Gene description for ESRP2
Gene name epithelial splicing regulatory protein 2
Gene symbol ESRP2
Other names/aliases RBM35B
Species Homo sapiens
 Database cross references - ESRP2
ExoCarta ExoCarta_80004
Vesiclepedia VP_80004
Entrez Gene 80004
HGNC 26152
MIM 612960
UniProt Q9H6T0  
 ESRP2 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for ESRP2
Molecular Function
    RNA binding GO:0003723 HDA
    mRNA binding GO:0003729 IBA
    mRNA binding GO:0003729 IDA
    protein binding GO:0005515 IPI
Biological Process
    alternative mRNA splicing, via spliceosome GO:0000380 IEA
    regulation of RNA splicing GO:0043484 IBA
    regulation of RNA splicing GO:0043484 IDA
    epithelial cell proliferation GO:0050673 IEA
    positive regulation of epithelial cell proliferation GO:0050679 IEA
    epithelial tube branching involved in lung morphogenesis GO:0060441 IEA
    branching involved in salivary gland morphogenesis GO:0060445 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    ribonucleoprotein complex GO:1990904 IBA
 Experiment description of studies that identified ESRP2 in exosomes
1
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ESRP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 REC8  
Affinity Capture-MS Homo sapiens
2 PSG11  
Affinity Capture-MS Homo sapiens
3 FOXF2  
Affinity Capture-MS Homo sapiens
4 VPS16 64601
Affinity Capture-MS Homo sapiens
5 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
6 DECR2 26063
Affinity Capture-MS Homo sapiens
7 NPAS1  
Affinity Capture-MS Homo sapiens
8 FOXP3  
Affinity Capture-MS Homo sapiens
9 CUL3 8452
Affinity Capture-MS Homo sapiens
10 HSPA8 3312
Affinity Capture-MS Homo sapiens
11 RHOH  
Affinity Capture-MS Homo sapiens
12 BAG2 9532
Affinity Capture-MS Homo sapiens
13 MFSD4  
Affinity Capture-MS Homo sapiens
14 ANKK1  
Affinity Capture-MS Homo sapiens
15 HSPBP1 23640
Affinity Capture-MS Homo sapiens
16 RPA2 6118
Affinity Capture-MS Homo sapiens
17 RPA1 6117
Affinity Capture-MS Homo sapiens
18 NUMBL 9253
Two-hybrid Homo sapiens
19 SULT1C4  
Affinity Capture-MS Homo sapiens
20 ZNF252P-AS1  
Affinity Capture-MS Homo sapiens
21 MGARP  
Affinity Capture-MS Homo sapiens
22 INF2 64423
Affinity Capture-MS Homo sapiens
23 APBA3  
Affinity Capture-MS Homo sapiens
24 PLBD1 79887
Affinity Capture-MS Homo sapiens
25 RBFOX2 23543
Affinity Capture-MS Homo sapiens
26 IL12RB1  
Affinity Capture-MS Homo sapiens
27 FUS 2521
Co-fractionation Homo sapiens
28 B4GALT2  
Affinity Capture-MS Homo sapiens
29 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
30 TRMU  
Affinity Capture-MS Homo sapiens
31 Ppp6r1  
Affinity Capture-MS Mus musculus
32 ALG1L  
Affinity Capture-MS Homo sapiens
33 CRYBB3  
Affinity Capture-MS Homo sapiens
34 MBNL1 4154
Affinity Capture-MS Homo sapiens
35 CLEC11A 6320
Affinity Capture-MS Homo sapiens
36 C12orf74  
Affinity Capture-MS Homo sapiens
37 TUBA1B 10376
Affinity Capture-MS Homo sapiens
38 COMMD5 28991
Affinity Capture-MS Homo sapiens
39 LRRC29  
Affinity Capture-MS Homo sapiens
40 TUBB 203068
Affinity Capture-MS Homo sapiens
41 HNRNPLL 92906
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 D2HGDH 728294
Affinity Capture-MS Homo sapiens
43 RFXANK  
Affinity Capture-MS Homo sapiens
44 RNF111 54778
Affinity Capture-Western Homo sapiens
45 DTX2 113878
Proximity Label-MS Homo sapiens
46 HES6  
Affinity Capture-MS Homo sapiens
47 F12  
Affinity Capture-MS Homo sapiens
48 CDK20  
Affinity Capture-MS Homo sapiens
49 TSHR 7253
Affinity Capture-MS Homo sapiens
50 C9orf163  
Affinity Capture-MS Homo sapiens
51 RPA3 6119
Affinity Capture-MS Homo sapiens
52 MAPK15  
Affinity Capture-MS Homo sapiens
53 HSPB8 26353
Affinity Capture-MS Homo sapiens
54 GALNT9  
Affinity Capture-MS Homo sapiens
55 ATG7 10533
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here