Gene description for SHROOM3
Gene name shroom family member 3
Gene symbol SHROOM3
Other names/aliases APXL3
Species Homo sapiens
 Database cross references - SHROOM3
ExoCarta ExoCarta_57619
Entrez Gene 57619
HGNC 30422
MIM 604570
UniProt Q8TF72  
 SHROOM3 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SHROOM3
Molecular Function
    actin filament binding GO:0051015 IEA
Biological Process
    regulation of cell shape GO:0008360 IEA
    neural tube closure GO:0001843 IEA
    cellular pigment accumulation GO:0043482 ISS
    pattern specification process GO:0007389 ISS
    actin cytoskeleton organization GO:0030036 IEA
    columnar/cuboidal epithelial cell development GO:0002066 IEA
    cell morphogenesis GO:0000902 ISS
    apical protein localization GO:0045176 ISS
Subcellular Localization
    apical plasma membrane GO:0016324 ISS
    cytoplasm GO:0005737 IEA
    microtubule GO:0005874 IEA
    apical junction complex GO:0043296 ISS
    cytoskeleton GO:0005856 ISS
    adherens junction GO:0005912 ISS
 Experiment description of studies that identified SHROOM3 in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SHROOM3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SFN 2810
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SHROOM3 is involved
No pathways found

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