Gene description for TMEM107
Gene name transmembrane protein 107
Gene symbol TMEM107
Other names/aliases GRVS638
PRO1268
Species Homo sapiens
 Database cross references - TMEM107
ExoCarta ExoCarta_84314
Vesiclepedia VP_84314
Entrez Gene 84314
HGNC 28128
MIM 616183
UniProt Q6UX40  
 TMEM107 identified in sEVs derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for TMEM107
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    detection of nodal flow GO:0003127 IEA
    regulation of gene expression GO:0010468 IEA
    neural tube patterning GO:0021532 IEA
    embryonic digit morphogenesis GO:0042733 IEA
    roof of mouth development GO:0060021 IEA
    cilium assembly GO:0060271 IDA
    cilium assembly GO:0060271 ISS
    craniofacial suture morphogenesis GO:0097094 IEA
    protein localization to ciliary transition zone GO:1904491 IBA
    non-motile cilium assembly GO:1905515 IBA
    non-motile cilium assembly GO:1905515 IMP
Subcellular Localization
    membrane GO:0016020 IEA
    ciliary transition zone GO:0035869 IDA
    MKS complex GO:0036038 IBA
    MKS complex GO:0036038 IDA
 Experiment description of studies that identified TMEM107 in sEVs
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for TMEM107
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TMEM52B 120939
Two-hybrid Homo sapiens
2 CD40 958
Two-hybrid Homo sapiens
3 GJA8  
Two-hybrid Homo sapiens
4 GPX8 493869
Two-hybrid Homo sapiens
5 TMEM106A  
Two-hybrid Homo sapiens
6 CLN8 2055
Two-hybrid Homo sapiens
7 SLC30A2  
Two-hybrid Homo sapiens
8 EBAG9 9166
Two-hybrid Homo sapiens
9 ILF3 3609
Affinity Capture-RNA Homo sapiens
10 FZD2 2535
Affinity Capture-MS Homo sapiens
11 TMEM80  
Two-hybrid Homo sapiens
12 PIGP  
Two-hybrid Homo sapiens
13 PCNXL3 399909
Affinity Capture-MS Homo sapiens
14 FCER1G 2207
Two-hybrid Homo sapiens
15 ERGIC3 51614
Two-hybrid Homo sapiens
16 TMEM86B  
Two-hybrid Homo sapiens
17 TMEM139  
Two-hybrid Homo sapiens
18 SLC10A6  
Two-hybrid Homo sapiens
19 TMEM51 55092
Two-hybrid Homo sapiens
20 CD79A  
Two-hybrid Homo sapiens
21 AQP3  
Two-hybrid Homo sapiens
22 ATP11C 286410
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 MS4A3  
Two-hybrid Homo sapiens
24 TMEM179B 374395
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 FAM209A 200232
Two-hybrid Homo sapiens
26 SLC39A2  
Two-hybrid Homo sapiens
27 EVI2B 2124
Two-hybrid Homo sapiens
28 TMEM237 65062
Two-hybrid Homo sapiens
29 CLSTN3 9746
Two-hybrid Homo sapiens
30 CCL21  
Two-hybrid Homo sapiens
31 GJA5 2702
Two-hybrid Homo sapiens
32 PDZK1IP1 10158
Two-hybrid Homo sapiens
33 KCNJ6  
Two-hybrid Homo sapiens
34 TMEM234  
Two-hybrid Homo sapiens
35 VMA21  
Two-hybrid Homo sapiens
36 THAP4 51078
Two-hybrid Homo sapiens
37 SYT2  
Two-hybrid Homo sapiens
38 LHFPL5  
Two-hybrid Homo sapiens
39 PGRMC2 10424
Two-hybrid Homo sapiens
40 MGST3 4259
Two-hybrid Homo sapiens
41 KCNA5  
Two-hybrid Homo sapiens
42 FAM210B  
Two-hybrid Homo sapiens
43 TMEM31  
Two-hybrid Homo sapiens
44 TMEM167B  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TMEM107 is involved
No pathways found





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