Gene description for MICU2
Gene name mitochondrial calcium uptake 2
Gene symbol MICU2
Other names/aliases 1110008L20Rik
EFHA1
Species Homo sapiens
 Database cross references - MICU2
ExoCarta ExoCarta_221154
Vesiclepedia VP_221154
Entrez Gene 221154
HGNC 31830
MIM 610632
UniProt Q8IYU8  
 MICU2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MICU2
Molecular Function
    calcium channel regulator activity GO:0005246 IDA
    calcium ion binding GO:0005509 IBA
    calcium ion binding GO:0005509 IDA
    protein binding GO:0005515 IPI
    protein heterodimerization activity GO:0046982 IPI
    calcium ion sensor activity GO:0061891 IDA
Biological Process
    mitochondrial calcium ion transmembrane transport GO:0006851 IDA
    calcium import into the mitochondrion GO:0036444 IBA
    calcium import into the mitochondrion GO:0036444 IDA
    calcium import into the mitochondrion GO:0036444 IMP
    calcium import into the mitochondrion GO:0036444 NAS
    mitochondrial calcium ion homeostasis GO:0051560 IBA
    mitochondrial calcium ion homeostasis GO:0051560 IDA
    mitochondrial calcium ion homeostasis GO:0051560 IMP
    mitochondrial calcium ion homeostasis GO:0051560 NAS
    positive regulation of mitochondrial calcium ion concentration GO:0051561 IEA
    negative regulation of mitochondrial calcium ion concentration GO:0051562 IDA
    cellular response to calcium ion GO:0071277 IDA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 ISS
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 NAS
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial intermembrane space GO:0005758 IDA
    calcium channel complex GO:0034704 ISS
    uniplex complex GO:1990246 IBA
    uniplex complex GO:1990246 IDA
    uniplex complex GO:1990246 IPI
    uniplex complex GO:1990246 NAS
 Experiment description of studies that identified MICU2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MICU2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ASH2L 9070
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 MAGEA8  
Affinity Capture-MS Homo sapiens
3 SLC39A12  
Affinity Capture-MS Homo sapiens
4 LRRC23  
Affinity Capture-MS Homo sapiens
5 SNX27 81609
Affinity Capture-MS Homo sapiens
6 PHB2 11331
Proximity Label-MS Homo sapiens
7 CSNK1D 1453
Affinity Capture-MS Homo sapiens
8 SV2A 9900
Affinity Capture-MS Homo sapiens
9 SMAP1 60682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 SLC25A12 8604
Proximity Label-MS Homo sapiens
11 MAGEA3  
Affinity Capture-MS Homo sapiens
12 AIFM1 9131
Proximity Label-MS Homo sapiens
13 LCN6  
Affinity Capture-MS Homo sapiens
14 GIGYF2 26058
Affinity Capture-MS Homo sapiens
15 YTHDF1 54915
Affinity Capture-MS Homo sapiens
16 ZCCHC10  
Affinity Capture-MS Homo sapiens
17 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
18 ZSCAN20  
Affinity Capture-MS Homo sapiens
19 APOO 79135
Proximity Label-MS Homo sapiens
20 CDH5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 KIAA1217 56243
Affinity Capture-MS Homo sapiens
22 MGARP  
Affinity Capture-MS Homo sapiens
23 CALM1 801
Affinity Capture-MS Homo sapiens
24 CUL3 8452
Affinity Capture-MS Homo sapiens
25 ACOX3 8310
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 RPA3 6119
Proximity Label-MS Homo sapiens
27 CBWD2  
Affinity Capture-MS Homo sapiens
28 PKD1L2  
Affinity Capture-MS Homo sapiens
29 CMTR1 23070
Affinity Capture-MS Homo sapiens
30 BPNT1 10380
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 PARK2  
Affinity Capture-MS Homo sapiens
32 AQP3  
Affinity Capture-MS Homo sapiens
33 CXCR4 7852
Affinity Capture-MS Homo sapiens
34 DDX58 23586
Affinity Capture-RNA Homo sapiens
35 DCAF11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 SPACA1 81833
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 SFXN1 94081
Proximity Label-MS Homo sapiens
38 KLHL22 84861
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 DIABLO 56616
Proximity Label-MS Homo sapiens
40 CHCHD4  
Affinity Capture-MS Homo sapiens
41 ARMC6 93436
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 PON1 5444
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 ABTB2 25841
Affinity Capture-MS Homo sapiens
44 TRIM44  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 TUBB 203068
Affinity Capture-MS Homo sapiens
46 RPA2 6118
Proximity Label-MS Homo sapiens
47 TIMM8A 1678
Affinity Capture-MS Homo sapiens
48 TBC1D22A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 GAPVD1 26130
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 CPLX4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 SLC25A51  
Proximity Label-MS Homo sapiens
52 LRPAP1 4043
Affinity Capture-MS Homo sapiens
53 GPR182  
Affinity Capture-MS Homo sapiens
54 OPA1 4976
Proximity Label-MS Homo sapiens
55 NAGA 4668
Affinity Capture-MS Homo sapiens
56 COPS5 10987
Affinity Capture-MS Homo sapiens
57 PYCRL 65263
Affinity Capture-MS Homo sapiens
58 CPSF7 79869
Affinity Capture-MS Homo sapiens
59 CSNK1E 1454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 SLC1A1 6505
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 RBBP5 5929
Affinity Capture-MS Homo sapiens
62 ACTA2 59
Affinity Capture-MS Homo sapiens
63 RANBP6 26953
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 MICU1 10367
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 LURAP1  
Affinity Capture-MS Homo sapiens
66 AKAP1 8165
Proximity Label-MS Homo sapiens
67 C2orf49 79074
Affinity Capture-MS Homo sapiens
68 ATG7 10533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 COX4I1 1327
Proximity Label-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here