Gene description for ARMC8
Gene name armadillo repeat containing 8
Gene symbol ARMC8
Other names/aliases GID5
HSPC056
S863-2
VID28
Species Homo sapiens
 Database cross references - ARMC8
ExoCarta ExoCarta_25852
Vesiclepedia VP_25852
Entrez Gene 25852
HGNC 24999
UniProt Q8IUR7  
 ARMC8 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for ARMC8
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
Subcellular Localization
    ubiquitin ligase complex GO:0000151 IDA
    extracellular region GO:0005576 TAS
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    GID complex GO:0034657 IBA
    specific granule lumen GO:0035580 TAS
    intracellular membrane-bounded organelle GO:0043231 IDA
    tertiary granule lumen GO:1904724 TAS
 Experiment description of studies that identified ARMC8 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ARMC8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SFRP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 ZMYND19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 BCKDK 10295
Affinity Capture-MS Homo sapiens
5 MRPL17  
Affinity Capture-MS Homo sapiens
6 SKI 6497
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 PTX3 5806
Affinity Capture-MS Homo sapiens
8 RPA2 6118
Proximity Label-MS Homo sapiens
9 PRG3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 NFATC1 4772
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 MTG2  
Affinity Capture-MS Homo sapiens
12 GID4  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
13 CDK5RAP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 LAD1 3898
Affinity Capture-MS Homo sapiens
15 HBP1  
Affinity Capture-MS Homo sapiens
16 CFL1 1072
Cross-Linking-MS (XL-MS) Homo sapiens
17 SLURP1  
Affinity Capture-MS Homo sapiens
18 WDR26 80232
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
19 WBP5  
Affinity Capture-MS Homo sapiens
20 KIAA1429 25962
Affinity Capture-MS Homo sapiens
21 TRIM28 10155
Affinity Capture-MS Homo sapiens
22 ACSM3  
Affinity Capture-MS Homo sapiens
23 TCF12  
Two-hybrid Homo sapiens
24 RANBP10 57610
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 LECT2  
Affinity Capture-MS Homo sapiens
26 HGS 9146
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
27 CIB3  
Two-hybrid Homo sapiens
28 MRPS23 51649
Affinity Capture-MS Homo sapiens
29 MRPS24 64951
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 GCG  
Affinity Capture-MS Homo sapiens
31 MPP2 4355
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 FTSJ2 29960
Affinity Capture-MS Homo sapiens
33 MKLN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 GSPT1 2935
Affinity Capture-MS Homo sapiens
35 STX6 10228
Two-hybrid Homo sapiens
36 MRPL39 54148
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PTPN14 5784
Affinity Capture-MS Homo sapiens
38 GDF15 9518
Affinity Capture-MS Homo sapiens
39 ADCYAP1  
Affinity Capture-MS Homo sapiens
40 ARHGAP22 58504
Affinity Capture-MS Homo sapiens
41 MRPL4 51073
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 VWA8 23078
Affinity Capture-MS Homo sapiens
43 KCTD6  
Affinity Capture-MS Homo sapiens
44 C15orf59  
Affinity Capture-MS Homo sapiens
45 MRPS30 10884
Affinity Capture-MS Homo sapiens
46 DDX21 9188
Affinity Capture-MS Homo sapiens
47 NCKIPSD 51517
Affinity Capture-MS Homo sapiens
48 PKP2 5318
Two-hybrid Homo sapiens
49 YPEL5 51646
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 CHRDL2 25884
Affinity Capture-MS Homo sapiens
51 NKAP 79576
Affinity Capture-MS Homo sapiens
52 DIABLO 56616
Affinity Capture-MS Homo sapiens
53 Ypel5  
Affinity Capture-MS Mus musculus
54 PTPN21 11099
Affinity Capture-MS Homo sapiens
55 GID8 54994
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
56 DDX5 1655
Affinity Capture-MS Homo sapiens
57 TIGD5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 PIGT 51604
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 CTNNB1 1499
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
60 LYPD1  
Affinity Capture-MS Homo sapiens
61 TDGF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 WNT10A  
Affinity Capture-MS Homo sapiens
63 ADAMTS1 9510
Affinity Capture-MS Homo sapiens
