Gene description for SPG11
Gene name spastic paraplegia 11 (autosomal recessive)
Gene symbol SPG11
Other names/aliases KIAA1840
Species Homo sapiens
 Database cross references - SPG11
ExoCarta ExoCarta_80208
Vesiclepedia VP_80208
Entrez Gene 80208
HGNC 11226
MIM 610844
UniProt Q96JI7  
 SPG11 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for SPG11
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IDA
Biological Process
    protein import into nucleus GO:0006606 IEA
    lysosome organization GO:0007040 IDA
    chemical synaptic transmission GO:0007268 IBA
    chemical synaptic transmission GO:0007268 IMP
    axonogenesis GO:0007409 IBA
    neuromuscular junction development GO:0007528 IEA
    memory GO:0007613 IEA
    axo-dendritic transport GO:0008088 IBA
    axo-dendritic transport GO:0008088 IMP
    corticospinal tract morphogenesis GO:0021957 IEA
    protein catabolic process GO:0030163 IEA
    cholesterol efflux GO:0033344 IEA
    vesicle transport along microtubule GO:0047496 IEA
    synaptic vesicle transport GO:0048489 IBA
    synaptic vesicle transport GO:0048489 IMP
    axon extension GO:0048675 IEA
    skeletal muscle fiber development GO:0048741 IEA
    localization within membrane GO:0051668 IEA
    motor behavior GO:0061744 IEA
    phagosome-lysosome fusion involved in apoptotic cell clearance GO:0090389 IEA
    walking behavior GO:0090659 IEA
    motor neuron apoptotic process GO:0097049 IEA
    autophagosome organization GO:1905037 IDA
    regulation of store-operated calcium entry GO:2001256 IEA
Subcellular Localization
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    lysosomal membrane GO:0005765 HDA
    endoplasmic reticulum GO:0005783 IEA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 ISS
    plasma membrane GO:0005886 IDA
    axon GO:0030424 IBA
    dendrite GO:0030425 IBA
    cytoplasmic vesicle GO:0031410 IDA
    synapse GO:0045202 IBA
    synapse GO:0045202 IDA
 Experiment description of studies that identified SPG11 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SPG11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DNAJC7 7266
Proximity Label-MS Homo sapiens
2 TUSC2  
Affinity Capture-MS Homo sapiens
3 DHFR 1719
Affinity Capture-MS Homo sapiens
4 FASN 2194
Positive Genetic Homo sapiens
5 VIPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 NPAS1  
Affinity Capture-MS Homo sapiens
7 LINC01587  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 PRKY  
Affinity Capture-MS Homo sapiens
9 CXCR4 7852
Affinity Capture-MS Homo sapiens
10 GPR17 2840
Affinity Capture-MS Homo sapiens
11 ZHX1-C8orf76  
Affinity Capture-MS Homo sapiens
12 METTL10  
Affinity Capture-MS Homo sapiens
13 BAG2 9532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 HCST  
Affinity Capture-MS Homo sapiens
15 SPRYD4 283377
Affinity Capture-MS Homo sapiens
16 NCKAP1 10787
Affinity Capture-MS Homo sapiens
17 D2HGDH 728294
Affinity Capture-MS Homo sapiens
18 NPTN 27020
Affinity Capture-MS Homo sapiens
19 CRYL1 51084
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 AP5S1  
Affinity Capture-MS Homo sapiens
21 AP5Z1 9907
Affinity Capture-MS Homo sapiens
22 AP5B1 91056
Affinity Capture-MS Homo sapiens
23 FPR1  
Affinity Capture-MS Homo sapiens
24 LAMP2 3920
Proximity Label-MS Homo sapiens
25 WASF2 10163
Affinity Capture-MS Homo sapiens
26 HSP90AA1 3320
Cross-Linking-MS (XL-MS) Homo sapiens
27 METTL21B  
Affinity Capture-MS Homo sapiens
28 C12orf74  
Affinity Capture-MS Homo sapiens
29 DUSP16  
Affinity Capture-MS Homo sapiens
30 SNX6 58533
Affinity Capture-MS Homo sapiens
31 BRK1 55845
Affinity Capture-MS Homo sapiens
32 LAMTOR1 55004
Proximity Label-MS Homo sapiens
33 ABI2 10152
Affinity Capture-MS Homo sapiens
34 FIS1 51024
Affinity Capture-MS Homo sapiens
35 MYC  
Affinity Capture-MS Homo sapiens
36 INF2 64423
Affinity Capture-MS Homo sapiens
37 Elavl1 15568
Affinity Capture-MS Mus musculus
38 GPR45  
Affinity Capture-MS Homo sapiens
39 RAB7A 7879
Proximity Label-MS Homo sapiens
40 RAB9A 9367
Proximity Label-MS Homo sapiens
41 GPR182  
Affinity Capture-MS Homo sapiens
42 DCAF10  
Affinity Capture-MS Homo sapiens
43 PRC1 9055
Affinity Capture-MS Homo sapiens
44 ABI1 10006
Affinity Capture-MS Homo sapiens
45 CYFIP2 26999
Affinity Capture-MS Homo sapiens
46 VCPIP1 80124
Affinity Capture-MS Homo sapiens
47 BBS2 583
Affinity Capture-MS Homo sapiens
48 PCYT1A 5130
Affinity Capture-MS Homo sapiens
49 AP5M1 55745
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 SERTAD3  
Two-hybrid Homo sapiens
51 HYPM  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SPG11 is involved
No pathways found





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