Gene description for DNAH1
Gene name dynein, axonemal, heavy chain 1
Gene symbol DNAH1
Other names/aliases DNAHC1
HDHC7
HL-11
HL11
HSRF-1
XLHSRF-1
Species Homo sapiens
 Database cross references - DNAH1
ExoCarta ExoCarta_25981
Entrez Gene 25981
HGNC 2940
MIM 603332
UniProt Q9P2D7  
 DNAH1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for DNAH1
Molecular Function
    microtubule motor activity GO:0003777 NAS
    ATP binding GO:0005524 IEA
    ATPase activity GO:0016887 IEA
Biological Process
    cilium movement GO:0003341 IEA
    response to mechanical stimulus GO:0009612 NAS
    cilium or flagellum-dependent cell motility GO:0001539 NAS
    metabolic process GO:0008152 NAS
Subcellular Localization
    dynein complex GO:0030286 NAS
    axonemal dynein complex GO:0005858 NAS
    microtubule GO:0005874 IEA
    sperm flagellum GO:0036126 IDA
 Experiment description of studies that identified DNAH1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for DNAH1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DNAH1 is involved
No pathways found





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