Gene description for RND3
Gene name Rho family GTPase 3
Gene symbol RND3
Other names/aliases ARHE
Species Homo sapiens
 Database cross references - RND3
ExoCarta ExoCarta_390
Entrez Gene 390
HGNC 671
MIM 602924
UniProt P61587  
 RND3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for RND3
Molecular Function
    GTPase activity GO:0003924 TAS
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IEA
Biological Process
    cell adhesion GO:0007155 TAS
    actin cytoskeleton organization GO:0030036 TAS
    small GTPase mediated signal transduction GO:0007264 IEA
    metabolic process GO:0008152 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    Golgi membrane GO:0000139 IEA
    focal adhesion GO:0005925 IDA
 Experiment description of studies that identified RND3 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for RND3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SFN 2810
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
3 SOC  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
4 PLXNB1 5364
Reconstituted Complex Homo sapiens
5 ROCK1 6093
Reconstituted Complex Homo sapiens
6 CIT 11113
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which RND3 is involved
No pathways found

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