Gene description for UROS
Gene name uroporphyrinogen III synthase
Gene symbol UROS
Other names/aliases UROIIIS
Species Homo sapiens
 Database cross references - UROS
ExoCarta ExoCarta_7390
Vesiclepedia VP_7390
Entrez Gene 7390
HGNC 12592
MIM 606938
UniProt P10746  
 UROS identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for UROS
Molecular Function
    uroporphyrinogen-III synthase activity GO:0004852 IBA
    uroporphyrinogen-III synthase activity GO:0004852 IDA
    uroporphyrinogen-III synthase activity GO:0004852 TAS
    folic acid binding GO:0005542 IEA
Biological Process
    uroporphyrinogen III biosynthetic process GO:0006780 IBA
    uroporphyrinogen III biosynthetic process GO:0006780 IDA
    protoporphyrinogen IX biosynthetic process GO:0006782 IEA
    heme biosynthetic process GO:0006783 IC
    heme biosynthetic process GO:0006783 IDA
    heme biosynthetic process GO:0006783 TAS
    heme A biosynthetic process GO:0006784 IEA
    heme B biosynthetic process GO:0006785 IEA
    heme O biosynthetic process GO:0048034 IEA
    response to platinum ion GO:0070541 IEA
    cellular response to arsenic-containing substance GO:0071243 IEA
    cellular response to amine stimulus GO:0071418 IEA
Subcellular Localization
    mitochondrion GO:0005739 ISS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 NAS
    cytosol GO:0005829 TAS
 Experiment description of studies that identified UROS in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for UROS
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COPS5 10987
Affinity Capture-MS Homo sapiens
2 LDLR 3949
Negative Genetic Homo sapiens
3 MOCS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 TRIM25 7706
Co-fractionation Homo sapiens
5 TCEAL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 FASN 2194
Negative Genetic Homo sapiens
7 GCLM 2730
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 PNPLA4  
Affinity Capture-MS Homo sapiens
9 UBQLN4 56893
Two-hybrid Homo sapiens
10 SREBF2 6721
Positive Genetic Homo sapiens
11 EGFR 1956
Negative Genetic Homo sapiens
12 CTU2 348180
Affinity Capture-MS Homo sapiens
13 CTU1 90353
Affinity Capture-MS Homo sapiens
14 BOLA1 51027
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 WISP2 8839
Affinity Capture-MS Homo sapiens
16 EED  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 ATG7 10533
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which UROS is involved
PathwayEvidenceSource
Heme biosynthesis TAS Reactome
Metabolism TAS Reactome
Metabolism of porphyrins TAS Reactome





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