Gene description for SNAPIN
Gene name SNAP-associated protein
Gene symbol SNAPIN
Other names/aliases BLOC1S7
BLOS7
SNAPAP
Species Homo sapiens
 Database cross references - SNAPIN
ExoCarta ExoCarta_23557
Vesiclepedia VP_23557
Entrez Gene 23557
HGNC 17145
MIM 607007
UniProt O95295  
 SNAPIN identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SNAPIN
Molecular Function
    SNARE binding GO:0000149 IBA
    SNARE binding GO:0000149 IDA
    protein binding GO:0005515 IPI
Biological Process
    intracellular protein transport GO:0006886 IEA
    lysosome organization GO:0007040 IBA
    lysosomal lumen acidification GO:0007042 IEA
    neurotransmitter secretion GO:0007269 TAS
    anterograde axonal transport GO:0008089 ISS
    retrograde axonal transport GO:0008090 IEA
    endosome to lysosome transport GO:0008333 IBA
    endosome to lysosome transport GO:0008333 IGI
    negative regulation of neuron projection development GO:0010977 IEA
    synaptic vesicle exocytosis GO:0016079 IBA
    synaptic vesicle exocytosis GO:0016079 IDA
    synaptic vesicle maturation GO:0016188 IEA
    neuron projection development GO:0031175 ISS
    protein-containing complex localization GO:0031503 IEA
    synaptic vesicle fusion to presynaptic active zone membrane GO:0031629 IEA
    lysosome localization GO:0032418 IBA
    lysosome localization GO:0032418 IMP
    lysosome localization GO:0032418 NAS
    melanosome organization GO:0032438 NAS
    regulation of protein binding GO:0043393 IMP
    synaptic vesicle transport GO:0048489 IBA
    synaptic vesicle transport GO:0048489 IMP
    anterograde synaptic vesicle transport GO:0048490 ISS
    regulation of endosome size GO:0051036 NAS
    protein maturation GO:0051604 IEA
    regulation of lysosome size GO:0062196 NAS
    neuron cellular homeostasis GO:0070050 IEA
    organelle transport along microtubule GO:0072384 NAS
    terminal button organization GO:0072553 IEA
    autophagosome maturation GO:0097352 IEA
    late endosome to lysosome transport GO:1902774 IEA
    positive regulation of late endosome to lysosome transport GO:1902824 TAS
    regulation of synaptic vesicle exocytosis GO:2000300 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    acrosomal vesicle GO:0001669 IEA
    manchette GO:0002177 IEA
    cytosol GO:0005829 IEA
    synaptic vesicle GO:0008021 IBA
    synaptic vesicle GO:0008021 IDA
    secretory granule GO:0030141 IBA
    secretory granule GO:0030141 ISS
    synaptic vesicle membrane GO:0030672 IEA
    BLOC-1 complex GO:0031083 IBA
    BLOC-1 complex GO:0031083 IDA
    BLOC-1 complex GO:0031083 IPI
    synapse GO:0045202 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    cytoplasmic side of lysosomal membrane GO:0098574 NAS
    BORC complex GO:0099078 IDA
    BORC complex GO:0099078 IPI
    axon cytoplasm GO:1904115 IEA
    microvesicle GO:1990742 IEA
 Experiment description of studies that identified SNAPIN in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SNAPIN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 C20orf202  
Two-hybrid Homo sapiens
2 CCDC151  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 NECAB2  
Two-hybrid Homo sapiens
4 TOR1A 1861
Affinity Capture-Western Homo sapiens
5 BLOC1S6  
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
6 EEF1G 1937
Two-hybrid Homo sapiens
7 SNAP23 8773
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
8 MARCKS 4082
Proximity Label-MS Homo sapiens
9 LAMP3  
Proximity Label-MS Homo sapiens
10 TEX35  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TPM2 7169
Two-hybrid Homo sapiens
12 CEP170 9859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 NUP62 23636
Affinity Capture-MS Homo sapiens
14 Ndc80  
Affinity Capture-MS Mus musculus
15 LAMP2 3920
Proximity Label-MS Homo sapiens
16 CCDC102B  
Two-hybrid Homo sapiens
17 TPM4 7171
Two-hybrid Homo sapiens
18 KAT7  
Two-hybrid Homo sapiens
19 LAMC1 3915
Two-hybrid Homo sapiens
20 BLOC1S1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
21 SKA1  
Two-hybrid Homo sapiens
22 EXOC1 55763
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 NME7 29922
Two-hybrid Homo sapiens
24 WHAMMP3  
Affinity Capture-MS Homo sapiens
