Gene description for FANCC
Gene name Fanconi anemia, complementation group C
Gene symbol FANCC
Other names/aliases FA3
FAC
FACC
Species Homo sapiens
 Database cross references - FANCC
ExoCarta ExoCarta_2176
Entrez Gene 2176
HGNC 3584
MIM 613899
UniProt Q00597  
 FANCC identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for FANCC
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    removal of superoxide radicals GO:0019430 IEA
    myeloid cell homeostasis GO:0002262 IEA
    protein complex assembly GO:0006461 TAS
    DNA repair GO:0006281 TAS
    germ cell development GO:0007281 IEA
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP
    nucleotide-excision repair GO:0006289 IEA
Subcellular Localization
    Fanconi anaemia nuclear complex GO:0043240 IDA
    cytoplasm GO:0005737 TAS
    cytosol GO:0005829 IDA
    nucleoplasm GO:0005654 TAS
    nucleus GO:0005634 TAS
 Experiment description of studies that identified FANCC in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for FANCC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GSTP1 2950
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
2 TZFP  
Two-hybrid Homo sapiens
3 ATP6  
Two-hybrid Homo sapiens
4 SPTAN1 6709
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
5 FANCG  
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
6 KRT1 3848
Two-hybrid Homo sapiens
7 RPS3A 6189
Two-hybrid Homo sapiens
8 HSPA8 3312
Two-hybrid Homo sapiens
9 IK  
Two-hybrid Homo sapiens
10 EIF2AK2 5610
Affinity Capture-Western Homo sapiens
11 TCERG1  
Two-hybrid Homo sapiens
12 FLJ10213  
Affinity Capture-MS Homo sapiens
13 SPTA1  
Invivo Homo sapiens
14 USP14 9097
Two-hybrid Homo sapiens
15 HSP90AA1 3320
Two-hybrid Homo sapiens
16 AZIN1 51582
Two-hybrid Homo sapiens
17 HSP90B1 7184
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
18 CDK1 983
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
19 FANCE  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
20 FANCA  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
21 STAT1 6772
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
22 ZBTB32  
Affinity Capture-Western Homo sapiens
23 FANCF  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
24 HSPA1A 3303
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
25 RPL18 6141
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which FANCC is involved
PathwayEvidenceSource
Fanconi Anemia pathway TAS Reactome





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