYO19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
174 FBXO6 26270
Affinity Capture-MS Homo sapiens
175 MTFR1  
Proximity Label-MS Homo sapiens
176 MTFR2  
Proximity Label-MS Homo sapiens
177 RIPK4  
Affinity Capture-MS Homo sapiens
178 EHBP1 23301
Proximity Label-MS Homo sapiens
179 SASS6 163786
Proximity Label-MS Homo sapiens
180 SGPP1 81537
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
181 OCIAD1 54940
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
182 C17orf80 55028
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
183 SCYL2 55681
Proximity Label-MS Homo sapiens
184 PEX14 5195
Proximity Label-MS Homo sapiens
185 TMEM86B  
Two-hybrid Homo sapiens
186 PRKACA 5566
Proximity Label-MS Homo sapiens
187 UBXN4 23190
Proximity Label-MS Homo sapiens
188 SOAT1 6646
Proximity Label-MS Homo sapiens
189 ACSL3 2181
Proximity Label-MS Homo sapiens
190 AAAS 8086
Proximity Label-MS Homo sapiens
191 CNR2  
Affinity Capture-MS Homo sapiens
192 RPA3 6119
Proximity Label-MS Homo sapiens
193 PEX11B 8799
Proximity Label-MS Homo sapiens
194 EMC2 9694
Proximity Label-MS Homo sapiens
195 GPR45  
Affinity Capture-MS Homo sapiens
196 PEX1 5189
Proximity Label-MS Homo sapiens
197 IMMT 10989
Proximity Label-MS Homo sapiens
198 VRK2 7444
Proximity Label-MS Homo sapiens
199 RPN1 6184
Proximity Label-MS Homo sapiens
200 MFN2 9927
Proximity Label-MS Homo sapiens
201 AHNAK2 113146
Proximity Label-MS Homo sapiens
202 RNF2  
Affinity Capture-MS Homo sapiens
203 CRYBG3  
Proximity Label-MS Homo sapiens
204 ILK 3611
Affinity Capture-MS Homo sapiens
205 HAX1  
Proximity Label-MS Homo sapiens
206 TMEM209 84928
Proximity Label-MS Homo sapiens
207 LEMD3  
Proximity Label-MS Homo sapiens
208 AKAP1 8165
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
209 NUP133 55746
Proximity Label-MS Homo sapiens
210 ACBD5 91452
Proximity Label-MS Homo sapiens
211 VMA21  
Proximity Label-MS Homo sapiens
212 HK2 3099
Proximity Label-MS Homo sapiens
213 TTC17 55761
Proximity Label-MS Homo sapiens
214 TRAK2 66008
Affinity Capture-MS Homo sapiens
215 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
216 PHB2 11331
Proximity Label-MS Homo sapiens
217 ALDH3A2 224
Proximity Label-MS Homo sapiens
218 NUP107 57122
Proximity Label-MS Homo sapiens
219 TRIM13  
Proximity Label-MS Homo sapiens
220 PARP1 142
Proximity Label-MS Homo sapiens
221 WDR41  
Proximity Label-MS Homo sapiens
222 TMEM57  
Proximity Label-MS Homo sapiens
223 TRAK1 22906
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
224 DOCK5 80005
Affinity Capture-MS Homo sapiens
225 MTMR3  
Proximity Label-MS Homo sapiens
226 PEX19 5824
Proximity Label-MS Homo sapiens
227 PDCL 5082
Proximity Label-MS Homo sapiens
228 DNAJA2 10294
Proximity Label-MS Homo sapiens
229 TPTE  
Affinity Capture-MS Homo sapiens