Gene description for JPH2
Gene name junctophilin 2
Gene symbol JPH2
Other names/aliases CMH17
JP-2
JP2
Species Homo sapiens
 Database cross references - JPH2
ExoCarta ExoCarta_57158
Vesiclepedia VP_57158
Entrez Gene 57158
HGNC 14202
MIM 605267
UniProt Q9BR39  
 JPH2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for JPH2
Molecular Function
    core promoter sequence-specific DNA binding GO:0001046 ISS
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 ISS
    phosphatidylserine binding GO:0001786 IDA
    DNA binding GO:0003677 IEA
    protein binding GO:0005515 IPI
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IDA
    phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 IDA
    phosphatidylinositol-5-phosphate binding GO:0010314 IDA
    phosphatidylinositol-3-phosphate binding GO:0032266 IDA
    phosphatidylinositol-4-phosphate binding GO:0070273 IDA
    phosphatidic acid binding GO:0070300 IDA
    phosphatidylinositol-3,5-bisphosphate binding GO:0080025 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    negative regulation of DNA-templated transcription GO:0045892 ISS
    regulation of cardiac muscle tissue development GO:0055024 IEA
    calcium ion homeostasis GO:0055074 IDA
    regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 TAS
    positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 IDA
    calcium ion transport into cytosol GO:0060402 TAS
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IEA
    endoplasmic reticulum membrane GO:0005789 IBA
    plasma membrane GO:0005886 IBA
    junctional sarcoplasmic reticulum membrane GO:0014701 TAS
    sarcoplasmic reticulum GO:0016529 IBA
    Z disc GO:0030018 IEA
    junctional membrane complex GO:0030314 IBA
 Experiment description of studies that identified JPH2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for JPH2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CAV3 859
Affinity Capture-Western Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 HIST1H2BH 8345
Cross-Linking-MS (XL-MS) Homo sapiens
4 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
5 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
6 HIST1H2AG 8969
Cross-Linking-MS (XL-MS) Homo sapiens
7 SOX2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which JPH2 is involved
No pathways found





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