Gene description for STRN4
Gene name striatin, calmodulin binding protein 4
Gene symbol STRN4
Other names/aliases ZIN
zinedin
Species Homo sapiens
 Database cross references - STRN4
ExoCarta ExoCarta_29888
Entrez Gene 29888
HGNC 15721
MIM 614767
UniProt Q9NRL3  
 STRN4 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for STRN4
Molecular Function
    protein phosphatase 2A binding GO:0051721 IDA
    protein binding GO:0005515 IPI
    protein complex binding GO:0032403 IDA
    armadillo repeat domain binding GO:0070016 IPI
    calmodulin binding GO:0005516 NAS
Biological Process
    biological_process GO:0008150 ND
Subcellular Localization
    dendritic spine GO:0043197 IEA
    membrane GO:0016020 IEA
    cytoplasm GO:0005737 IEA
    protein phosphatase type 2A complex GO:0000159 IDA
 Experiment description of studies that identified STRN4 in exosomes
1
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for STRN4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STRIP1 85369
Affinity Capture-MS Homo sapiens
2 STK24 8428
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 STK25 10494
Affinity Capture-MS Homo sapiens
4 SLC25A6 293
Two-hybrid Homo sapiens
5 AK5  
Two-hybrid Homo sapiens
6 FLJ21168  
Affinity Capture-MS Homo sapiens
7 NBEA  
Two-hybrid Homo sapiens
8 ASNS 440
Two-hybrid Homo sapiens
9 T3JAM  
Affinity Capture-MS Homo sapiens
10 CLDN12 9069
Two-hybrid Homo sapiens
11 GDF9 2661
Two-hybrid Homo sapiens
12 GTP  
Two-hybrid Homo sapiens
13 STRN3 29966
Affinity Capture-MS Homo sapiens
14 MCC 4163
Affinity Capture-MS Homo sapiens
15 STRN  
Affinity Capture-MS Homo sapiens
16 KLHDC2  
Two-hybrid Homo sapiens
17 STK26 51765
Affinity Capture-MS Homo sapiens
18 PREI3  
Affinity Capture-MS Homo sapiens
19 PI4KA 5297
Two-hybrid Homo sapiens
20 PDCD10 11235
Affinity Capture-MS Homo sapiens
21 BAT1  
Two-hybrid Homo sapiens
22 DKFZp547A023  
Affinity Capture-MS Homo sapiens
23 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
24 PPP2CA 5515
Affinity Capture-MS Homo sapiens
25 PPP2CB 5516
Affinity Capture-MS Homo sapiens
26 CTTNBP2  
Affinity Capture-MS Homo sapiens
27 ECSIT 51295
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which STRN4 is involved
No pathways found





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