Gene description for ARHGEF10L
Gene name Rho guanine nucleotide exchange factor (GEF) 10-like
Gene symbol ARHGEF10L
Other names/aliases GrinchGEF
Species Homo sapiens
 Database cross references - ARHGEF10L
ExoCarta ExoCarta_55160
Vesiclepedia VP_55160
Entrez Gene 55160
HGNC 25540
MIM 612494
UniProt Q9HCE6  
 ARHGEF10L identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ARHGEF10L
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    guanyl-nucleotide exchange factor activity GO:0005085 TAS
    GTPase activator activity GO:0005096 IDA
Biological Process
    actin cytoskeleton organization GO:0030036 IBA
    SREBP signaling pathway GO:0032933 IBA
    SREBP signaling pathway GO:0032933 IDA
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    positive regulation of stress fiber assembly GO:0051496 IBA
    positive regulation of stress fiber assembly GO:0051496 IDA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified ARHGEF10L in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ARHGEF10L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 SRGAP1 57522
Affinity Capture-MS Homo sapiens
3 CSE1L 1434
Affinity Capture-MS Homo sapiens
4 MCM7 4176
Affinity Capture-MS Homo sapiens
5 NHP2 55651
Affinity Capture-MS Homo sapiens
6 RPS27A 6233
Affinity Capture-MS Homo sapiens
7 SSR3 6747
Affinity Capture-MS Homo sapiens
8 SMC1A 8243
Affinity Capture-MS Homo sapiens
9 GLOD4 51031
Affinity Capture-MS Homo sapiens
10 PRPF4B 8899
Affinity Capture-MS Homo sapiens
11 SRRM1 10250
Affinity Capture-MS Homo sapiens
12 TRMT10C 54931
Affinity Capture-MS Homo sapiens
13 LSM12 124801
Affinity Capture-MS Homo sapiens
14 SRPRB 58477
Affinity Capture-MS Homo sapiens
15 PCMT1 5110
Affinity Capture-MS Homo sapiens
16 DDX19B 11269
Affinity Capture-MS Homo sapiens
17 TARDBP 23435
Affinity Capture-MS Homo sapiens
18 BAG5 9529
Affinity Capture-MS Homo sapiens
19 DDX50 79009
Affinity Capture-MS Homo sapiens
20 SRPR 6734
Affinity Capture-MS Homo sapiens
21 ARCN1 372
Affinity Capture-MS Homo sapiens
22 XRN2 22803
Affinity Capture-MS Homo sapiens
23 CAND1 55832
Affinity Capture-MS Homo sapiens
24 NDUFA4 4697
Affinity Capture-MS Homo sapiens
25 CFL1 1072
Affinity Capture-MS Homo sapiens
26 STOML2 30968
Affinity Capture-MS Homo sapiens
27 FEM1B 10116
Affinity Capture-MS Homo sapiens
28 CHCHD3 54927
Affinity Capture-MS Homo sapiens
29 COPG1 22820
Affinity Capture-MS Homo sapiens
30 TUBB4A 10382
Affinity Capture-MS Homo sapiens
31 BRIX1 55299
Affinity Capture-MS Homo sapiens
32 UBAP2L 9898
Affinity Capture-MS Homo sapiens
33 SFXN1 94081
Affinity Capture-MS Homo sapiens
34 STIP1 10963
Affinity Capture-MS Homo sapiens
35 COPB1 1315
Affinity Capture-MS Homo sapiens
36 EBNA1BP2 10969
Affinity Capture-MS Homo sapiens
37 RUVBL1 8607
Affinity Capture-MS Homo sapiens
38 PSPC1 55269
Affinity Capture-MS Homo sapiens
39 SERPINH1 871
Affinity Capture-MS Homo sapiens
40 CDK9 1025
Affinity Capture-MS Homo sapiens
41 RFWD2  
Affinity Capture-MS Homo sapiens
42 ANXA5 308
Affinity Capture-MS Homo sapiens
43 COPB2 9276
Affinity Capture-MS Homo sapiens
44 HP1BP3 50809
Affinity Capture-MS Homo sapiens
45 PTGES3 10728
Affinity Capture-MS Homo sapiens
46 ATP5C1 509
Affinity Capture-MS Homo sapiens
47 OR2A4 79541
Affinity Capture-MS Homo sapiens
48 HSPA4L 22824
Affinity Capture-MS Homo sapiens
49 PSMC6 5706
Affinity Capture-MS Homo sapiens
50 CKAP4 10970
Affinity Capture-MS Homo sapiens
51 ARHGEF10 9639
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 CCR1  
Affinity Capture-MS Homo sapiens
53 ADAR 103
Affinity Capture-MS Homo sapiens
54 NOP58 51602
Affinity Capture-MS Homo sapiens
55 RPRD1A  
Affinity Capture-MS Homo sapiens
56 QPCTL 54814
Affinity Capture-MS Homo sapiens
57 WASL 8976
Affinity Capture-MS Homo sapiens
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