Gene description for Tmod3
Gene name tropomodulin 3
Gene symbol Tmod3
Other names/aliases U-Tmod
UTMOD
Species Mus musculus
 Database cross references - Tmod3
ExoCarta ExoCarta_50875
Vesiclepedia VP_50875
Entrez Gene 50875
UniProt Q9JHJ0  
 Tmod3 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Tmod3
Molecular Function
    actin binding GO:0003779 IEA
    tropomyosin binding GO:0005523 IBA
    tropomyosin binding GO:0005523 IDA
    microtubule minus-end binding GO:0051011 ISO
Biological Process
    muscle contraction GO:0006936 IBA
    actin filament organization GO:0007015 IBA
    actin cytoskeleton organization GO:0030036 IMP
    myofibril assembly GO:0030239 IBA
    mitotic cell cycle phase transition GO:0044772 IMP
    erythrocyte development GO:0048821 IMP
    cell motility GO:0048870 ISO
    pointed-end actin filament capping GO:0051694 ISO
    positive regulation of mitotic cell cycle phase transition GO:1901992 IMP
Subcellular Localization
    ruffle GO:0001726 ISO
    cytoskeleton GO:0005856 IBA
    striated muscle thin filament GO:0005865 IBA
    striated muscle thin filament GO:0005865 IDA
    myofibril GO:0030016 IBA
    lamellipodium GO:0030027 ISO
    filamentous actin GO:0031941 ISO
 Experiment description of studies that identified Tmod3 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Tmod3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACTR2 10097
Affinity Capture-MS Homo sapiens
2 ARHGAP21 57584
Affinity Capture-MS Homo sapiens
3 ARPC5L 81873
Affinity Capture-MS Homo sapiens
4 CPM 1368
Affinity Capture-MS Homo sapiens
5 ARPC2 10109
Affinity Capture-MS Homo sapiens
6 ARPC4 10093
Affinity Capture-MS Homo sapiens
7 DBN1 1627
Affinity Capture-MS Homo sapiens
8 STON2 85439
Affinity Capture-MS Homo sapiens
9 ADD3 120
Affinity Capture-MS Homo sapiens
10 MYO5C 55930
Affinity Capture-MS Homo sapiens
11 CFL1 1072
Affinity Capture-MS Homo sapiens
12 CLTB 1212
Affinity Capture-MS Homo sapiens
13 UBXN2A  
Affinity Capture-MS Homo sapiens
14 VASP 7408
Affinity Capture-MS Homo sapiens
15 Myd88  
Affinity Capture-MS Mus musculus
16 Tmem173  
Proximity Label-MS Mus musculus
17 CAPZB 832
Affinity Capture-MS Homo sapiens
18 PPP1R12A 4659
Affinity Capture-MS Homo sapiens
19 ABLIM1 3983
Affinity Capture-MS Homo sapiens
20 TBL1XR1 79718
Affinity Capture-MS Homo sapiens
21 FBXO46  
Affinity Capture-MS Homo sapiens
22 ADD1 118
Affinity Capture-MS Homo sapiens
23 BASP1 10409
Affinity Capture-MS Homo sapiens
24 PHLDB2 90102
Affinity Capture-MS Homo sapiens
25 CEP162  
Affinity Capture-MS Homo sapiens
26 MYO1B 4430
Affinity Capture-MS Homo sapiens
27 Eed  
Affinity Capture-MS Mus musculus
28 PALM 5064
Affinity Capture-MS Homo sapiens
29 TWF1 5756
Affinity Capture-MS Homo sapiens
30 CYBRD1 79901
Affinity Capture-MS Homo sapiens
31 WDR1 9948
Affinity Capture-MS Homo sapiens
32 COBL  
Affinity Capture-MS Homo sapiens
33 CAPZA1 829
Affinity Capture-MS Homo sapiens
