Gene description for PAK4
Gene name
p21 protein (Cdc42/Rac)-activated kinase 4
Gene symbol
PAK4
Other names/aliases
-
Species
Homo sapiens
Database cross references - PAK4
ExoCarta
ExoCarta_10298
Entrez Gene
10298
HGNC
16059
MIM
605451
UniProt
O96013
PAK4 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells
23333927
Ovarian cancer cells
23333927
Gene ontology annotations for PAK4
Experiment description of studies that identified PAK4 in exosomes
1
Experiment ID
211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
IGROV1
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
2
Experiment ID
212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
OVCAR-3
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for PAK4
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
SFN
2810
Affinity Capture-MS
Homo sapiens
2
CDC42
998
Affinity Capture-MS
Homo sapiens
Invivo
Homo sapiens
Invitro
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-Western
Homo sapiens
3
ITGAV
3685
Invitro
Homo sapiens
Two-hybrid
Homo sapiens
4
RAC1
5879
Affinity Capture-Western
Homo sapiens
5
YWHAG
7532
Affinity Capture-MS
Homo sapiens
6
ITGB5
3693
Affinity Capture-MS
Homo sapiens
Invivo
Homo sapiens
Two-hybrid
Homo sapiens
7
LIMK1
Reconstituted Complex
Homo sapiens
Biochemical Activity
Homo sapiens
8
YWHAZ
7534
Affinity Capture-MS
Homo sapiens
9
LRRK1
Affinity Capture-MS
Homo sapiens
10
YWHAQ
10971
Affinity Capture-MS
Homo sapiens
11
DLST
1743
Two-hybrid
Homo sapiens
View the network
image/svg+xml
Pathways in which PAK4 is involved