Gene description for LLGL1
Gene name lethal giant larvae homolog 1 (Drosophila)
Gene symbol LLGL1
Other names/aliases DLG4
Species Homo sapiens
 Database cross references - LLGL1
ExoCarta ExoCarta_3996
Entrez Gene 3996
HGNC 6628
MIM 600966
UniProt Q15334  
 LLGL1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for LLGL1
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IDA
    GTPase activator activity GO:0005096 ISS
    structural molecule activity GO:0005198 TAS
Biological Process
    protein complex assembly GO:0006461 IDA
    positive regulation of GTPase activity GO:0043547 ISS
    Golgi to plasma membrane transport GO:0006893 ISS
    exocytosis GO:0006887 IEA
    axonogenesis GO:0007409 ISS
    cortical actin cytoskeleton organization GO:0030866 IDA
    maintenance of apical/basal cell polarity GO:0035090 IEA
Subcellular Localization
    axon GO:0030424 ISS
    trans-Golgi network membrane GO:0032588 ISS
    cytoskeleton GO:0005856 TAS
    Golgi cis cisterna GO:0000137 ISS
    early endosome membrane GO:0031901 ISS
    myelin sheath abaxonal region GO:0035748 IEA
    cytoplasm GO:0005737 IDA
    cortical actin cytoskeleton GO:0030864 IDA
 Experiment description of studies that identified LLGL1 in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for LLGL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD46 4179
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which LLGL1 is involved
No pathways found

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