34 SORBS2  
Affinity Capture-MS Homo sapiens
35 LUZP1 7798
Affinity Capture-MS Homo sapiens
36 RAI14 26064
Affinity Capture-MS Homo sapiens
37 RALA 5898
Affinity Capture-MS Homo sapiens
38 RRAS2 22800
Affinity Capture-MS Homo sapiens
39 LRRFIP2 9209
Affinity Capture-MS Homo sapiens
40 DDX10  
Affinity Capture-MS Homo sapiens
41 CHMP4B 128866
Affinity Capture-MS Homo sapiens
42 LRRFIP1 9208
Affinity Capture-MS Homo sapiens
43 ACTN4 81
Affinity Capture-MS Homo sapiens
44 HACE1 57531
Affinity Capture-MS Homo sapiens
45 ACTB 60
Affinity Capture-MS Homo sapiens
46 FLOT2 2319
Affinity Capture-MS Homo sapiens
47 ACTG1 71
Affinity Capture-MS Homo sapiens
48 LIMA1 51474
Affinity Capture-MS Homo sapiens
49 ARPC1B 10095
Affinity Capture-MS Homo sapiens
50 ARPC3 10094
Affinity Capture-MS Homo sapiens
51 SPECC1 92521
Affinity Capture-MS Homo sapiens
52 MYO5A 4644
Affinity Capture-MS Homo sapiens
53 MYO19  
Affinity Capture-MS Homo sapiens
54 PACSIN3 29763
Affinity Capture-MS Homo sapiens
55 CD59 966
Affinity Capture-MS Homo sapiens
56 Mecp2  
Affinity Capture-MS Mus musculus
57 CORO1C 23603
Affinity Capture-MS Homo sapiens
58 CALM1 801
Affinity Capture-MS Homo sapiens
59 SPTBN1 6711
Affinity Capture-MS Homo sapiens
60 CDC42 998
Affinity Capture-MS Homo sapiens
61 TPM1 7168
Affinity Capture-MS Homo sapiens
62 SYNPO 11346
Affinity Capture-MS Homo sapiens
63 MYO6 4646
Affinity Capture-MS Homo sapiens
64 GNB2 2783
Affinity Capture-MS Homo sapiens
65 FLII 2314
Affinity Capture-MS Homo sapiens
66 AKAP2 11217
Affinity Capture-MS Homo sapiens
67 CLTC 1213
Affinity Capture-MS Homo sapiens
68 MPRIP 23164
Affinity Capture-MS Homo sapiens
69 PLEKHG3 26030
Affinity Capture-MS Homo sapiens
70 GAS2L3  
Affinity Capture-MS Homo sapiens
71 FLOT1 10211
Affinity Capture-MS Homo sapiens
72 Fancd2  
Affinity Capture-MS Mus musculus
73 GSN 2934
Affinity Capture-MS Homo sapiens
74 GNAO1 2775
Affinity Capture-MS Homo sapiens
75 JUP 3728
Affinity Capture-MS Homo sapiens
76 MYO1C 4641
Affinity Capture-MS Homo sapiens
77 ARV1  
Affinity Capture-MS Homo sapiens
78 NEXN 91624
Affinity Capture-MS Homo sapiens
79 SPTAN1 6709
Affinity Capture-MS Homo sapiens
80 DAB2 1601
Affinity Capture-MS Homo sapiens
81 SVIL 6840
Affinity Capture-MS Homo sapiens
82 AP2M1 1173
Affinity Capture-MS Homo sapiens
83 DENND1A 57706
Affinity Capture-MS Homo sapiens
84 MTERF1  
Affinity Capture-MS Homo sapiens
85 Kctd13  
Affinity Capture-MS Mus musculus
86 CAPZA2 830
Affinity Capture-MS Homo sapiens
87 AFAP1 60312
Affinity Capture-MS Homo sapiens
88 INF2 64423
Affinity Capture-MS Homo sapiens
89 CORO2A  
Affinity Capture-MS Homo sapiens
90 FLNA 2316
Affinity Capture-MS Homo sapiens
91 CLTA 1211
Affinity Capture-MS Homo sapiens
92 MYO1E 4643
Affinity Capture-MS Homo sapiens
93 CD44 960
Affinity Capture-MS Homo sapiens
94 SSH2  
Affinity Capture-MS Homo sapiens
95 DSG2 1829
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here