Gene description for PTPRD
Gene name protein tyrosine phosphatase, receptor type, D
Gene symbol PTPRD
Other names/aliases HPTP
Species Homo sapiens
 Database cross references - PTPRD
ExoCarta ExoCarta_5789
Entrez Gene 5789
HGNC 9668
MIM 601598
UniProt P23468  
 PTPRD identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for PTPRD
Molecular Function
    cell adhesion molecule binding GO:0050839 ISS
    transmembrane receptor protein tyrosine phosphatase activity GO:0005001 TAS
    receptor binding GO:0005102 ISS
    protein binding GO:0005515 IPI
Biological Process
    peptidyl-tyrosine dephosphorylation GO:0035335 TAS
    presynaptic membrane assembly GO:0097105 ISS
    protein dephosphorylation GO:0006470 TAS
    neuron differentiation GO:0030182 ISS
    phosphate-containing compound metabolic process GO:0006796 NAS
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 ISS
    transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 TAS
    positive regulation of dendrite morphogenesis GO:0050775 ISS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    integral component of plasma membrane GO:0005887 TAS
 Experiment description of studies that identified PTPRD in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PTPRD
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPFIA1 8500
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
2 PPFIA2 8499
Invitro Homo sapiens
3 PTPRS 5802
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
4 PPFIA3 8541
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which PTPRD is involved
No pathways found

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