Gene description for HPS3
Gene name Hermansky-Pudlak syndrome 3
Gene symbol HPS3
Other names/aliases SUTAL
Species Homo sapiens
 Database cross references - HPS3
ExoCarta ExoCarta_84343
Vesiclepedia VP_84343
Entrez Gene 84343
HGNC 15597
MIM 606118
UniProt Q969F9  
 HPS3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for HPS3
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    organelle organization GO:0006996 IBA
    intracellular transport GO:0046907 NAS
    platelet dense granule organization GO:0060155 NAS
    melanosome assembly GO:1903232 NAS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    early endosome GO:0005769 NAS
    cytosol GO:0005829 IEA
    BLOC-2 complex GO:0031084 IBA
    BLOC-2 complex GO:0031084 IPI
 Experiment description of studies that identified HPS3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HPS3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZNF252P-AS1  
Affinity Capture-MS Homo sapiens
2 ARMC5 79798
Affinity Capture-MS Homo sapiens
3 MAP2K2 5605
Affinity Capture-MS Homo sapiens
4 CIB2  
Affinity Capture-MS Homo sapiens
5 NSUN5P1  
Affinity Capture-MS Homo sapiens
6 SIRT6  
Affinity Capture-MS Homo sapiens
7 PPM1M  
Affinity Capture-MS Homo sapiens
8 PSMD14 10213
Affinity Capture-MS Homo sapiens
9 C9orf163  
Affinity Capture-MS Homo sapiens
10 FAM167A  
Affinity Capture-MS Homo sapiens
11 SLC25A48  
Affinity Capture-MS Homo sapiens
12 D2HGDH 728294
Affinity Capture-MS Homo sapiens
13 C2orf27B  
Affinity Capture-MS Homo sapiens
14 SULT1C4  
Affinity Capture-MS Homo sapiens
15 HDHD1  
Affinity Capture-MS Homo sapiens
16 HPS5 11234
Affinity Capture-MS Homo sapiens
17 CHIA  
Affinity Capture-MS Homo sapiens
18 FKBP8 23770
Affinity Capture-MS Homo sapiens
19 TKT 7086
Affinity Capture-MS Homo sapiens
20 LOXL4 84171
Affinity Capture-MS Homo sapiens
21 KLHL34  
Affinity Capture-MS Homo sapiens
22 DUSP16  
Affinity Capture-MS Homo sapiens
23 NXF1 10482
Affinity Capture-RNA Homo sapiens
24 SKAP1 8631
Affinity Capture-MS Homo sapiens
25 FKBP5 2289
Affinity Capture-MS Homo sapiens
26 TCL1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 DHFR 1719
Affinity Capture-MS Homo sapiens
28 TRMU  
Affinity Capture-MS Homo sapiens
29 SOHLH1  
Affinity Capture-MS Homo sapiens
30 MIF4GD 57409
Affinity Capture-MS Homo sapiens
31 RAB7A 7879
Proximity Label-MS Homo sapiens
32 RAB9A 9367
Proximity Label-MS Homo sapiens
33 THBS3 7059
Affinity Capture-MS Homo sapiens
34 F12  
Affinity Capture-MS Homo sapiens
35 B4GALT2  
Affinity Capture-MS Homo sapiens
36 HPS6 79803
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 EFNB2 1948
Affinity Capture-MS Homo sapiens
38 INF2 64423
Affinity Capture-MS Homo sapiens
39 ATG7 10533
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HPS3 is involved
No pathways found





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