Gene description for CNOT6L
Gene name CCR4-NOT transcription complex, subunit 6-like
Gene symbol CNOT6L
Other names/aliases CCR4b
Species Homo sapiens
 Database cross references - CNOT6L
ExoCarta ExoCarta_246175
Vesiclepedia VP_246175
Entrez Gene 246175
HGNC 18042
UniProt Q96LI5  
 CNOT6L identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CNOT6L
Molecular Function
    3'-5'-RNA exonuclease activity GO:0000175 IBA
    poly(A)-specific ribonuclease activity GO:0004535 TAS
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    nuclear-transcribed mRNA poly(A) tail shortening GO:0000289 NAS
    nuclear-transcribed mRNA poly(A) tail shortening GO:0000289 TAS
    mRNA processing GO:0006397 IEA
    regulation of translation GO:0006417 IEA
    positive regulation of cell population proliferation GO:0008284 IMP
    positive regulation of cytoplasmic mRNA processing body assembly GO:0010606 IMP
    regulatory ncRNA-mediated gene silencing GO:0031047 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    CCR4-NOT complex GO:0030014 IDA
    CCR4-NOT complex GO:0030014 NAS
 Experiment description of studies that identified CNOT6L in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CNOT6L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CNOT7 29883
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
2 MINK1 50488
Affinity Capture-MS Homo sapiens
3 TEX13A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 LZTR1 8216
Two-hybrid Homo sapiens
5 MMP7 4316
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TOB2  
Affinity Capture-MS Homo sapiens
7 RAVER1 125950
Affinity Capture-MS Homo sapiens
8 ZFP36  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 CHAF1B  
Affinity Capture-Western Homo sapiens
10 RC3H2  
Affinity Capture-MS Homo sapiens
11 AGO2 27161
Affinity Capture-Western Homo sapiens
12 CNOT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 TNRC6A 27327
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
14 ZSCAN1  
Two-hybrid Homo sapiens
15 RQCD1 9125
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
16 BTG3  
Affinity Capture-MS Homo sapiens
17 RAB29 8934
Affinity Capture-MS Homo sapiens
18 GADD45B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 CAPZA2 830
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 CNOT11 55571
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CAPZA1 829
Affinity Capture-MS Homo sapiens
22 RNF219  
Affinity Capture-MS Homo sapiens
23 BTG2 7832
Affinity Capture-MS Homo sapiens
24 CNOT3 4849
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
25 MAGEA9  
Affinity Capture-MS Homo sapiens
26 TNRC6B  
Affinity Capture-Western Homo sapiens
27 DCC  
Affinity Capture-MS Homo sapiens
28 TNKS1BP1 85456
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 Cnot3 232791
Affinity Capture-MS Mus musculus
30 NANOS1 340719
Affinity Capture-MS Homo sapiens
31 CNOT10 25904
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 PABPN1L  
Affinity Capture-MS Homo sapiens
33 TNRC6C  
Affinity Capture-Western Homo sapiens
34 FANCD2OS  
Affinity Capture-MS Homo sapiens
35 MAP4K4 9448
Affinity Capture-MS Homo sapiens
36 CNOT1 23019
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
37 CNOT8  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
38 CHAF1A  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
39 LRSAM1 90678
Affinity Capture-MS Homo sapiens
40 TLR3  
Affinity Capture-MS Homo sapiens
41 SCGN  
Affinity Capture-MS Homo sapiens
42 RIBC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 Cnot2  
Affinity Capture-MS Mus musculus
44 NFKB1 4790
Affinity Capture-MS Homo sapiens
45 PRC1 9055
Affinity Capture-MS Homo sapiens
46 GPBP1L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 TOB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 NANOS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 VASN 114990
Affinity Capture-MS Homo sapiens
50 LRRC40 55631
Affinity Capture-MS Homo sapiens
51 TMEM131  
Affinity Capture-MS Homo sapiens
52 FHL2 2274
Affinity Capture-MS Homo sapiens
53 CAPZB 832
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 CNOT6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 RC3H1 149041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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