Gene description for IFIT1
Gene name interferon-induced protein with tetratricopeptide repeats 1
Gene symbol IFIT1
Other names/aliases C56
Species Homo sapiens
 Database cross references - IFIT1
ExoCarta ExoCarta_3434
Entrez Gene 3434
HGNC 5407
MIM 147690
UniProt P09914  
 IFIT1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for IFIT1
Molecular Function
    RNA binding GO:0003723 IDA
    protein binding GO:0005515 IPI
Biological Process
    cellular response to type I interferon GO:0071357 IDA
    cellular response to exogenous dsRNA GO:0071360 IDA
    negative regulation of helicase activity GO:0051097 IDA
    negative regulation of protein binding GO:0032091 IDA
    response to virus GO:0009615 IMP
    negative regulation of viral genome replication GO:0045071 IMP
    positive regulation of viral genome replication GO:0045070 IDA
    cytokine-mediated signaling pathway GO:0019221 TAS
    defense response to virus GO:0051607 IEA
    negative regulation of defense response to virus by host GO:0050689 IDA
    intracellular transport of viral protein in host cell GO:0019060 IDA
    type I interferon signaling pathway GO:0060337 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    host cell GO:0043657 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified IFIT1 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IFIT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IFIT3 3437
Two-hybrid Homo sapiens
2 EIF3E 3646
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which IFIT1 is involved
Interferon alpha/beta signaling TAS Reactome
ISG15 antiviral mechanism TAS Reactome

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