Gene description for PTPRD
Gene name protein tyrosine phosphatase, receptor type, D
Gene symbol PTPRD
Other names/aliases HPTP
HPTPD
HPTPDELTA
PTPD
RPTPDELTA
Species Homo sapiens
 Database cross references - PTPRD
ExoCarta ExoCarta_5789
Vesiclepedia VP_5789
Entrez Gene 5789
HGNC 9668
MIM 601598
UniProt P23468  
 PTPRD identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocytes 26054723    
 Gene ontology annotations for PTPRD
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 IBA
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    transmembrane receptor protein tyrosine phosphatase activity GO:0005001 TAS
    signaling receptor binding GO:0005102 ISS
    protein binding GO:0005515 IPI
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    cell adhesion molecule binding GO:0050839 ISS
    histone H2AXY142 phosphatase activity GO:0140793 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    phosphate-containing compound metabolic process GO:0006796 NAS
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IEA
    signal transduction GO:0007165 IBA
    cell surface receptor protein tyrosine phosphatase signaling pathway GO:0007185 TAS
    nervous system development GO:0007399 IBA
    neuron differentiation GO:0030182 ISS
    cellular response to platelet-derived growth factor stimulus GO:0036120 IEA
    negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 IEA
    regulation of immune response GO:0050776 IEA
    modulation of chemical synaptic transmission GO:0050804 IEA
    positive regulation of synapse assembly GO:0051965 ISS
    positive regulation of dendritic spine morphogenesis GO:0061003 ISS
    cellular response to hypoxia GO:0071456 IEA
    presynaptic membrane assembly GO:0097105 ISS
    presynapse assembly GO:0099054 IDA
    presynapse assembly GO:0099054 IMP
    regulation of postsynaptic density assembly GO:0099151 IEA
    trans-synaptic signaling by trans-synaptic complex GO:0099545 IDA
    trans-synaptic signaling by trans-synaptic complex GO:0099545 IMP
    synaptic membrane adhesion GO:0099560 IBA
    synaptic membrane adhesion GO:0099560 IDA
    synaptic membrane adhesion GO:0099560 IMP
    synaptic membrane adhesion GO:0099560 ISS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    presynaptic membrane GO:0042734 IEA
    extracellular exosome GO:0070062 HDA
    Schaffer collateral - CA1 synapse GO:0098685 IEA
    hippocampal mossy fiber to CA3 synapse GO:0098686 IEA
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
 Experiment description of studies that identified PTPRD in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PTPRD
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 COPG2 26958
Affinity Capture-MS Homo sapiens
3 SEZ6L  
Affinity Capture-MS Homo sapiens
4 PCDHGA6 56109
Affinity Capture-MS Homo sapiens
5 ICOSLG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TSSK2  
Reconstituted Complex Homo sapiens
7 MATK  
Reconstituted Complex Homo sapiens
8 LPAR6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 LRRN2 10446
Affinity Capture-MS Homo sapiens
10 PCDHGB4 8641
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 MARCH2  
Affinity Capture-MS Homo sapiens
12 HCRTR2  
Affinity Capture-MS Homo sapiens
13 LGALS1 3956
Affinity Capture-MS Homo sapiens
14 PLAC8L1  
Affinity Capture-MS Homo sapiens
15 MILR1  
Affinity Capture-MS Homo sapiens
16 FFAR1  
Affinity Capture-MS Homo sapiens
17 EPHA8  
Reconstituted Complex Homo sapiens
18 EGFR 1956
Affinity Capture-MS Homo sapiens
19 PIGN 23556
Affinity Capture-MS Homo sapiens
20 MARK2 2011
Reconstituted Complex Homo sapiens
21 ABLIM1 3983
Reconstituted Complex Homo sapiens
22 LINGO2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 ZDHHC11  
Affinity Capture-MS Homo sapiens
24 NIPAL1  
Affinity Capture-MS Homo sapiens
25 SLC31A1 1317
Affinity Capture-MS Homo sapiens
26 PMEL 6490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 RNF133  
Affinity Capture-MS Homo sapiens
28 TMEM150A  
