Gene description for TNIP1
Gene name TNFAIP3 interacting protein 1
Gene symbol TNIP1
Other names/aliases ABIN-1
Species Homo sapiens
 Database cross references - TNIP1
ExoCarta ExoCarta_10318
Entrez Gene 10318
HGNC 16903
MIM 607714
UniProt Q15025  
 TNIP1 identified in exosomes derived from the following tissue/cell type
Melanoma cells 25950383    
 Gene ontology annotations for TNIP1
Molecular Function
    mitogen-activated protein kinase binding GO:0051019 IDA
    ubiquitin-specific protease activity GO:0004843 IDA
    protein binding GO:0005515 IPI
Biological Process
    defense response GO:0006952 TAS
    glycoprotein biosynthetic process GO:0009101 IDA
    modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade GO:0085032 IDA
    inflammatory response GO:0006954 IEA
    MyD88-dependent toll-like receptor signaling pathway GO:0002755 ISS
    translation GO:0006412 TAS
    negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 IDA
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IDA
    negative regulation of viral genome replication GO:0045071 TAS
    leukocyte cell-cell adhesion GO:0007159 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS
    positive regulation of inflammatory response GO:0050729 ISS
Subcellular Localization
    intracellular GO:0005622 TAS
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified TNIP1 in exosomes
Experiment ID 259
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for TNIP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TTF2  
Two-hybrid Homo sapiens
2 MAPK1 5594
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
3 RNF11 26994
Affinity Capture-MS Homo sapiens
4 TNFAIP3 7128
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
5 MGC33889  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which TNIP1 is involved
No pathways found

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