Gene description for HGF
Gene name hepatocyte growth factor (hepapoietin A; scatter factor)
Gene symbol HGF
Other names/aliases DFNB39
Species Homo sapiens
 Database cross references - HGF
ExoCarta ExoCarta_3082
Entrez Gene 3082
HGNC 4893
MIM 142409
UniProt P14210  
 HGF identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for HGF
Molecular Function
    serine-type endopeptidase activity GO:0004252 NAS
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 NAS
    identical protein binding GO:0042802 IPI
    chemoattractant activity GO:0042056 IDA
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    mitotic nuclear division GO:0007067 NAS
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    proteolysis GO:0006508 NAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 NAS
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 IEA
    blood coagulation GO:0007596 TAS
    positive chemotaxis GO:0050918 IDA
    hyaluronan metabolic process GO:0030212 IEA
    negative regulation of release of cytochrome c from mitochondria GO:0090201 IDA
    positive regulation of osteoblast differentiation GO:0045669 NAS
    epithelial to mesenchymal transition GO:0001837 TAS
    regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665 IDA
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IDA
    positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IDA
    positive regulation of DNA biosynthetic process GO:2000573 IDA
    positive regulation of neuron projection regeneration GO:0070572 IEA
    positive regulation of myelination GO:0031643 IEA
    organ regeneration GO:0031100 IEA
    liver development GO:0001889 IEA
    platelet degranulation GO:0002576 TAS
    platelet activation GO:0030168 TAS
    cellular response to hepatocyte growth factor stimulus GO:0035729 IDA
    myoblast proliferation GO:0051450 IEA
    negative regulation of hydrogen peroxide-mediated programmed cell death GO:1901299 IDA
    cell chemotaxis GO:0060326 IDA
    hepatocyte growth factor receptor signaling pathway GO:0048012 IDA
    positive regulation of angiogenesis GO:0045766 IEA
    activation of MAPK activity GO:0000187 IEA
    positive regulation of cell migration GO:0030335 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    membrane GO:0016020 IDA
    platelet alpha granule lumen GO:0031093 TAS
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified HGF in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for HGF
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SDC2 6383
Reconstituted Complex Homo sapiens
2 MET 4233
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Invivo Homo sapiens
3 HGF 3082
Invitro Homo sapiens
Invitro Homo sapiens
4 CLEC3B 7123
Reconstituted Complex Homo sapiens
5 HGFAC 3083
Invitro Homo sapiens
6 SDC1 6382
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which HGF is involved
Interleukin-7 signaling TAS Reactome
Platelet degranulation TAS Reactome

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