Gene description for GTF2F1
Gene name general transcription factor IIF, polypeptide 1, 74kDa
Gene symbol GTF2F1
Other names/aliases BTF4
RAP74
TF2F1
TFIIF
Species Homo sapiens
 Database cross references - GTF2F1
ExoCarta ExoCarta_2962
Vesiclepedia VP_2962
Entrez Gene 2962
HGNC 4652
MIM 189968
UniProt P35269  
 GTF2F1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Hepatocytes 26054723    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
 Gene ontology annotations for GTF2F1
Molecular Function
    RNA polymerase II general transcription initiation factor binding GO:0001091 IPI
    TFIIF-class transcription factor complex binding GO:0001096 IBA
    DNA binding GO:0003677 IEA
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    RNA polymerase II general transcription initiation factor activity GO:0016251 IBA
    RNA polymerase II general transcription initiation factor activity GO:0016251 IDA
    phosphatase activator activity GO:0019211 IDA
    protein phosphatase binding GO:0019903 IPI
    protein domain specific binding GO:0019904 IPI
    promoter-specific chromatin binding GO:1990841 IDA
Biological Process
    transcription by RNA polymerase II GO:0006366 TAS
    transcription initiation at RNA polymerase II promoter GO:0006367 IBA
    transcription initiation at RNA polymerase II promoter GO:0006367 IDA
    transcription elongation by RNA polymerase II GO:0006368 IDA
    response to virus GO:0009615 IEP
    negative regulation of protein binding GO:0032091 IMP
    positive regulation of transcription elongation by RNA polymerase II GO:0032968 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
Subcellular Localization
    nucleus GO:0005634 IMP
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    transcription factor TFIID complex GO:0005669 IDA
    transcription factor TFIIF complex GO:0005674 IBA
    transcription factor TFIIF complex GO:0005674 IPI
    cell junction GO:0030054 IDA
    protein-containing complex GO:0032991 IMP
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified GTF2F1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
12
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GTF2F1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNL2 29889
Affinity Capture-MS Homo sapiens
2 POLR2B 5431
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CDC14B 8555
Proximity Label-MS Homo sapiens
4 SLFN11 91607
Affinity Capture-MS Homo sapiens
5 UBE2H 7328
Affinity Capture-MS Homo sapiens
6 POLR2G 5436
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
7 POLR2H 5437
Co-fractionation Homo sapiens
8 SPRTN  
Affinity Capture-MS Homo sapiens
9 CCNH  
Co-fractionation Homo sapiens
10 COIL  
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
11 EEF1G 1937
Co-fractionation Homo sapiens
12 ERCC2 2068
Affinity Capture-Western Homo sapiens
13 PFKP 5214
Co-fractionation Homo sapiens
14 Gtf2b  
Affinity Capture-MS Mus musculus
15 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
16 ACTC1 70
Proximity Label-MS Homo sapiens
17 BRCA1 672
Co-purification Homo sapiens
18 RPS19 6223
Co-fractionation Homo sapiens
19 TRIM27  
Two-hybrid Homo sapiens
20 FAM21A 387680
Co-fractionation Homo sapiens
21 CSNK2A1 1457
Biochemical Activity Homo sapiens
22 KPNA2 3838
Affinity Capture-MS Homo sapiens
23 TAF1  
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
24 GTF2H2  
Affinity Capture-MS Homo sapiens
25 VPS29 51699
Co-fractionation Homo sapiens
26 CENPA  
Proximity Label-MS Homo sapiens
27 DEGS1  
Affinity Capture-MS Homo sapiens
28 TCEA1 6917
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
29 GTF2H2C  
Affinity Capture-MS Homo sapiens
30 GTF2F2 2963
