Gene description for IFT140
Gene name intraflagellar transport 140
Gene symbol IFT140
Other names/aliases MZSDS
SRTD9
WDTC2
c305C8.4
c380F5.1
gs114
Species Homo sapiens
 Database cross references - IFT140
ExoCarta ExoCarta_9742
Entrez Gene 9742
HGNC 29077
MIM 614620
UniProt Q96RY7  
 IFT140 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for IFT140
Molecular Function
    molecular_function GO:0003674 ND
Biological Process
    cilium assembly GO:0042384 IBA
    skeletal system morphogenesis GO:0048705 IMP
    protein localization to cilium GO:0061512 IMP
    organelle organization GO:0006996 TAS
    intraciliary retrograde transport GO:0035721 IBA
    regulation of cilium assembly GO:1902017 IMP
    renal system development GO:0072001 IMP
    retina development in camera-type eye GO:0060041 IMP
Subcellular Localization
    ciliary tip GO:0097542 TAS
    centrosome GO:0005813 IDA
    axoneme GO:0005930 ISS
    ciliary basal body GO:0036064 IDA
    photoreceptor connecting cilium GO:0032391 IEA
    primary cilium GO:0072372 TAS
    intraciliary transport particle A GO:0030991 IDA
 Experiment description of studies that identified IFT140 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for IFT140
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which IFT140 is involved
PathwayEvidenceSource
Hedgehog 'off' state TAS Reactome
Intraflagellar transport TAS Reactome





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