Gene description for INTS3
Gene name integrator complex subunit 3
Gene symbol INTS3
Other names/aliases C1orf193
C1orf60
INT3
SOSS-A
SOSSA
Species Homo sapiens
 Database cross references - INTS3
ExoCarta ExoCarta_65123
Vesiclepedia VP_65123
Entrez Gene 65123
HGNC 26153
MIM 611347
UniProt Q68E01  
 INTS3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
 Gene ontology annotations for INTS3
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    double-strand break repair via homologous recombination GO:0000724 IDA
    DNA repair GO:0006281 IMP
    DNA damage response GO:0006974 IMP
    response to ionizing radiation GO:0010212 IMP
    snRNA processing GO:0016180 IDA
    snRNA processing GO:0016180 NAS
    regulation of transcription elongation by RNA polymerase II GO:0034243 NAS
    mitotic G2/M transition checkpoint GO:0044818 IDA
    mitotic G2/M transition checkpoint GO:0044818 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    integrator complex GO:0032039 IDA
    integrator complex GO:0032039 NAS
    site of double-strand break GO:0035861 IDA
    SOSS complex GO:0070876 IDA
    SOSS complex GO:0070876 IPI
 Experiment description of studies that identified INTS3 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for INTS3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 INTS4  
Affinity Capture-MS Homo sapiens
2 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
3 VWA9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 POLR2G 5436
Affinity Capture-MS Homo sapiens
5 KLK15  
Affinity Capture-MS Homo sapiens
6 ZMYND8 23613
Affinity Capture-MS Homo sapiens
7 LPAR6  
Affinity Capture-MS Homo sapiens
8 RPA2 6118
Affinity Capture-MS Homo sapiens
9 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
10 INTS10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 DDX26B  
Affinity Capture-MS Homo sapiens
12 NAIF1  
Affinity Capture-MS Homo sapiens
13 NABP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
14 INTS1 26173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
15 GLCE 26035
Affinity Capture-MS Homo sapiens
16 PNKD  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 APP 351
Reconstituted Complex Homo sapiens
18 DNAJB6 10049
Affinity Capture-MS Homo sapiens
19 INTS9 55756
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 KIAA1429 25962
Affinity Capture-MS Homo sapiens
21 INTS8  
Affinity Capture-MS Homo sapiens
22 WDR76  
Affinity Capture-MS Homo sapiens
23 INIP  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
24 COPB2 9276
Co-fractionation Homo sapiens
25 POLR2I 5438
Affinity Capture-MS Homo sapiens
26 INTS12  
Affinity Capture-MS Homo sapiens
27 HMGA1 3159
Affinity Capture-MS Homo sapiens
28 TACSTD2 4070
Affinity Capture-MS Homo sapiens
29 BRD4 23476
Affinity Capture-MS Homo sapiens
30 INTS6 26512
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 ZBTB14  
Two-hybrid Homo sapiens
32 POLR2C 5432
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 TEX13B  
Affinity Capture-MS Homo sapiens
34 FAF2 23197
Affinity Capture-MS Homo sapiens
35 GPR17 2840
Affinity Capture-MS Homo sapiens
36 NABP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
37 POLR2K  
Affinity Capture-MS Homo sapiens
38 CD70 970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 CPNE2 221184
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
41 C7orf26  
Affinity Capture-MS Homo sapiens
42 CTDP1 9150
Reconstituted Complex Homo sapiens
43 SUPT5H 6829
Affinity Capture-MS Homo sapiens
44 HSP90B1 7184
Co-fractionation Homo sapiens
45 COMTD1 118881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 ST6GAL1 6480
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 NTRK1 4914
Affinity Capture-MS Homo sapiens
48 INTS7  
Affinity Capture-MS Homo sapiens
49 TEAD2  
Affinity Capture-MS Homo sapiens
50 PPP2CA 5515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 ASUN  
Affinity Capture-MS Homo sapiens
52 EED  
Affinity Capture-MS Homo sapiens
53 UBXN6 80700
Affinity Capture-MS Homo sapiens
54 POLR2B 5431
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
55 CDS2 8760
Affinity Capture-MS Homo sapiens
56 NUMA1 4926
Affinity Capture-MS Homo sapiens
57 SIGLECL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 POLR2H 5437
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 BTNL9  
Affinity Capture-MS Homo sapiens
60 POLR2E 5434
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 CUL3 8452
Affinity Capture-MS Homo sapiens
62 NR3C1 2908
Proximity Label-MS Homo sapiens
63 POLR2D  
Affinity Capture-MS Homo sapiens
64 FOXL1  
Affinity Capture-MS Homo sapiens
65 METTL21B  
Affinity Capture-MS Homo sapiens
66 POLR2A 5430
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
67 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
68 OCIAD1 54940
Affinity Capture-MS Homo sapiens
69 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 RPA3 6119
Affinity Capture-MS Homo sapiens
71 LSM3 27258
Affinity Capture-MS Homo sapiens
72 NPAS1  
Affinity Capture-MS Homo sapiens
73 GPR45  
Affinity Capture-MS Homo sapiens
74 TOP1 7150
Affinity Capture-MS Homo sapiens
75 ZNF687  
Affinity Capture-MS Homo sapiens
76 SNW1 22938
Affinity Capture-MS Homo sapiens
77 ZNF592 9640
Affinity Capture-MS Homo sapiens
78 CPSF3L 54973
Affinity Capture-MS Homo sapiens
79 INTS5 80789
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 PPP2CB 5516
Affinity Capture-MS Homo sapiens
81 PPP2R1B 5519
Affinity Capture-MS Homo sapiens
82 GYPA  
Affinity Capture-MS Homo sapiens
83 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
84 ALDH3A2 224
Affinity Capture-MS Homo sapiens
85 POLR2F  
Affinity Capture-MS Homo sapiens
86 PRKY  
Affinity Capture-MS Homo sapiens
87 POLR2J  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 HMGB1 3146
Co-fractionation Homo sapiens
89 MFSD4  
Affinity Capture-MS Homo sapiens
90 SSRP1 6749
Affinity Capture-MS Homo sapiens
91 RPA1 6117
Affinity Capture-MS Homo sapiens
92 RP2 6102
Affinity Capture-MS Homo sapiens
93 HMGN5 79366
Affinity Capture-MS Homo sapiens
94 CAPZA2 830
Affinity Capture-MS Homo sapiens
95 RPAP2  
Affinity Capture-MS Homo sapiens
96 INTS2  
Affinity Capture-MS Homo sapiens
97 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
98 SSBP1 6742
Affinity Capture-Western Homo sapiens
99 ADORA3  
Affinity Capture-MS Homo sapiens
100 TPST2 8459
Affinity Capture-MS Homo sapiens
101 KIR2DL4  
Affinity Capture-MS Homo sapiens
102 KRAS 3845
Synthetic Lethality Homo sapiens
Negative Genetic Homo sapiens
103 NUCKS1 64710
Affinity Capture-MS Homo sapiens
104 DNAI2  
Affinity Capture-MS Homo sapiens
105 Smn1 20595
Affinity Capture-MS Mus musculus
106 CDC5L 988
Affinity Capture-MS Homo sapiens
107 S1PR4  
Affinity Capture-MS Homo sapiens
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