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
31 HIRIP3  
Co-fractionation Homo sapiens
32 TBP  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
33 POLR1E  
Proximity Label-MS Homo sapiens
34 PRPS1 5631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 PSMC2 5701
Affinity Capture-Western Homo sapiens
36 NIFK 84365
Proximity Label-MS Homo sapiens
37 APEX1 328
Proximity Label-MS Homo sapiens
38 KIF2C 11004
Affinity Capture-MS Homo sapiens
39 POLR2C 5432
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
40 NOP56 10528
Proximity Label-MS Homo sapiens
41 SERF2 10169
Affinity Capture-MS Homo sapiens
42 CREBBP  
Co-fractionation Homo sapiens
43 ASF1A 25842
Proximity Label-MS Homo sapiens
44 SMARCB1 6598
Co-fractionation Homo sapiens
45 CCNC  
Affinity Capture-Western Homo sapiens
46 MAD2L1 4085
Affinity Capture-MS Homo sapiens
47 KIF21A 55605
Co-fractionation Homo sapiens
48 PSMC3 5702
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 PSME3 10197
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 UBR4 23352
Co-fractionation Homo sapiens
51 BOD1L1 259282
Co-fractionation Homo sapiens
52 JMJD6 23210
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 PSENEN  
Affinity Capture-MS Homo sapiens
54 CTDP1 9150
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
55 MEPCE 56257
Affinity Capture-MS Homo sapiens
56 MSX2  
Reconstituted Complex Homo sapiens
57 PRPS2 5634
Affinity Capture-MS Homo sapiens
58 MAGEC1  
Two-hybrid Homo sapiens
59 TAF11  
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
60 AKR7L 246181
Affinity Capture-MS Homo sapiens
61 SMARCA4 6597
Co-fractionation Homo sapiens
62 GTF2H1 2965
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
63 DRAP1 10589
Co-fractionation Homo sapiens
64 NTRK1 4914
Affinity Capture-MS Homo sapiens
65 CIRBP 1153
Co-fractionation Homo sapiens
66 RPL31 6160
Proximity Label-MS Homo sapiens
67 ARNT 405
Reconstituted Complex Homo sapiens
68 NCL 4691
Co-fractionation Homo sapiens
69 SRF  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
70 PRMT2  
Affinity Capture-MS Homo sapiens
71 KPNB1 3837
Co-fractionation Homo sapiens
72 SNRNP27  
Affinity Capture-MS Homo sapiens
73 RFC2 5982
Affinity Capture-MS Homo sapiens
74 CDH23 64072
Affinity Capture-MS Homo sapiens
75 EFTUD2 9343
Co-fractionation Homo sapiens
76 Wipi2 74781
Affinity Capture-MS Mus musculus
77 KIAA1033 23325
Co-fractionation Homo sapiens
78 CEBPA  
Protein-peptide Homo sapiens
79 MYO18A 399687
Co-fractionation Homo sapiens
80 SF3A3 10946
Co-fractionation Homo sapiens
81 CCNT1  
Biochemical Activity Homo sapiens
82 SMARCC2 6601
Co-fractionation Homo sapiens
83 CD3EAP  
Proximity Label-MS Homo sapiens
84 GTF2A1 2957
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
85 PTN  
Two-hybrid Homo sapiens
86 C1QTNF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 TAF7  
Co-fractionation Homo sapiens
88 LPPR1  
Affinity Capture-MS Homo sapiens
89 TUBB 203068
Co-fractionation Homo sapiens
90 PCDH20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 CDC73  
Co-fractionation Homo sapiens
92 CDK9 1025
Biochemical Activity Homo sapiens
Co-fractionation Homo sapiens
93 PRDM11  
Affinity Capture-MS Homo sapiens
94 TCEAL7  
Affinity Capture-MS Homo sapiens
95 XPO1 7514
Affinity Capture-MS Homo sapiens
96 BAG2 9532
Affinity Capture-MS Homo sapiens
97 STAC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 NAP1L4 4676
Co-fractionation Homo sapiens
99 POLR2E 5434
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
100 KCTD12 115207
Affinity Capture-MS Homo sapiens
101 RPL14 9045
Cross-Linking-MS (XL-MS) Homo sapiens
102 THOC5 8563
Affinity Capture-MS Homo sapiens
