Gene description for Uso1
Gene name USO1 vesicle docking factor
Gene symbol Uso1
Other names/aliases 115kDa
TAP
Vdp
Species Mus musculus
 Database cross references - Uso1
ExoCarta ExoCarta_56041
Entrez Gene 56041
UniProt Q9Z1Z0  
 Uso1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Uso1
Molecular Function
    protein transporter activity GO:0008565 IDA
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 ISO
Biological Process
    vesicle-mediated transport GO:0016192 IEA
    vesicle fusion with Golgi apparatus GO:0048280 IEA
    intracellular protein transport GO:0006886 IDA
    Golgi vesicle docking GO:0048211 IBA
    transcytosis GO:0045056 ISO
    membrane fusion GO:0061025 ISO
    ER to Golgi vesicle-mediated transport GO:0006888 IBA
    protein transport GO:0015031 IEA
    transport GO:0006810 IEA
    Golgi vesicle transport GO:0048193 IEA
Subcellular Localization
    ER to Golgi transport vesicle membrane GO:0012507 IBA
    Golgi membrane GO:0000139 IEA
    Golgi stack GO:0005795 IBA
    nucleolus GO:0005730 ISO
    cytosol GO:0005829 IDA
    cytoplasm GO:0005737 IEA
    Golgi apparatus GO:0005794 ISO
    perinuclear region of cytoplasm GO:0048471 IDA
    membrane GO:0016020 ISO
    endoplasmic reticulum GO:0005783 IBA
 Experiment description of studies that identified Uso1 in exosomes
1
Experiment ID 210
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Uso1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Uso1 is involved
PathwayEvidenceSource
Golgi Cisternae Pericentriolar Stack Reorganization IEA Reactome





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