64 INSL6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 LCA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 RMND5A 64795
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
67 EBI3 10148
Affinity Capture-MS Homo sapiens
68 GPS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 LY6H  
Affinity Capture-MS Homo sapiens
70 PRKCZ 5590
Affinity Capture-MS Homo sapiens
71 HLA-DPB1 3115
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 MMP7 4316
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 CBFA2T3  
Affinity Capture-MS Homo sapiens
74 HTRA2 27429
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
75 EMILIN3  
Affinity Capture-MS Homo sapiens
76 JPH4 84502
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 LILRB4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 IKZF3  
Affinity Capture-MS Homo sapiens
79 CCDC120  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 DEFB110  
Affinity Capture-MS Homo sapiens
81 CST8  
Affinity Capture-MS Homo sapiens
82 PRG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 CUL3 8452
Affinity Capture-MS Homo sapiens
84 RICTOR 253260
Affinity Capture-MS Homo sapiens
85 YLPM1 56252
Affinity Capture-MS Homo sapiens
86 COQ4  
Affinity Capture-MS Homo sapiens
87 SPON1 10418
Affinity Capture-MS Homo sapiens
88 IKZF1  
Affinity Capture-MS Homo sapiens
89 NCKAP5  
Affinity Capture-MS Homo sapiens
90 NATD1  
Affinity Capture-MS Homo sapiens
91 RANBP9 10048
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
92 HAPLN3 145864
Affinity Capture-MS Homo sapiens
93 ANGPTL4 51129
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 CORO2A  
Affinity Capture-MS Homo sapiens
95 FAM83B  
Affinity Capture-MS Homo sapiens
96 LSMEM2  
Affinity Capture-MS Homo sapiens
97 C1QTNF1 114897
Affinity Capture-MS Homo sapiens
98 PKP4 8502
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
99 EGFR 1956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 GNLY  
Affinity Capture-MS Homo sapiens
101 CTNNA1 1495
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
102 BMP1 649
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 MRPL38  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
105 BAIAP2 10458
Affinity Capture-MS Homo sapiens
106 MRPL18 29074
Affinity Capture-MS Homo sapiens
107 MMP13  
Affinity Capture-MS Homo sapiens
108 PKP3 11187
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
109 TNNT1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
110 PRICKLE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 DDX50 79009
Affinity Capture-MS Homo sapiens
112 STYXL1  
Affinity Capture-MS Homo sapiens
113 PLEKHA6 22874
Affinity Capture-MS Homo sapiens
114 RAE1 8480
Affinity Capture-MS Homo sapiens
115 EFHC2  
Affinity Capture-MS Homo sapiens
116 CUTA 51596
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 MRPS2 51116
Affinity Capture-MS Homo sapiens
118 NMB  
Affinity Capture-MS Homo sapiens
119 TLE1 7088
Affinity Capture-MS Homo sapiens
120 RMND5B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 AGMAT  
Affinity Capture-MS Homo sapiens
122 C1orf35  
Affinity Capture-MS Homo sapiens
123 PRMT1 3276
Affinity Capture-MS Homo sapiens
124 PDHB 5162
Affinity Capture-MS Homo sapiens
125 CCDC106  
Affinity Capture-MS Homo sapiens
126 PKP1 5317
Two-hybrid Homo sapiens
127 TLE4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 ANXA13 312
Affinity Capture-MS Homo sapiens
129 RAB8A 4218
Affinity Capture-MS Homo sapiens
130 NEIL1  
Affinity Capture-MS Homo sapiens
131 OSBPL3 26031
Affinity Capture-MS Homo sapiens
132 TCF4  
Affinity Capture-MS Homo sapiens
133 GLIPR1L2  
Affinity Capture-MS Homo sapiens
134 SPINK7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 ZCCHC2 54877
Affinity Capture-MS Homo sapiens
136 GDNF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 CT45A5  
Affinity Capture-MS Homo sapiens
138 TNNT3  
Affinity Capture-MS Homo sapiens
139 NDUFS6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 NOTCH1 4851
Affinity Capture-MS Homo sapiens
141 MAEA 10296
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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