103 POLR2D  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
104 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
105 NAP1L1 4673
Co-fractionation Homo sapiens
106 EEF1B2 1933
Co-fractionation Homo sapiens
107 SNF8 11267
Co-fractionation Homo sapiens
108 POLR2A 5430
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
109 CCDC71  
Affinity Capture-MS Homo sapiens
110 MYO1C 4641
Affinity Capture-MS Homo sapiens
111 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
112 DUS3L 56931
Co-fractionation Homo sapiens
113 JUN 3725
Reconstituted Complex Homo sapiens
114 PRMT5 10419
Co-fractionation Homo sapiens
115 PRKACA 5566
Cross-Linking-MS (XL-MS) Homo sapiens
116 PIP4K2A 5305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 LBH  
Affinity Capture-MS Homo sapiens
118 PYCRL 65263
Affinity Capture-MS Homo sapiens
119 FOS 2353
Reconstituted Complex Homo sapiens
120 KIF1BP 26128
Co-fractionation Homo sapiens
121 MYC  
Reconstituted Complex Homo sapiens
122 RPA3 6119
Proximity Label-MS Homo sapiens
123 SF3A1 10291
Co-fractionation Homo sapiens
124 AHR 196
Reconstituted Complex Homo sapiens
125 PSAP 5660
Co-fractionation Homo sapiens
126 RPL35A 6165
Affinity Capture-MS Homo sapiens
127 S100B 6285
Affinity Capture-MS Homo sapiens
128 DDRGK1 65992
Affinity Capture-MS Homo sapiens
129 SMARCA2 6595
Co-fractionation Homo sapiens
130 PUS1 80324
Co-fractionation Homo sapiens
131 SPANXA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 U2SURP 23350
Co-fractionation Homo sapiens
133 Gtf3c6  
Affinity Capture-MS Mus musculus
134 TAF6 6878
Co-fractionation Homo sapiens
135 FEZ1  
Two-hybrid Homo sapiens
136 MRPL42  
Affinity Capture-MS Homo sapiens
137 SRRM1 10250
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
138 POLR2F  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 PARP1 142
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
140 WDR77 79084
Co-fractionation Homo sapiens
141 POLR2J  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 TP53 7157
Co-fractionation Homo sapiens
143 CDK8 1024
Affinity Capture-Western Homo sapiens
144 DSCC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 STK38 11329
Co-fractionation Homo sapiens
146 SRSF9 8683
Co-fractionation Homo sapiens
147 SMARCC1 6599
Co-fractionation Homo sapiens
148 GRHPR 9380
Affinity Capture-MS Homo sapiens
149 SNRPA 6626
Co-fractionation Homo sapiens
150 FGB 2244
Affinity Capture-MS Homo sapiens
151 ABL1 25
Far Western Homo sapiens
152 C1orf35  
Affinity Capture-MS Homo sapiens
153 PHF19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
154 POLR2K  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
155 GTF2H5  
Affinity Capture-MS Homo sapiens
156 GNL1 2794
Co-fractionation Homo sapiens
157 DDX23 9416
Proximity Label-MS Homo sapiens
158 GTF2B 2959
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
159 WIF1 11197
Affinity Capture-MS Homo sapiens
160 ERCC3  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
161 FGF9  
Affinity Capture-MS Homo sapiens
162 MED21  
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
163 RPL23A 6147
Cross-Linking-MS (XL-MS) Homo sapiens
164 RPS24 6229
Proximity Label-MS Homo sapiens
165 MMS19 64210
Co-fractionation Homo sapiens
166 GTF2H3  
Affinity Capture-MS Homo sapiens
167 SPCS1 28972
Affinity Capture-MS Homo sapiens
168 Dctn3  
Affinity Capture-MS Mus musculus
169 EEF1D 1936
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
170 ATG4B 23192
Affinity Capture-MS Homo sapiens
171 EAF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
172 SSSCA1 10534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
173 GTF2E1 2960
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