25 Cep170  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
26 CCDC53 51019
Two-hybrid Homo sapiens
27 MAPK14 1432
Two-hybrid Homo sapiens
28 LAMTOR3 8649
Affinity Capture-MS Homo sapiens
29 BNIPL  
Two-hybrid Homo sapiens
30 HAP1  
Two-hybrid Homo sapiens
31 LAMTOR4 389541
Affinity Capture-MS Homo sapiens
32 FSD2 123722
Two-hybrid Homo sapiens
33 EXOC7 23265
Two-hybrid Homo sapiens
34 LAMTOR1 55004
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 C15orf59  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
36 RABGEF1 27342
Two-hybrid Homo sapiens
37 SPAG5 10615
Two-hybrid Homo sapiens
38 BANP  
Two-hybrid Homo sapiens
39 GPRASP1  
Two-hybrid Homo sapiens
40 LMNB1 4001
Two-hybrid Homo sapiens
41 TCP10L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 TRIML2  
Affinity Capture-MS Homo sapiens
43 IKBIP 121457
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
44 KLC1 3831
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 BLOC1S3 388552
Affinity Capture-Western Homo sapiens
46 DTNBP1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
47 DNAJC5 80331
Proximity Label-MS Homo sapiens
48 BLOC1S5 63915
Affinity Capture-MS Homo sapiens
49 ANGPT4  
Affinity Capture-MS Homo sapiens
50 SMAD2 4087
Two-hybrid Homo sapiens
51 RNF13 11342
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
52 SCOC 60592
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 MEF2BNB  
Affinity Capture-MS Homo sapiens
54 TMEM171  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 SYBU  
Affinity Capture-MS Homo sapiens
56 CNGA4  
Affinity Capture-MS Homo sapiens
57 S100P 6286
Affinity Capture-MS Homo sapiens
58 NUP62CL  
Two-hybrid Homo sapiens
59 EGLN3  
Affinity Capture-MS Homo sapiens
60 MTNR1A  
Two-hybrid Homo sapiens
61 BFSP2  
Two-hybrid Homo sapiens
62 CEBPG  
Affinity Capture-MS Homo sapiens
63 BCAS4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 KRT26 353288
Two-hybrid Homo sapiens
65 LAMTOR5 10542
Affinity Capture-MS Homo sapiens
66 KRT27 342574
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
67 KRT15 3866
Two-hybrid Homo sapiens
68 COG6 57511
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 TRPV1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
70 RAB9A 9367
Proximity Label-MS Homo sapiens
71 KAT5  
Two-hybrid Homo sapiens
72 KRT19 3880
Proximity Label-MS Homo sapiens
Two-hybrid Homo sapiens
73 ENTHD1  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
74 KRT16 3868
Two-hybrid Homo sapiens
75 TPM3 7170
Two-hybrid Homo sapiens
76 IMMT 10989
Two-hybrid Homo sapiens
77 IKBKAP 8518
Two-hybrid Homo sapiens
78 TRAK2 66008
Affinity Capture-MS Homo sapiens
79 RGS7  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
80 CEP170P1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 BLOC1S2 282991
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
82 SPP1 6696
Two-hybrid Homo sapiens
83 BFSP1  
Two-hybrid Homo sapiens
84 TSKS  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 DYRK3  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
86 PCYT1A 5130
Two-hybrid Homo sapiens
87 SNAP25 6616
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
88 KIF5C 3800
Two-hybrid Homo sapiens
89 BRK1 55845
Affinity Capture-MS Homo sapiens
90 DYNC1H1 1778
Affinity Capture-Western Homo sapiens
91 C10orf32  
Affinity Capture-MS Homo sapiens
92 KRT24 192666
Two-hybrid Homo sapiens
93 ABI2 10152
Two-hybrid Homo sapiens
94 RAB2A 5862
Proximity Label-MS Homo sapiens
95 KRT20 54474
Two-hybrid Homo sapiens
96 DDR1 780
Two-hybrid Homo sapiens
97 BLOC1S4 55330
Two-hybrid Homo sapiens
98 RAB7A 7879
Proximity Label-MS Homo sapiens
99 DENND1C  
Two-hybrid Homo sapiens
100 MYPOP  
Affinity Capture-MS Homo sapiens
101 KANK2 25959
Two-hybrid Homo sapiens
102 KXD1 79036
Affinity Capture-MS Homo sapiens
103 TRIM69 140691
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 SERBP1 26135
Affinity Capture-MS Homo sapiens
105 KRT23  
Affinity Capture-MS Homo sapiens
106 COPS4 51138
Affinity Capture-Western Homo sapiens
107 COG7 91949
Affinity Capture-MS Homo sapiens
108 PLAC9 219348
Two-hybrid Homo sapiens
109 C17orf59 54785
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here