Gene description for STAG2
Gene name stromal antigen 2
Gene symbol STAG2
Other names/aliases SA-2
SA2
SCC3B
bA517O1.1
Species Homo sapiens
 Database cross references - STAG2
ExoCarta ExoCarta_10735
Vesiclepedia VP_10735
Entrez Gene 10735
HGNC 11355
MIM 300826
UniProt Q8N3U4  
 STAG2 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 34887515    
Neuroblastoma cells 25944692    
 Gene ontology annotations for STAG2
Molecular Function
    chromatin binding GO:0003682 IBA
    protein binding GO:0005515 IPI
Biological Process
    sister chromatid cohesion GO:0007062 IBA
    sister chromatid cohesion GO:0007062 IMP
    establishment of mitotic sister chromatid cohesion GO:0034087 NAS
    cell division GO:0051301 IEA
    meiotic cell cycle GO:0051321 IEA
    mitotic spindle assembly GO:0090307 IMP
Subcellular Localization
    chromosome, centromeric region GO:0000775 TAS
    chromatin GO:0000785 IBA
    chromatin GO:0000785 IDA
    fibrillar center GO:0001650 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 NAS
    nucleus GO:0005634 TAS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    chromosome GO:0005694 TAS
    nucleolus GO:0005730 IDA
    cytosol GO:0005829 TAS
    cohesin complex GO:0008278 IBA
    cohesin complex GO:0008278 IDA
    cohesin complex GO:0008278 IMP
    membrane GO:0016020 HDA
    nuclear matrix GO:0016363 IDA
    mitotic cohesin complex GO:0030892 IPI
    mitotic spindle pole GO:0097431 IDA
 Experiment description of studies that identified STAG2 in exosomes
1
Experiment ID 1203
MISEV standards
EM
Biophysical techniques
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
2
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for STAG2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDCA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 CITED1 4435
Affinity Capture-MS Homo sapiens
3 SMC3 9126
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
4 C5AR1  
Affinity Capture-MS Homo sapiens
5 REC8  
Affinity Capture-MS Homo sapiens
6 Smc1a  
Affinity Capture-MS Mus musculus
7 COIL  
Proximity Label-MS Homo sapiens
8 KPNA1 3836
Affinity Capture-MS Homo sapiens
9 BZW2 28969
Co-fractionation Homo sapiens
10 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
11 CCDC102B  
Affinity Capture-MS Homo sapiens
12 PNKD  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 CENPA  
Proximity Label-MS Homo sapiens
14 APEX1 328
Proximity Label-MS Homo sapiens
15 KIAA1429 25962
Affinity Capture-MS Homo sapiens
16 GYPA  
Affinity Capture-MS Homo sapiens
17 EXOSC2 23404
Co-fractionation Homo sapiens
18 KDM2A  
Co-fractionation Homo sapiens
19 OPRM1 4988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 SRRM2 23524
Co-fractionation Homo sapiens
21 MAD2L2 10459
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 SEMA4C 54910
Affinity Capture-MS Homo sapiens
23 EPHA1 2041
Affinity Capture-MS Homo sapiens
24 ITFG3 83986
Affinity Capture-MS Homo sapiens
25 KLHL20  
Affinity Capture-MS Homo sapiens
26 GYPB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 OBSL1 23363
Affinity Capture-MS Homo sapiens
28 GPR17 2840
Affinity Capture-MS Homo sapiens
29 USP37  
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
30 PDS5B 23047
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 EXOSC9 5393
Co-fractionation Homo sapiens
32 VSIG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 CD70 970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 GPR183  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
36 SMARCA5 8467
Co-fractionation Homo sapiens
37 PARK2  
Affinity Capture-MS Homo sapiens
38 COPE 11316
Co-fractionation Homo sapiens
39 Smc3 13006
Affinity Capture-MS Mus musculus
40 CBX3 11335
Proximity Label-MS Homo sapiens
41 COMTD1 118881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 Rad21  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
43 TUBA1B 10376
Affinity Capture-MS Homo sapiens
44 PDS5A 23244
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
45 VCP 7415
Affinity Capture-MS Homo sapiens
46 NTRK1 4914
Affinity Capture-MS Homo sapiens
47 Stag2  
Affinity Capture-MS Mus musculus
48 PLK1 5347
Biochemical Activity Homo sapiens
49 SPRR1B 6699
Affinity Capture-MS Homo sapiens
50 ENO1 2023
Cross-Linking-MS (XL-MS) Homo sapiens
51 SMC1A 8243
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
52 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
53 MBD3 53615
Co-fractionation Homo sapiens
54 CEBPA  
Proximity Label-MS Homo sapiens
55 RAD21 5885
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
56 PIPSL 266971
Affinity Capture-MS Homo sapiens
57 MLNR  
Affinity Capture-MS Homo sapiens
58 CD3EAP  
Proximity Label-MS Homo sapiens
59 CD40 958
Affinity Capture-MS Homo sapiens
60 SFPQ 6421
Co-fractionation Homo sapiens
61 EFNA4  
Affinity Capture-MS Homo sapiens
62 FANCD2  
Affinity Capture-MS Homo sapiens
63 WFDC5  
Affinity Capture-Western Homo sapiens
64 SIGLECL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 BTNL9  
Affinity Capture-MS Homo sapiens
66 CD83  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 HIGD1A 25994
Affinity Capture-MS Homo sapiens
68 NSMCE2  
Co-fractionation Homo sapiens
69 SIRT7  
Affinity Capture-MS Homo sapiens
70 SMC1B  
Co-fractionation Homo sapiens
71 NPTN 27020
Affinity Capture-MS Homo sapiens
72 PIP5K1P1  
Affinity Capture-MS Homo sapiens
73 CUL3 8452
Affinity Capture-MS Homo sapiens
74 NR3C1 2908
Proximity Label-MS Homo sapiens
75 ERCC4  
Affinity Capture-MS Homo sapiens
76 HLA-DRB5 3127
Affinity Capture-MS Homo sapiens
77 FNTA 2339
Affinity Capture-MS Homo sapiens
78 WAPAL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 OCIAD1 54940
Affinity Capture-MS Homo sapiens
80 C3orf18  
Affinity Capture-MS Homo sapiens
81 RPA3 6119
Proximity Label-MS Homo sapiens
82 NHP2L1 4809
Co-fractionation Homo sapiens
83 NIPBL 25836
Affinity Capture-MS Homo sapiens
84 Cdca5  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
85 MTA2 9219
Co-fractionation Homo sapiens
86 PIP5K1A 8394
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 FTL 2512
Affinity Capture-MS Homo sapiens
88 RBM14 10432
Co-fractionation Homo sapiens
89 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
90 ALDH3A2 224
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 PARP1 142
Proximity Label-MS Homo sapiens
92 SRRM1 10250
Affinity Capture-MS Homo sapiens
93 SSU72 29101
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
94 FOXB1  
Affinity Capture-MS Homo sapiens
95 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
96 EFNB1 1947
Affinity Capture-MS Homo sapiens
97 DDX58 23586
Affinity Capture-RNA Homo sapiens
98 DCD 117159
Affinity Capture-MS Homo sapiens
99 STAG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
100 NCL 4691
Cross-Linking-MS (XL-MS) Homo sapiens
101 KIR2DL4  
Affinity Capture-MS Homo sapiens
102 CDC5L 988
Affinity Capture-MS Homo sapiens
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