Gene description for TBC1D2B
Gene name TBC1 domain family, member 2B
Gene symbol TBC1D2B
Other names/aliases -
Species Homo sapiens
 Database cross references - TBC1D2B
ExoCarta ExoCarta_23102
Vesiclepedia VP_23102
Entrez Gene 23102
HGNC 29183
UniProt Q9UPU7  
 TBC1D2B identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TBC1D2B
Molecular Function
    GTPase activator activity GO:0005096 IBA
    protein binding GO:0005515 IPI
Biological Process
    endocytosis GO:0006897 IMP
    regulation of cilium assembly GO:1902017 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    early endosome GO:0005769 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified TBC1D2B in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TBC1D2B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TFR2 7036
Affinity Capture-MS Homo sapiens
2 GABARAPL1 23710
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
3 TRDMT1  
Two-hybrid Homo sapiens
4 RAB35 11021
Proximity Label-MS Homo sapiens
5 NPAS1  
Affinity Capture-MS Homo sapiens
6 WHAMMP3  
Affinity Capture-MS Homo sapiens
7 SYNPO2L  
Affinity Capture-MS Homo sapiens
8 KIF14 9928
Affinity Capture-MS Homo sapiens
9 D2HGDH 728294
Affinity Capture-MS Homo sapiens
10 PSMC3 5702
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 CIB2  
Affinity Capture-MS Homo sapiens
12 LAMTOR1 55004
Proximity Label-MS Homo sapiens
13 METTL10  
Affinity Capture-MS Homo sapiens
14 XPO1 7514
Affinity Capture-MS Homo sapiens
15 GJA1 2697
Proximity Label-MS Homo sapiens
16 ECT2 1894
Affinity Capture-MS Homo sapiens
17 EVI5  
Affinity Capture-MS Homo sapiens
18 CAV3 859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 PFN1 5216
Proximity Label-MS Homo sapiens
20 KRT8 3856
Proximity Label-MS Homo sapiens
21 S100A6 6277
Affinity Capture-MS Homo sapiens
22 FAM96A  
Affinity Capture-MS Homo sapiens
23 RAD51B  
Affinity Capture-MS Homo sapiens
24 ASB6 140459
Affinity Capture-MS Homo sapiens
25 SNX16  
Affinity Capture-MS Homo sapiens
26 CCT8L2  
Affinity Capture-MS Homo sapiens
27 LOXL2 4017
Affinity Capture-MS Homo sapiens
28 NRSN1  
Affinity Capture-MS Homo sapiens
29 SULT1C4  
Affinity Capture-MS Homo sapiens
30 METTL21B  
Affinity Capture-MS Homo sapiens
31 KLHL40  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 PPP4R1L  
Affinity Capture-MS Homo sapiens
33 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
34 BRK1 55845
Affinity Capture-MS Homo sapiens
35 PRPS2 5634
Affinity Capture-MS Homo sapiens
36 RAB4A 5867
Proximity Label-MS Homo sapiens
37 AURKB 9212
Affinity Capture-MS Homo sapiens
38 GSTM3 2947
Affinity Capture-MS Homo sapiens
39 C6orf141  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 MAP1LC3A 84557
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
41 PTCD3 55037
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 COG6 57511
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 TRIM37  
Proximity Label-MS Homo sapiens
44 DHFR 1719
Affinity Capture-MS Homo sapiens
45 INF2 64423
Affinity Capture-MS Homo sapiens
46 SOHLH1  
Affinity Capture-MS Homo sapiens
47 NT5C 30833
Affinity Capture-MS Homo sapiens
48 APBB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 RAB11A 8766
Proximity Label-MS Homo sapiens
50 RFXANK  
Affinity Capture-MS Homo sapiens
51 NAA11 84779
Affinity Capture-MS Homo sapiens
52 THBS3 7059
Affinity Capture-MS Homo sapiens
53 PRKY  
Affinity Capture-MS Homo sapiens
54 RHOB 388
Proximity Label-MS Homo sapiens
55 CCDC53 51019
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 CCDC96  
Affinity Capture-MS Homo sapiens
57 PPM1M  
Affinity Capture-MS Homo sapiens
58 PAK7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 SNTB2 6645
Affinity Capture-MS Homo sapiens
60 CEP120  
Affinity Capture-MS Homo sapiens
61 ALOX5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 LURAP1  
Affinity Capture-MS Homo sapiens
63 HSPB8 26353
Affinity Capture-MS Homo sapiens
64 UBXN6 80700
Affinity Capture-MS Homo sapiens
65 RAB5A 5868
Proximity Label-MS Homo sapiens
66 CRYBB3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TBC1D2B is involved
No pathways found





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