174 XRCC6 2547
Proximity Label-MS Homo sapiens
175 GTF2H4 2968
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
176 KRAS 3845
Negative Genetic Homo sapiens
177 HNRNPU 3192
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
178 AR 367
Reconstituted Complex Homo sapiens
179 TUBB8 347688
Co-fractionation Homo sapiens
180 BCAT1 586
Co-fractionation Homo sapiens
181 CDK16 5127
Affinity Capture-MS Homo sapiens
182 GTF2E2  
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which GTF2F1 is involved
PathwayEvidenceSource
Abortive elongation of HIV-1 transcript in the absence of Tat IEA Reactome
Disease IEA Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers IEA Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
FGFR2 alternative splicing TAS Reactome
FGFR2 mutant receptor activation IEA Reactome
Formation of HIV elongation complex in the absence of HIV Tat IEA Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat TAS Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat IEA Reactome
Formation of RNA Pol II elongation complex TAS Reactome
Formation of the Early Elongation Complex TAS Reactome
Formation of the HIV-1 Early Elongation Complex IEA Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway TAS Reactome
HIV elongation arrest and recovery IEA Reactome
HIV Infection IEA Reactome
HIV Infection TAS Reactome
HIV Life Cycle IEA Reactome
HIV Life Cycle TAS Reactome
HIV Transcription Elongation TAS Reactome
HIV Transcription Elongation IEA Reactome
HIV Transcription Initiation IEA Reactome
Infectious disease IEA Reactome
Infectious disease TAS Reactome
Influenza Infection TAS Reactome
Influenza Viral RNA Transcription and Replication TAS Reactome
Late Phase of HIV Life Cycle IEA Reactome
Late Phase of HIV Life Cycle TAS Reactome
Metabolism of RNA TAS Reactome
mRNA Capping TAS Reactome
mRNA Splicing TAS Reactome
mRNA Splicing - Major Pathway TAS Reactome
mRNA Splicing - Minor Pathway TAS Reactome
Pausing and recovery of HIV elongation IEA Reactome
Pausing and recovery of Tat-mediated HIV elongation IEA Reactome
Processing of Capped Intron-Containing Pre-mRNA TAS Reactome
RNA Pol II CTD phosphorylation and interaction with CE TAS Reactome
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection IEA Reactome
RNA Polymerase II HIV Promoter Escape IEA Reactome
RNA Polymerase II Pre-transcription Events TAS Reactome
RNA Polymerase II Promoter Escape TAS Reactome
RNA polymerase II transcribes snRNA genes TAS Reactome
RNA polymerase II transcribes snRNA genes IEA Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RNA Polymerase II Transcription Elongation TAS Reactome
RNA Polymerase II Transcription Initiation TAS Reactome
RNA Polymerase II Transcription Initiation And Promoter Clearance TAS Reactome
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening TAS Reactome
Signal Transduction TAS Reactome
Signaling by FGFR TAS Reactome
Signaling by FGFR in disease IEA Reactome
Signaling by FGFR2 TAS Reactome
Signaling by FGFR2 IIIa TM IEA Reactome
Signaling by FGFR2 in disease IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Tat-mediated elongation of the HIV-1 transcript IEA Reactome
Tat-mediated elongation of the HIV-1 transcript TAS Reactome
Tat-mediated HIV elongation arrest and recovery IEA Reactome
TP53 Regulates Transcription of DNA Repair Genes TAS Reactome
Transcription of the HIV genome IEA Reactome
Transcription of the HIV genome TAS Reactome
Transcriptional Regulation by TP53 TAS Reactome
Viral Infection Pathways IEA Reactome
Viral Infection Pathways TAS Reactome
Viral Messenger RNA Synthesis TAS Reactome





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