Gene description for ST5
Gene name suppression of tumorigenicity 5
Gene symbol ST5
Other names/aliases DENND2B
Species Homo sapiens
 Database cross references - ST5
ExoCarta ExoCarta_6764
Entrez Gene 6764
HGNC 11350
MIM 140750
UniProt P78524  
 ST5 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ST5
Molecular Function
    Rab guanyl-nucleotide exchange factor activity GO:0017112 IDA
Biological Process
    positive regulation of GTPase activity GO:0043547 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
 Experiment description of studies that identified ST5 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ST5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ABL1 25
Reconstituted Complex Homo sapiens
2 SFN 2810
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ST5 is involved
No pathways found

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