Gene description for NCAPG2
Gene name non-SMC condensin II complex, subunit G2
Gene symbol NCAPG2
Other names/aliases CAP-G2
CAPG2
LUZP5
MTB
hCAP-G2
Species Homo sapiens
 Database cross references - NCAPG2
ExoCarta ExoCarta_54892
Vesiclepedia VP_54892
Entrez Gene 54892
HGNC 21904
MIM 608532
UniProt Q86XI2  
 NCAPG2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for NCAPG2
Molecular Function
    protein binding GO:0005515 IPI
    methylated histone binding GO:0035064 IDA
    bHLH transcription factor binding GO:0043425 IEA
Biological Process
    mitotic sister chromatid segregation GO:0000070 IBA
    inner cell mass cell proliferation GO:0001833 IEA
    transcription by RNA polymerase II GO:0006366 IEA
    erythrocyte differentiation GO:0030218 IEA
    chromosome condensation GO:0030261 IEA
    cell division GO:0051301 IEA
    positive regulation of chromosome segregation GO:0051984 ISO
    positive regulation of chromosome separation GO:1905820 ISO
    positive regulation of chromosome condensation GO:1905821 ISS
Subcellular Localization
    condensed nuclear chromosome GO:0000794 ISO
    condensin complex GO:0000796 IBA
    condensin complex GO:0000796 NAS
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    membrane GO:0016020 HDA
    nuclear speck GO:0016607 IDA
 Experiment description of studies that identified NCAPG2 in exosomes
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NCAPG2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DNAJC7 7266
Proximity Label-MS Homo sapiens
2 CD3EAP  
Proximity Label-MS Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 Cry1  
Affinity Capture-MS Mus musculus
5 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
6 ARMC5 79798
Affinity Capture-MS Homo sapiens
7 MAP2K2 5605
Affinity Capture-MS Homo sapiens
8 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
9 VIPR2  
Affinity Capture-MS Homo sapiens
10 RIC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 ACTBL2 345651
Affinity Capture-MS Homo sapiens
12 LAMP3  
Affinity Capture-MS Homo sapiens
13 OPALIN  
Affinity Capture-MS Homo sapiens
14 SSU72 29101
Co-fractionation Homo sapiens
15 CLPP 8192
Proximity Label-MS Homo sapiens
16 P2RY8  
Affinity Capture-MS Homo sapiens
17 NCAPH2  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 BSG 682
Affinity Capture-MS Homo sapiens
19 TAL1  
Two-hybrid Homo sapiens
20 CD6 923
Affinity Capture-MS Homo sapiens
21 MGARP  
Affinity Capture-MS Homo sapiens
22 CUL3 8452
Affinity Capture-MS Homo sapiens
23 CCP110  
Affinity Capture-MS Homo sapiens
24 C19orf38  
Affinity Capture-MS Homo sapiens
25 EGFR 1956
Affinity Capture-MS Homo sapiens
26 CTDP1 9150
Affinity Capture-MS Homo sapiens
27 FUS 2521
Affinity Capture-MS Homo sapiens
28 CLTB 1212
Co-fractionation Homo sapiens
29 FAXC  
Affinity Capture-MS Homo sapiens
30 ILVBL 10994
Affinity Capture-MS Homo sapiens
31 COMTD1 118881
Affinity Capture-MS Homo sapiens
32 ESR1  
Affinity Capture-Western Homo sapiens
33 VRK1 7443
Affinity Capture-MS Homo sapiens
34 TRIM52  
Affinity Capture-MS Homo sapiens
35 LZTS2 84445
Affinity Capture-MS Homo sapiens
36 FKBP5 2289
Affinity Capture-MS Homo sapiens
37 EPHA1 2041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 C12orf49  
Negative Genetic Homo sapiens
39 BSND  
Affinity Capture-MS Homo sapiens
40 NCAPD3 23310
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
41 SPN 6693
Affinity Capture-MS Homo sapiens
42 CDH5  
Affinity Capture-MS Homo sapiens
43 SOHLH1  
Affinity Capture-MS Homo sapiens
44 AMZ1  
Affinity Capture-MS Homo sapiens
45 ACTN4 81
Co-fractionation Homo sapiens
46 NTRK1 4914
Affinity Capture-MS Homo sapiens
47 GPR45  
Affinity Capture-MS Homo sapiens
48 NPDC1  
Affinity Capture-MS Homo sapiens
49 HLA-C 3107
Affinity Capture-MS Homo sapiens
50 GPR182  
Affinity Capture-MS Homo sapiens
51 FAM174A 345757
Affinity Capture-MS Homo sapiens
52 RAF1 5894
Affinity Capture-MS Homo sapiens
53 PTGES3 10728
Affinity Capture-MS Homo sapiens
54 DDRGK1 65992
Affinity Capture-MS Homo sapiens
55 ENTPD2 954
Affinity Capture-MS Homo sapiens
56 C9orf72  
Affinity Capture-MS Homo sapiens
57 HLA-DQB1 3119
Affinity Capture-MS Homo sapiens
58 KRAS 3845
Negative Genetic Homo sapiens
59 LRRC25  
Affinity Capture-MS Homo sapiens
60 NARS 4677
Affinity Capture-MS Homo sapiens
61 SMC2 10592
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
62 Smc4 70099
Affinity Capture-MS Mus musculus
63 FBXO38 81545
Proximity Label-MS Homo sapiens
64 Eea1  
Affinity Capture-MS Mus musculus
65 DGCR2 9993
Affinity Capture-MS Homo sapiens
66 ATG7 10533
Affinity Capture-MS Homo sapiens
67 CEBPA  
Protein-peptide Homo sapiens
View the network image/svg+xml
 Pathways in which NCAPG2 is involved
PathwayEvidenceSource
Cell Cycle TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Condensation of Prophase Chromosomes TAS Reactome
M Phase TAS Reactome
Mitotic Prophase TAS Reactome





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