Gene description for ELF1
Gene name E74-like factor 1 (ets domain transcription factor)
Gene symbol ELF1
Other names/aliases -
Species Homo sapiens
 Database cross references - ELF1
ExoCarta ExoCarta_1997
Entrez Gene 1997
HGNC 3316
MIM 189973
UniProt P32519  
 ELF1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ELF1
Molecular Function
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    protein binding GO:0005515 IPI
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
Biological Process
    transcription, DNA-templated GO:0006351 IEA
    cell differentiation GO:0030154 IBA
    positive regulation of transcription, DNA-templated GO:0045893 NAS
    regulation of cytokine production GO:0001817 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    negative regulation of T cell receptor signaling pathway GO:0050860 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified ELF1 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ELF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RB1 5925
Affinity Capture-MS Homo sapiens
2 SP1  
Reconstituted Complex Homo sapiens
3 REL 5966
Reconstituted Complex Homo sapiens
4 NFKB1 4790
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
5 NFYB  
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
6 HMGA1 3159
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which ELF1 is involved
No pathways found

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