Gene description for STXBP6
Gene name syntaxin binding protein 6 (amisyn)
Gene symbol STXBP6
Other names/aliases HSPC156
amisyn
Species Homo sapiens
 Database cross references - STXBP6
ExoCarta ExoCarta_29091
Vesiclepedia VP_29091
Entrez Gene 29091
HGNC 19666
MIM 607958
UniProt Q8NFX7  
 STXBP6 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for STXBP6
Molecular Function
    cadherin binding involved in cell-cell adhesion GO:0098641 HDA
Biological Process
    SNARE complex assembly GO:0035493 IDA
    regulation of SNARE complex assembly GO:0035542 IEA
    negative regulation of exocytosis GO:0045920 TAS
    cell-cell adhesion GO:0098609 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    adherens junction GO:0005912 HDA
    membrane GO:0016020 IEA
 Experiment description of studies that identified STXBP6 in exosomes
1
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for STXBP6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EPHA2 1969
Proximity Label-MS Homo sapiens
2 XPNPEP1 7511
Affinity Capture-MS Homo sapiens
3 STX8 9482
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 NAPG 8774
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 STX7 8417
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 VTI1B 10490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 STX10 8677
Affinity Capture-MS Homo sapiens
8 CDH1 999
Proximity Label-MS Homo sapiens
9 STX1A 6804
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 SNAP29 9342
Affinity Capture-MS Homo sapiens
11 STX3 6809
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 SNAP23 8773
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 EXOC1 55763
Negative Genetic Homo sapiens
14 ALS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 STX6 10228
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 STX4 6810
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 NAPA 8775
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 ATG7 10533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 STX12 23673
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which STXBP6 is involved
No pathways found





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