Affinity Capture-MS Homo sapiens
29 TMEM132D  
Two-hybrid Homo sapiens
30 C19orf45  
Affinity Capture-MS Homo sapiens
31 CLDND1 56650
Affinity Capture-MS Homo sapiens
32 LAMTOR1 55004
Affinity Capture-MS Homo sapiens
33 DSC3 1825
Proximity Label-MS Homo sapiens
34 MTNR1B  
Two-hybrid Homo sapiens
35 IL32  
Affinity Capture-MS Homo sapiens
36 AURKA 6790
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
37 UGT1A1  
Affinity Capture-MS Homo sapiens
38 KCNC3 3748
Affinity Capture-MS Homo sapiens
39 TBK1 29110
Reconstituted Complex Homo sapiens
40 SCEL 8796
Reconstituted Complex Homo sapiens
41 PCDHB6  
Affinity Capture-MS Homo sapiens
42 AVPR1B  
Affinity Capture-MS Homo sapiens
43 STMN4  
Affinity Capture-MS Homo sapiens
44 PRRT3 285368
Affinity Capture-MS Homo sapiens
45 TIGIT  
Affinity Capture-MS Homo sapiens
46 SMTNL2  
Reconstituted Complex Homo sapiens
47 FYN 2534
Affinity Capture-MS Homo sapiens
48 IL17RD  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 IL20RA  
Affinity Capture-MS Homo sapiens
50 DDX54 79039
Reconstituted Complex Homo sapiens
51 TPP2 7174
Affinity Capture-MS Homo sapiens
52 DDX17 10521
Reconstituted Complex Homo sapiens
53 BMX  
Reconstituted Complex Homo sapiens
54 ARHGAP36  
Affinity Capture-MS Homo sapiens
55 TNFRSF10A 8797
Affinity Capture-MS Homo sapiens
56 TMEM52B 120939
Affinity Capture-MS Homo sapiens
57 MCOLN2  
Affinity Capture-MS Homo sapiens
58 GPC4 2239
Reconstituted Complex Homo sapiens
59 LRRN1 57633
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 HADHB 3032
Affinity Capture-MS Homo sapiens
61 HADHA 3030
Affinity Capture-MS Homo sapiens
62 PCDH20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 FURIN 5045
Affinity Capture-MS Homo sapiens
64 KIR2DL1  
Affinity Capture-MS Homo sapiens
65 PCDHB1  
Affinity Capture-MS Homo sapiens
66 CD83  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 LILRB4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 KCNK18  
Affinity Capture-MS Homo sapiens
69 TMEM223  
Affinity Capture-MS Homo sapiens
70 TRIO 7204
Proximity Label-MS Homo sapiens
71 MTNR1A  
Two-hybrid Homo sapiens
72 SLCO4C1 353189
Affinity Capture-MS Homo sapiens
73 PLK1 5347
Reconstituted Complex Homo sapiens
74 TBXA2R 6915
Affinity Capture-MS Homo sapiens
75 SLAIN2  
Reconstituted Complex Homo sapiens
76 CSNK1D 1453
Reconstituted Complex Homo sapiens
77 RELT  
Affinity Capture-MS Homo sapiens
78 POTEA  
Affinity Capture-MS Homo sapiens
79 PEBP1 5037
Co-fractionation Homo sapiens
80 OMG  
Reconstituted Complex Homo sapiens
81 TGFA  
Affinity Capture-MS Homo sapiens
82 SCN2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 TPCN2  
Affinity Capture-MS Homo sapiens
84 CSNK1E 1454
Reconstituted Complex Homo sapiens
85 GPR37  
Affinity Capture-MS Homo sapiens
86 PPFIA1 8500
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
87 LRRTM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 TGFBR2 7048
Affinity Capture-MS Homo sapiens
89 OPALIN  
Affinity Capture-MS Homo sapiens
90 NLGN3  
Affinity Capture-MS Homo sapiens
91 IL2RG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 NEK6 10783
Reconstituted Complex Homo sapiens
93 RYK 6259
Affinity Capture-MS Homo sapiens
94 LITAF 9516
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 ANKRD26P1  
Affinity Capture-MS Homo sapiens
96 MRAP2  
Affinity Capture-MS Homo sapiens
97 IL3RA  
Affinity Capture-MS Homo sapiens
98 NEK1  
Reconstituted Complex Homo sapiens
99 IZUMO1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 NEK2  
Reconstituted Complex Homo sapiens
101 PTPRS 5802
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
102 RPL28 6158
Affinity Capture-MS Homo sapiens
103 PCDHB16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 ABCG8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 PIANP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 IRS1 3667
Reconstituted Complex Homo sapiens
107 PAK6 56924
Reconstituted Complex Homo sapiens
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